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排序方式: 共有1926条查询结果,搜索用时 15 毫秒
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Biogerontology - Aging affects the energy metabolism differently in the cardiac and skeletal muscles. The study aim was to assess the effects of short-term calorie restriction (SCR) and refeeding... 相似文献
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Agata Cieślik-Bielecka Paweł Reichert Rafał Skowroński Tomasz Bielecki 《Platelets》2019,30(6):728-736
The current literature suggests that the antibacterial effect of leukocyte- and platelet-rich plasma (L-PRP) is directly related to platelet and leukocyte concentrations. The aim of this study was twofold: first, to evaluate the antimicrobial effect of L-PRP against selected bacterial strains in vitro, and second, to correlate this effect with leukocyte and platelet content in the final concentration. Blood was collected from 20 healthy males, and L-PRP, acellular plasma (AP), and autologous thrombin were consecutively prepared. Flow cytometry analysis of the blood, L-PRP, and AP was performed. The L-PRP gel, liquid L-PRP, and thrombin samples were tested in vitro for their antibacterial properties against seven selected bacterial strains using the Kirby–Bauer disk-diffusion method. There was notable antimicrobial activity against selected bacterial strains. No statistically significant correlations between antimicrobial activities and the platelet concentration in L-PRP were observed. Statistically significant positive correlations between selected leukocyte subtypes and antimicrobial activity were noted. A negative correlation was found between elevated monocyte count and antimicrobial activity of L-PRP against one bacterial strain studied. L-PRP possesses antimicrobial activity and can be potentially useful in the fight against certain postoperative infections. The bactericidal effect of L-PRP is caused by leukocytes, and there exists a relationship among selected leukocyte subtypes and L-PRP antimicrobial activity. 相似文献
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Michał Prejs Piotr Trzonkowski Agata Kot-Wasik Krystyna Dzierzbicka 《Journal of Asian natural products research》2019,21(2):178-185
New conjugates of mycophenolic acid (MPA) and adenosine derivatives were synthesized and assessed as potential immunosuppressants on Jurkat cell line and peripheral blood mononuclear cells (PBMC) from healthy donors. As compared to MPA, all compounds were found to be more active against Jurkat cell line. The antiproliferative activities were compared with MPA and adenosine, in both 2′,3′-O-isopropylidene protected and free hydroxyl groups possessing forms. The obtained results were also discussed in terms of selectivity index, defined as SI = IC50/EC50. 相似文献
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Borroto-Escuela Dasiel O. Romero-Fernandez Wilber Wydra Karolina Zhou Zilong Suder Agata Filip Malgorzata Fuxe Kjell 《Neurotoxicity research》2020,37(2):433-444
Neurotoxicity Research - Cocaine was previously shown to act at the Sigma1R which is a target for counteracting cocaine actions. It therefore becomes of interest to test if the monoamine stabilizer... 相似文献
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Cudo Andrzej Szewczyk Marta Błachnio Agata Przepiórka Aneta Jarząbek-Cudo Agnieszka 《The Psychiatric quarterly》2020,91(1):65-76
Psychiatric Quarterly - In the modern day, it is important to identify the determinants of Facebook addiction and game disorder. The main aim of our study is to examine the relationship between... 相似文献
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Agata Zamecznik Beata Kierzkowska Katarzyna Niewiadomska-Jarosik Jarosław Rycaj Beata Chodór Jerzy Stańczyk 《Pediatria polska》2014
Cardiomyopathies are a group of rare diseases of a myocardium in a pediatric population which affect 1–1.5 cases per 100 000 children. Restrictive cardiomyopathy (RCM) is the least common type, which constitutes 2–5% of all cardiomyopathies. RCM is characterized by a diastolic dysfunction which is a result of an increased stiffness of the ventricular myocardium with a normal systolic function. Differential diagnosis should include especially constrictive pericarditis. Because of a poor prognosis, it is important to diagnose patients as soon as possible and to early qualify them for a heart transplantation. 相似文献