全文获取类型
收费全文 | 2391篇 |
免费 | 128篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 25篇 |
儿科学 | 35篇 |
妇产科学 | 36篇 |
基础医学 | 348篇 |
口腔科学 | 53篇 |
临床医学 | 151篇 |
内科学 | 547篇 |
皮肤病学 | 30篇 |
神经病学 | 204篇 |
特种医学 | 100篇 |
外科学 | 426篇 |
综合类 | 11篇 |
预防医学 | 39篇 |
眼科学 | 12篇 |
药学 | 227篇 |
中国医学 | 1篇 |
肿瘤学 | 278篇 |
出版年
2023年 | 26篇 |
2022年 | 17篇 |
2021年 | 57篇 |
2020年 | 25篇 |
2019年 | 36篇 |
2018年 | 59篇 |
2017年 | 38篇 |
2016年 | 50篇 |
2015年 | 60篇 |
2014年 | 56篇 |
2013年 | 67篇 |
2012年 | 101篇 |
2011年 | 129篇 |
2010年 | 64篇 |
2009年 | 49篇 |
2008年 | 82篇 |
2007年 | 92篇 |
2006年 | 105篇 |
2005年 | 78篇 |
2004年 | 74篇 |
2003年 | 96篇 |
2002年 | 100篇 |
2001年 | 102篇 |
2000年 | 104篇 |
1999年 | 91篇 |
1998年 | 15篇 |
1997年 | 33篇 |
1996年 | 20篇 |
1995年 | 20篇 |
1994年 | 14篇 |
1993年 | 26篇 |
1992年 | 84篇 |
1991年 | 63篇 |
1990年 | 49篇 |
1989年 | 59篇 |
1988年 | 34篇 |
1987年 | 47篇 |
1986年 | 51篇 |
1985年 | 47篇 |
1984年 | 27篇 |
1983年 | 24篇 |
1982年 | 13篇 |
1981年 | 8篇 |
1979年 | 28篇 |
1978年 | 15篇 |
1977年 | 8篇 |
1973年 | 8篇 |
1969年 | 7篇 |
1968年 | 9篇 |
1967年 | 7篇 |
排序方式: 共有2523条查询结果,搜索用时 31 毫秒
1.
2.
Mana Kogure Naho Tsuchiya Akira Narita Takumi Hirata Naoki Nakaya Tomohiro Nakamura Atsushi Hozawa Takehito Hayakawa Nagako Okuda Naoko Miyagawa Aya Kadota Takayoshi Ohkubo Yoshitaka Murakami Kiyomi Sakata Katsuyuki Miura Akira Okayama Tomonori Okamura Hirotsugu Ueshima 《Journal of epidemiology / Japan Epidemiological Association》2021,31(2):119
BackgroundMajor reasons for long-term care insurance certification in Japan are stroke, dementia, and fracture. These diseases are reported to be associated with calcium intake. This study examined the association between calcium intake and impaired activities of daily living (ADL) using the data from NIPPON DATA90, consisting of representative sample of the Japanese population.MethodsA population-based nested case-control study was performed. A baseline survey was conducted in 1990, followed by ADL surveys of individuals ≥65 years old in 2000. Individuals with impaired ADL and selected age- and sex-matched controls were then identified. We obtained 132 pairs. Calcium intake was energy-adjusted using the residual method. The association between calcium intake and impaired ADL was examined using conditional logistic regression models. To assess the accuracy of the estimates, we conducted bootstrap analyses.ResultsThe adjusted odds ratios (ORs) for impaired ADL compared with the group with a calcium intake of <476 mg/day were 0.72 (95% confidence interval [CI], 0.37–1.40) for the 476–606 mg/day group and 0.44 (95% CI, 0.21–0.94) for the ≥607 mg/day group in 2000 (P for linear trend = 0.03). After the bootstrap analyses, the inverse relationship unchanged (median OR per 100-mg rise in calcium intake, 0.87 [1,000 resamplings]; 95% CI, 0.76–0.97).ConclusionsAfter bootstrap analyses, calcium intake was inversely associated with impaired ADL 10 years after the baseline survey.Key words: bootstrap analyses, calcium intake, impaired activities of daily living, nested case-control study, NIPPON DATA90 相似文献
3.
4.
5.
