首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   82134篇
  免费   7375篇
  国内免费   5483篇
耳鼻咽喉   845篇
儿科学   884篇
妇产科学   1224篇
基础医学   10591篇
口腔科学   1401篇
临床医学   10927篇
内科学   12343篇
皮肤病学   1027篇
神经病学   4504篇
特种医学   3092篇
外国民族医学   53篇
外科学   8550篇
综合类   10853篇
现状与发展   21篇
一般理论   22篇
预防医学   5135篇
眼科学   2987篇
药学   8561篇
  68篇
中国医学   4183篇
肿瘤学   7721篇
  2024年   261篇
  2023年   1225篇
  2022年   3196篇
  2021年   4114篇
  2020年   3021篇
  2019年   2894篇
  2018年   3087篇
  2017年   2553篇
  2016年   2657篇
  2015年   3821篇
  2014年   4743篇
  2013年   4182篇
  2012年   6195篇
  2011年   6635篇
  2010年   4090篇
  2009年   3095篇
  2008年   4290篇
  2007年   4161篇
  2006年   4261篇
  2005年   4099篇
  2004年   2777篇
  2003年   2545篇
  2002年   2087篇
  2001年   1793篇
  2000年   1773篇
  1999年   2060篇
  1998年   1299篇
  1997年   1268篇
  1996年   958篇
  1995年   907篇
  1994年   765篇
  1993年   484篇
  1992年   593篇
  1991年   497篇
  1990年   471篇
  1989年   411篇
  1988年   371篇
  1987年   300篇
  1986年   248篇
  1985年   210篇
  1984年   130篇
  1983年   86篇
  1982年   42篇
  1981年   51篇
  1980年   29篇
  1979年   63篇
  1978年   22篇
  1974年   27篇
  1973年   18篇
  1968年   16篇
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
1.
2.
3.
4.
5.
6.
7.
1. To investigate Genkwa Flos hepatotoxicity, a cell metabolomics strategy combined with serum pharmacology was performed on human HL-7702 liver cells in this study.

2. Firstly, cell viability and biochemical indicators were determined and the cell morphology was observed to confirm the cell injury and develop a cell hepatotoxicity model. Then, with the help of cell metabolomics based on UPLC-MS, the Genkwa Flos group samples were completely separated from the blank group samples in the score plots and seven upregulated as well as two down-regulated putative biomarkers in the loading plot were identified and confirmed. Besides, two signal molecules and four enzymes involved in biosynthesis pathway of lysophosphatidylcholine and the sphingosine kinase/sphingosine-1-phosphate pathway were determined to investigate the relationship between Genkwa Flos hepatotoxicity and these two classic pathways. Finally, the metabolic pathways related to specific biomarkers and two classic metabolic pathways were analyzed to explain the possible mechanism of Genkwa Flos hepatotoxicity.

3. Based on the results, lipid peroxidation and oxidative stress, phospholipase A2/lysophosphatidylcholine pathway, the disturbance of sphingosine-1-phosphate metabolic profile centered on sphingosine kinase/sphingosine-1-phosphate pathway and fatty acid metabolism might be critical participators in the progression of liver injury induced by Genkwa Flos.  相似文献   

8.
9.
The associations between saturated fatty acid (SFA) consumption and risk of breast cancer (BC) remains inconclusive. Therefore, we conducted this meta-analysis to determine the quantitative relations between dietary SFA intake and incidence of BC.Literatures published up to April 2015 were systematically screened through Pubmed and Web of Science. Relevant publication quality was evaluated by conducting the Newcastle-Ottawa scale. We used fixed effects models or random effect models to calculate the summary relative risks (RRs) and odds ratios (ORs), and conducted sensitivity analyses and evaluated the publication bias.We identified a total of 52 studies (24 cohort studies and 28 case–control studies), with over 50,000 females diagnosed with BC. The associations between dietary SFA intake and risk of BC were 1.18 for case–control studies (high vs low intake, 95% confidence interval [CI] = 1.03–1.34) and 1.04 for cohort studies (95% CI = 0.97–1.11). When restricted analyses to population-based studies, positive associations were observed for both cohort (RR [95% CI] = 1.11 [1.01–1.21]) and case–control studies (OR [95% CI] = 1.26 [1.03–1.53]). Additionally, for case–control studies, significant positive associations between higher SFA intake and BC risk were observed for Asian (OR [95% CI] = 1.17 [1.02–1.34]) and Caucasian (OR [95% CI] = 1.19 [1.00–1.41]), as well as for postmenopausal women (OR = 1.33, 95% CI: 1.02–1.73). In contrast, higher dietary SFA intake was not associated with risk of BC among premenopausal women, in cohort studies or hospital-based studies.A positive association between higher dietary SFA intake and postmenopausal BC risk was observed in case–control but not in cohort studies. More studies are warranted to confirm these findings.  相似文献   
10.
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号