全文获取类型
收费全文 | 1190篇 |
免费 | 63篇 |
国内免费 | 56篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 69篇 |
妇产科学 | 12篇 |
基础医学 | 148篇 |
口腔科学 | 21篇 |
临床医学 | 149篇 |
内科学 | 265篇 |
皮肤病学 | 51篇 |
神经病学 | 64篇 |
特种医学 | 299篇 |
外科学 | 46篇 |
综合类 | 23篇 |
预防医学 | 39篇 |
眼科学 | 5篇 |
药学 | 58篇 |
中国医学 | 3篇 |
肿瘤学 | 55篇 |
出版年
2023年 | 4篇 |
2021年 | 9篇 |
2020年 | 9篇 |
2019年 | 12篇 |
2018年 | 18篇 |
2017年 | 5篇 |
2016年 | 8篇 |
2015年 | 14篇 |
2014年 | 16篇 |
2013年 | 41篇 |
2012年 | 31篇 |
2011年 | 19篇 |
2010年 | 39篇 |
2009年 | 62篇 |
2008年 | 23篇 |
2007年 | 55篇 |
2006年 | 23篇 |
2005年 | 24篇 |
2004年 | 12篇 |
2003年 | 12篇 |
2002年 | 14篇 |
2001年 | 13篇 |
2000年 | 19篇 |
1999年 | 19篇 |
1998年 | 71篇 |
1997年 | 81篇 |
1996年 | 103篇 |
1995年 | 63篇 |
1994年 | 60篇 |
1993年 | 53篇 |
1992年 | 18篇 |
1991年 | 18篇 |
1990年 | 21篇 |
1989年 | 37篇 |
1988年 | 38篇 |
1987年 | 35篇 |
1986年 | 48篇 |
1985年 | 40篇 |
1984年 | 11篇 |
1983年 | 14篇 |
1982年 | 13篇 |
1981年 | 10篇 |
1980年 | 11篇 |
1979年 | 8篇 |
1978年 | 13篇 |
1977年 | 10篇 |
1976年 | 13篇 |
1975年 | 13篇 |
1974年 | 2篇 |
1973年 | 2篇 |
排序方式: 共有1309条查询结果,搜索用时 31 毫秒
1.
2.
Raphaëlle Jouin Denis Chateaux Dominique Drapier Thierry Pham Hoang 《Annales médico-psychologiques》2019,177(9):902-910
Klinefelter syndrome (KS) (47,XXY) is the most common aneuploidy (1/650) of sexual chromosome among male (0,1 à 0,2 % of male population) (Hong and Reiss, 2014). Because its large physical phenotypic variability (high tall, sparse hairiness, gynecomastia), this syndrome is largely underdiagnosed (less than 25 % of affected persons) (Samango-Sprouse et al., 2018). Nevertheless, cognitive variability is smaller. Normal to low average total IQ, low verbal IQ, social problems and high levels of psychiatric comorbidities including early aggressiveness are commonly described (Hong and Reiss, 2014). In Denmark, higher risks of committing sexual crime and arson (compared to criminal controls) was recently reported (Stochholm et al., 2012). Quite a few clinically relevant cases reports scattered in the literature, suggests the presence of a pattern of a specific subtype of KS inpatients among forensic population (Bénézech, 1975). However, very few studies provide quantitative or qualitative pertaining to robust results. KS well-documented neurobiological (van Rijn, 2018) (e.g. low levels of testosterone), neuropsychological (Bénézech, 1975; Hong and Reiss, 2014; Samango-Sprouse et al., 2018; Savic, 2012; Seara-Cardoso et al., 2016; Senon, 2005; Stochholm et al., 2012; van Rijn, 2018; van Rijn et al., 2008; van Rijn et al., 2018; van Rijn et al., 2014; van Rijn et al., 2012) [29] (e.g. alterations of both complex cerebral — attention, empathy — and behavioral regulation functions - inhibition, mental flexibility, emotional response modulation, control of own actions) and neuroanatomical (Hong and Reiss, 2014; Itti et al., 2003; Savic, 2012; van Rijn et al., 2008; van Rijn et al., 2012) [29] (e.g. limbic system and temporal lobe abnormal volume, hemispheric specialization shortcoming) features may be helpful to understand comorbid symptoms psychopathology. Numbers of recent studies conduct on KS pediatric or adult population provide interesting results on conduct, anxiety, psychotic and autism spectrum disorders. In addition, some authors use genetic and epigenetic specific features of sex chromosome aneuploidies (e.g. X genes neurodevelopmental role; imprinting) in order to clarify genotype-phenotype links of comorbid symptoms (Bruining et al., 2011; Zitzmann et al., 2004;). With Belgian colleagues from the Social Defense Research Center (CRDS, Tournai, Belgium), we are currently recruiting KS inpatients from security hospitals or psychiatric units in Belgium and France. We aim to assess psychopathic traits with the Psychopathy Checklist Revised (PCL-R, Hare) (Hare, 2003). Our first results concerning 3 KS males outline that PCL-R is useful for the characterization of clinical phenotype among KS forensic sample. While three of them present psychopathic traits, two of them present categorical double diagnose “psychopathy-KS” (total PCL-R score > = 30/40 (Delannoy et al., 2017)). Moreover, dimensional analysis support our hypothesis of a higher prevalence of “explosive profile” in comparison