Hiroyuki Takamatsu Takeshi Yamashita Shingo Kurahashi Takayuki Saitoh Tadakazu Kondo Takeshi Maeda Hideyuki Nakazawa Makoto Murata Tomoko Narita Junya Kuroda Hisako Hashimoto Koji Kawamura Toshihiro Miyamoto Sumihisa Honda Tatsuo Ichinohe Yoshiko Atsuta Kazutaka Sunami 《Biology of blood and marrow transplantation》2019,25(3):474-479
Conventional cytogenetic analyses and fluorescent in situ hybridization (FISH) are helpful for stratifying patients with multiple myeloma (MM) into high-risk [t(4;14), t(14;16), and/or del 17p] and standard-risk [t(11;14)] categories. However, the prognosis of patients with MM treated with autologous stem cell transplantation (ASCT) stratified according to these categories remains unclear. This retrospective observational study analyzed 97 patients with MM who received a single, planned ASCT after treatment with 200 mg/m2 melphalan between 2001 and 2011. The patients were grouped according to chromosomal abnormality, including t(11;14) (n?=?45), t(4;14) (n?=?31), del 17p (n?=?10), t(11;14) with del 17p (n?=?7), and t(4;14) with del 17p (n?=?4). Median overall survival (OS) of the t(11;14) group (64.1 months) was not significantly different from that of the t(4;14) group (not reached), but it was significantly longer than that of the del 17p group (23.0 months; P?=?.002). G-banding revealed that the median OS of the t(11;14) group with additional chromosomal abnormalities (ACAs) (46.2 months) was significantly shorter than that of the t(11;14) group without ACAs (not reached; P?=?.005) and the t(4;14) group (not reached; P?=?.010). These findings highlight the importance of G-banding in patients with t(11;14) MM. 相似文献
6.
This study was conducted to determine the fluoride intakes in 94 preschool children aged 3, 4 and 5 (n = 30, 30, 34, respectively) residing in Yokkaichi, Mie Prefecture (< 0.16 ppm F water supply). The parents duplicated all the diets that their children ingested on 3 separate days during a 1-year period. The acid-diffusible fluoride in the diet was isolated by the acid-diffusion technique and measured with a fluoride electrode. The mean daily fluoride intakes from diet alone by children aged 3, 4 and 5 were 0.30 mg (n = 29, SD 0.19), 0.28 mg (n = 30, SD 0.19) and 0.30 mg (n = 34, SD 0.19), respectively. The total estimated mean values from diet and dentifrice were 0.35 mg (n = 29, SD 0.22, range 0.13-1.00), 0.33 mg (n = 30, SD 0.19, range 0.13-0.86) and 0.39 mg (n = 34, SD 0.18, range 0.18-1.01), respectively. It was concluded that the mean (+/-SD) total fluoride from diet and dentifrice in 3- to 5-year-old Japanese children was 0.35 +/- 0.19 mg/day (0.021 +/- 0.012 mg/kg body weight). 相似文献
7.
8.
9.
The existence of familial aggregation of mandibular prognathism (MP) suggests that genetic components play an important role in its etiology. In this study, a genome-wide linkage analysis to identify loci susceptible to MP was conducted with 90 affected sibling-pairs in 42 families, comprised of 40 Korean sibling-pairs and 50 Japanese sibling-pairs. Two non-parametric linkage analyses, GENEHUNTER-PLUS and SIBPAL, were applied and detected nominal statistical significance of linkage to MP at chromosomes 1p36, 6q25, and 19p13.2. The best evidence of linkage was detected near D1S234 (maximum Z(lr) = 2.51, P = 0.0012). In addition, evidence of linkage was observed near D6S305 (maximum Z(lr) = 2.23, P = 0.025) and D19S884 (maximum Z(lr) = 1.93, P = 0.0089). Identification of the susceptible genes in the linkage regions will pave the way for insights into the molecular pathways that cause MP, especially overgrowth of the mandible, and may lead to the development of novel therapeutic tools. 相似文献
10.
Akira Yamashita Asami Hamada Yuki Suhara Rui Kawabe Makoto Yanase Naoko Kuzumaki Michiko Narita Ryosuke Matsui Hideyuki Okano Minoru Narita 《Synapse (New York, N.Y.)》2014,68(6):235-247
Insomnia, depression, and anxiety disorder are common problems for people with neuropathic pain. In this study, mild noxious heat stimuli increased the duration and number of spontaneous pain‐like behaviors in sciatic nerve‐ligated mice. We used functional magnetic resonance imaging to visualize the increased blood oxygenation level‐dependent signal intensity in the anterior cingulate cortex (ACC) of mice with sciatic nerve ligation under mild noxious stimuli. Such stimuli significantly increased the release of glutamate in the ACC of nerve‐ligated mice. In addition, sciatic nerve ligation and mild noxious stimuli changed the morphology of astrocytes in the ACC. Treatment of cortical astrocytes with glutamate caused astrocytic activation, as detected by a stellate morphology. Furthermore, glutamate induced the translocation of GAT‐3 to astrocyte cell membranes using primary cultured glial cells from the mouse cortex. Moreover, the GABA level at the synaptic cleft in the ACC of nerve‐ligated mice was significantly decreased exposure to mild noxious stimuli. Finally, we investigated whether astrocytic activation in the ACC could directly mediate sleep disorder. With the optogenetic tool channel rhodopsin‐2 (ChR2), we demonstrated that selective photostimulation of these astrocytes in vivo triggered sleep disturbance. Taken together, these results suggest that neuropathic pain‐like stimuli activated astrocytes in the ACC and decreased the extracellular concentration of GABA via an increase in the release of glutamate. Furthermore, these findings provide novel evidence that astrocytic activation in the ACC can mimic sleep disturbance in mice. Synapse 68:235–247, 2014 . © 2014 Wiley Periodicals, Inc. 相似文献