ABSTRACT. Occupational and physical therapy professionals are natural partners in neurorehabilitation especially in the acute stages of recovery. To enhance student-learning experiences from both disciplines, we have developed an interprofessional (IP) learning unit that was embedded in neurorehabilitation tracks of each respective program. The primary goal of this project was to examine interprofessional attitudes and perception toward interprofessional learning and practice. A total of 117 occupational therapy (53) and physical therapy (64) students completed an IP case-based learning module with the goal of developing an IP care plan typically seen in neurorehabilitation. Using a sequential explanatory mixed methods design, we collected data pre- and postintervention using the Readiness for Interprofessional Learning Survey (RIPLS). We also utilized a postintervention questionnaire and focus groups intended to solicit information regarding IP competencies. At pretest, students had high ratings on the RIPLS that led to minimal changes at posttest (p = .157). However, common threads from the questionnaire and focus groups showed positive effects on student learning and attitudes toward interprofessionalism. Students reported positive experiences with the IP module. An IP case-based educational module has the potential to facilitate professional development and readiness for future IP practice. Students from different disciplines appreciate the value of IP education (IPE) in reinforcing their professional identity and understanding the professional contributions of others. Our findings are consistent with literature on best practices for IPE. 相似文献
Background: Virtually nothing is known about the ability of Tagalog speakers with agrammatic aphasia to cope with basic grammatical features of their language. Tagalog is unusual in exhibiting competing transitive patterns thanks to a system of voice that can make either of the verb’s arguments syntactically prominent – a prerequisite for undergoing syntactic operations such as relativisation.
Aims: Our objective is to investigate the nature of the syntactic impairment associated with agrammatic aphasia in Tagalog, with special attention to voice patterns and relative clauses (RCs).
Methods and Procedures: Five native Tagalog-speaking patients diagnosed with agrammatism took part in (1) elicited-production and (2) comprehension tasks to assess their ability with respect to voice patterns and (3) elicited-production, (4) imitation, and (5) comprehension tasks to assess their performance on RCs.
Outcomes and Results: Although the participants did poorly on grammatical morphemes, the classic symptom of agrammatism, their impairment was somewhat less severe in patterns involving verb–agent–patient order, the patient-voice in declarative clauses, and the agent voice in RCs.
Conclusions: Our findings reveal a departure from a general cross-linguistic tendency to favour agent-prominent constructions (e.g., the active voice in languages like English), as shown by the participants’ greater accuracy on patient voice declaratives than on their agent voice counterparts. Nonetheless, we found evidence of a subject preference in RCs, consistent with reports of a similar advantage in many other languages. 相似文献
The ability to appropriately integrate and respond to rewarding and aversive stimuli is essential for survival. The ventral pallidum (VP) plays a critical role in processing both rewarding and aversive stimuli. However, the VP is a heterogeneous structure, and how VP subpopulations integrate into larger reward networks to ultimately modulate these behaviors is not known. We identify a noncanonical population of glutamatergic VP neurons that play a unique role in responding to aversive stimuli and constraining inappropriate reward seeking.
Methods
Using neurochemical, genetic, and electrophysiological approaches, we characterized glutamatergic VP neurons (n = 4–8 mice/group). We performed patch clamp and in vivo electrophysiology recordings in the lateral habenula, rostromedial tegmental nucleus, and ventral tegmental area to determine the effect of glutamatergic VP neuron activation in these target regions (n = 6–10 mice/group). Finally, we selectively optogenetically stimulated glutamatergic VP neurons in a real-time place preference task and ablated these neurons using a virally expressed caspase to determine their necessity for reward seeking.
Results
Glutamatergic VP neurons exhibit little overlap with cholinergic or gamma-aminobutyric acidergic markers, the canonical VP subtypes, and exhibit distinct membrane properties. Glutamatergic VP neurons innervate and increase firing activity of the lateral habenula, rostromedial tegmental nucleus, and gamma-aminobutyric acidergic ventral tegmental area neurons. While nonselective optogenetic stimulation of the VP induced a robust place preference, selective activation of glutamatergic VP neurons induced a place avoidance. Viral ablation of glutamatergic VP neurons increased reward responding and abolished taste aversion to sucrose.
Conclusions
Glutamatergic VP neurons constitute a noncanonical subpopulation of VP neurons. These glutamatergic VP neurons increase activity of the lateral habenula, rostromedial tegmental nucleus, and gamma-aminobutyric acidergic ventral tegmental area neurons and adaptively constrain reward seeking. 相似文献
Systemic diseases are intrinsic factors that alter and may impair the wound healing process. Cachexia is a manifestation of systemic, often chronic, diseases and is characterised by systemic inflammation, appetite suppression and skeletal muscle wasting. Anorexia in cachectic states is commonly associated with malnutrition. Malnutrition may cause impaired healing. Therefore, it would follow that cachexia could influence wound healing because of reduced food intake. However, the lack of response to measures to reverse cachexia, such as supported nutrition, would suggest that a direct causal link between anorexia and weight loss in cachexia is too simple a model. To date, there is no published literature that examines the role of cachexia in human wound healing specifically. This article aims to demonstrate that cachexia is an intrinsic factor in wound healing. The role of the common mediators in wound healing and in cachexia are compared – specifically inflammation, including the nitric oxide synthase pathway, collagen deposition and reepithelialisation. 相似文献