to other psychopathic profiles in our sample (Delannoy et al., 2017). The present article summarizes historic background (e.g. “psychopathy” disappearance of mental disorder reference classification schemes, “crime chromosome” (Bénézech, 1975)) and current context argues (e.g. French psychiatrists court experts widely refer to psychopathy concept despite a lack of consensual definition (Senon, 2005), weak knowledge and training of PCL-R and its related biopsychological recent findings (Blair, 2013; de Oliveira-Souza et al., 2008; Dotterer et al., 2017; Glenn and Raine, 2014; Hosking et al., 2017; Korponay et al., 2017; Pham, 1995; Pham, 2005; Raine, 2008; Raine et al., 2003); stigma and discrimination apprehensions of KS and psychopath) that motivate our research project. Finally, we discuss the advantages of our research protocol on KS participants assessed with PCL-R, such as tackling stigma and discrimination, better understanding psychopathology, and clarifying murky interactions of biological, psychological and social factors entangled in the development of these two fascinating troubles. 相似文献
3.
4.
5.
6.
Leonidas JC; Berdon WE; Valderrama E; Neveling U; Schuval S; Weiss SJ; Hilfer C; Godine L 《Radiology》1996,198(2):377
7.
JC Sitek† M Loeb‡ JR Ronnevig¶ 《Journal of the European Academy of Dermatology and Venereology》2007,21(7):891-896
BACKGROUND: Since 1997, a number of trials have shown promising results in treating generalized vitiligo with narrowband ultraviolet B (UVB) both in adults and children. However, there is little knowledge concerning the duration and permanency of the treatment-induced repigmentation. OBJECTIVE: Our main objective was to perform a follow-up trial of successfully treated patients receiving narrowband UVB for generalized vitiligo. METHODS: We have investigated to what degree the treatment-induced repigmentation remains stable for up to 2 years post-treatment. We performed an initial open trial including 31 patients with generalized vitiligo. They received narrowband UVB thrice weekly for up to 12 months. Patients experiencing > 75% repigmentation were defined responders and were included in the follow-up trial. Responders were followed every 6 months for up to 2 years after cessation of treatment. We observed the pigmentation status and registered any changes indicating loss of pigmentation and relapse. RESULTS: Eleven of the 31 treated patients were included in the follow-up trial. Six patients had relapse and five patients had stable response 24 months after cessation of treatment. Four out of six relapses were within 6 months post-treatment. CONCLUSION: In our study population of 31 patients with generalized vitiligo, five patients (16%) experienced > 75% stable repigmentation 2 years after cessation of a treatment programme of up to 1 years narrowband UVB therapy. 相似文献
8.
Ongoing pregnancies after intracytoplasmic injection using cryopreserved testicular spermatozoa 总被引:4,自引:2,他引:2
Perraguin-Jayot S; Audebert A; Emperaire JC; Parneix I 《Human reproduction (Oxford, England)》1997,12(12):2706-2709
We report two clinical pregnancies occurring after intracytoplasmic sperm
injection (ICSI) using cryopreserved spermatozoa obtained from testicular
biopsy, made in two different infertility situations in our clinic. The
first patient showed a secretory azoospermia associated with elevated serum
follicular stimulating hormone (FSH) level and spermiogenesis maturation
arrest. The second patient was affected by azoospermia resulting from
bilateral epididymal obstruction. Spermatozoa present in the wet
preparation of testicular biopsy made on the day of scrotal exploration
were cryopreserved within the testicular tissue for both men.
Intracytoplasmic injections were performed at a later date, using
spermatozoa prepared from frozen-thawed tissues. In each case, three
embryos were obtained and transferred in utero. The transfers resulted in a
twin pregnancy for the first case, and in a singleton pregnancy for the
second. Living foetuses were seen in the ultrasound scan at the 7th week
and both pregnancies are proceeding to date beyond 30 weeks without
complications.
相似文献
9.
10.