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贾兰坡,生于1908年11月25日,卒于2001年7月8日.河北玉田县郭家屯乡刑家村人.为世界级名人,全球知名的田石器考古学家、古人类学家、第四纪地质学家.他发现三具“北京人”头盖骨,震惊中外学术界,登上世界最高学术殿堂.身为中国科学院院士,同时又是美国国家科学院外籍院士、第三世界科学院院士,著有《中国古人类大发现》等大量的学术著作,在全球享有崇高的声誉.但他正规学历不高,只有中学毕业证书,是一位罕见的、没有大学文凭、却攀登上了科学殿堂顶端的传奇人物.他为人谦虚,不事张扬.他常说自己微不足道,有时取得点学术成果也只是得益于不间断的自学积累. 相似文献
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目的探讨大黄酸对合并肝脂肪变的HBV转基因小鼠肝病恶化的防治作用。方法4周龄HBV转基因小鼠130只,高脂饲料喂养16周建立慢性HBV携带合并肝脂肪变小鼠模型;之后随机分为对照组(恢复正常饮食)、模型组(继续高脂饮食)、大黄酸组[120g/(kg·d)灌胃]、易善复组[69.2g/(kg·d)灌胃]4组,每组30只,第24和48周末每组分别处死15只,采集血清全自动生化仪检测ALT、AST、总胆固醇(Tc)、甘油三酯(TG)、空腹血糖(FPG),荧光定量PCR法测定HBV.DNA,肝组织常规HE染色观察组织学变化。结果①高脂喂养48周后小鼠肝组织可见脂肪变、小叶内淋巴细胞浸润和肝细胞气球样变,NAFLD肝组织活动度计分(NAS)接近NASH(3.58±1.44)。②肝组织光镜观察示24和48周末模型组NAS高于对照组,大黄酸组NAS无下降,易善复组48周末NAS降低。③血生化示24周时各组间TC、TG、FPG差异明显,大黄酸与易善复组均见增高的TC、TG、FPG水平下降;48周末组间TC、FPG仍保持原差异趋势。④24及48周末各组间血清HBV载量均差异明显(P〈0.05),模型组与对照组水平相似,大黄酸组变化不明显,易善复组明显低于模型组。结论高脂配方喂养HBV转基因小鼠可建立慢性HBV携带合并NASH小鼠模型,大黄酸可一定程度改善该模型的糖脂代谢,但对肝组织病变作用有限。回复正常饮食的组织学干预效应最佳。 相似文献
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和许多退了休的银发族一样,我对养生保健的兴趣越来越浓,所以很自然地,《养生月刊》就成了我最好的老师和最真诚的朋友。多年来在其教诲下,我逐渐地理解了一些有益的养生理念,摸索出适合于自己的一些养生方法并日常练习,有时还把有关体会通过刊物向别人介绍。 相似文献
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Objective To evaluate the accuracy of automated quantification of myocardial perfusion imaging (MPI) using a method based on a Western normal database for the detection of coronary artery disease (CAD) in a group of Chinese patients. Methods Seventy-two Chinese patients who underwent coronary angiography (CAG) and MPI within 3 months were recruited into this study. Eighty selected from 140 Chinese patients with low probability of CAD ( < 5% ) were enrolled into local normal database of 99Tcm-methoxyisobutylisonitrile (MIBI) MPI using Cedars quantitative perfusion SPECT (QPS) database. Two Western MPI normal databases (CSMC MibiMbiAuto and Mibimibi) were used for processing the Chinese CAD patients recruited in this study, and the results were compared with those using local normal database and visual interpretation. T-test and z-test were used for statistical analysis. Results The extent (EXT)measurement obtained from Mibimibi and local database was ( 10.73 ± 14.54)% and ( 14.22 ± 16.51 )%,respectively ( t = 7.87, P < 0.001 ); the severity (SEV) was 1.07 ± 0.93 and 1.34 ± 1.20, respectively ( t =7.45, P<0.001). The area under curve(AUC) by using EXT measurement for local database (0.85 ±0.05) was larger than that for CSMC MibiMbiAuto ( AUC = 0.72 ± 0.06, z = 2.50, P < 0.01 ) and Mibimibi ( AUC = 0.77 ± 0.06, z = 2.47, P = 0.014). The AUC of local database showed no significant difference from that of visual interpretation (AUC=0.83 ±0.05, z=0.05, P>0.05). Conclusion Quantification of MPI of our Chinese patients using Western normal database would decrease the accuracy for the detection of CAD. 相似文献
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