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1.
北京市顺义县50岁及以上人群中盲患病率调查   总被引:79,自引:13,他引:66  
目的 调查北京市顺义县50岁及以上人群盲患病率,并与1985年调查结果相比较,以此评价近10余年该县实施防盲治项目的效果。方法 1996年9~11月采用整群随机抽样方法在顺义县抽取28个调查点,对50岁及以上人群进行视力和眼部检查。正式现场调查之前先进行预试验,并进行保证调查质量的重复性检验。结果 检录5555例中,受检人数为5084例,受检率为91.5%。以世界卫生组织视力损伤为标准,盲患病率为  相似文献
2.
北京市顺义区白内障患病和手术状况的调查   总被引:48,自引:4,他引:44  
目的 调查北京市顺义区50岁及以上人群中白内障患病率、白内障盲人手术覆盖率和白内障盲人社会负担率,以此了解白内障的患病状况及评价10余年来该区实施以白内障手术治疗为主的防盲治盲工作的效果。方法 1996年9月,采用整群随机抽样方法对顺义区抽取28个调查点5084例50岁及以上人群进行视力和眼部检查,包括应用裂隙灯检查受检者晶状体;了解接受白内障手术的情况。结果 5084例受检者中,白内障患病率为23.31%。随着年龄的增加,白内障患病率明显增高。在女性和文盲者中的白内障患病率较高,分别为26.01%及37.33%;1984年后,白内障手术率持续增加,以双眼小孔视力<0.05作为盲的标准,白内障手术覆盖率为56.36%,白内障盲人的社会负担率为1.63%。以双眼日常生活视力<0.1为标准,白内障手术的覆盖率为47.79%,白内障盲人的社会负担率为2.22%。在70岁以上人群、女性和文盲者中,白内障手术覆盖率较低,分别为36.36%、44.87%及44.09%。白内障盲人的社会负担率较高,分别为6.84%、2.74%及3.90%。结论白内障仍是高龄者的致盲眼病,白内障盲人所造成的社会负担较重。在老龄、女性及文盲中因白内障引起的盲目仍是顺义区目前存在的严重问题。  相似文献
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Quantification of MUC5AC protein in human tears.   总被引:8,自引:0,他引:8  
PURPOSE: MUC5AC has been identified as a major secretory mucin of conjunctival goblet cells and precorneal tear film. However, no method has been reported to quantify MUC5AC protein in human tears. The objective of this study was to establish a method to measure the amount of MUC5AC in human tears and to correlate the amount of MUC5AC with age, gender, and dry eye diseases. METHODS: A goat antibody was raised to synthetic peptides corresponding to nonglycosylated epitopes of human MUC5AC mucin. This antibody and a horseradish peroxidase-coupled second antibody were used to develop a quantitative immunoassay to measure the MUC5AC concentration of tear samples collected on Schirmer strips. Porcine stomach mucin was used as a standard for the assay. The chemiluminescent MUC5AC signal was digitized and quantified. Tear samples from 19 healthy volunteers and 31 clinically diagnosed dry eye patients were analyzed. RESULTS: MUC5AC concentration in human tears ranged from undetectable to more than 200 microg/mL porcine stomach mucin equivalent. In the healthy population, low, moderate, and high concentrations were found in the tear samples from younger and older persons and from both men and women. The mean MUC5AC content in tears was lower in the dry eye patients than in the age- and gender-matched healthy individuals. CONCLUSIONS: A method was established to quantify MUC5AC in human tear samples obtained on Schirmer strips. There was no correlation between the amount of MUC5AC and age or gender in the healthy population. Dry eye disease patients, however, typically showed reduced concentrations of soluble MUC5AC in the tear film.  相似文献
5.
三种降眼压药物对眼部血流的影响   总被引:4,自引:0,他引:4  
目的 观察3种常用的降眼压药物连续滴用1周后对眼部血流的影响。方法 选择原发性开角型青光眼或高眼压症患者32例,分为3组,分别滴用0.5%左旋丁萘酮心安、0.5%噻吗心安及0.1%地匹福林1周,均为每日2次。将患者滴药前、后1周在激光扫描眼底镜下拍摄的荧光素、吲哚青绿视网膜和脉络膜务管造影录像带作为分析资料,利用计算机视频图像处理技术和相应测量软件,以单盲测量3组患者的眼部血流动力学目标。在正式测  相似文献
6.
Potential mechanism for the additivity of pilocarpine and latanoprost   总被引:3,自引:0,他引:3  
PURPOSE: To determine the ocular hypotensive mechanism underlying the additivity of latanoprost and pilocarpine. METHODS: This randomized, double-masked study included 30 patients with ocular hypertension on no ocular medications for at least 3 weeks. On each of six visits to the clinic, measurements were taken of aqueous flow and outflow facility by fluorophotometry, intraocular pressure by tonometry, and episcleral venous pressure by venomanometry. Uveoscleral outflow was calculated. Clinic visits were scheduled on baseline day; on day 8 of four times daily pilocarpine (2%) to one eye and vehicle to the other; on day 8 of continued pilocarpine/vehicle treatment plus latanoprost (0.005%) once daily to both eyes; after a 3-week washout period; on day 8 of once-daily latanoprost to one eye and vehicle to the other; and on day 8 of continued latanoprost/vehicle treatment plus pilocarpine four times a day to both eyes. Drug-treated eyes were compared with contralateral vehicle-treated eyes and with baseline day by paired t tests. Combined pilocarpine and latanoprost-treated eyes were compared with individual drug-treated eyes and with baseline day using the Bonferroni test. RESULTS: Compared with baseline, pilocarpine reduced intraocular pressure from 18.9 to 16.2 mm Hg (P =.001) and increased outflow facility from 0.18 to 0.23 microl per minute per mm Hg (P =.03). No other parameters were affected. Adding latanoprost further reduced intraocular pressure to 13.7 mm Hg (P <.001) and increased uveoscleral outflow from 0.82 to 1.36 microl per minute (P =.02). Latanoprost alone reduced intraocular pressure from 17.6 to 14.3 mm Hg (P <.0001) and increased uveoscleral outflow from 0.89 to 1.25 microl per minute (P =.05). Adding pilocarpine to the latanoprost treatment further reduced intraocular pressure to 12.7 mm Hg (P <.001) and increased outflow facility from 0.21 to 0.30 microl per minute per mm Hg (P =.03). CONCLUSIONS: Latanoprost and pilocarpine predominantly increase uveoscleral outflow and outflow facility, respectively, when given alone. These drugs are additive because pilocarpine does not inhibit the uveoscleral outflow increase induced by latanoprost.  相似文献
7.
核因子кB在人角膜基质细胞中的表达   总被引:2,自引:0,他引:2  
目的 探讨核因子кB(NF-кB)在人角膜基质成纤维细胞中的基础表达及激活情况。方法 取体外培养的第2或3代人角膜基质细胞,同步化后分为2组:无血清的DMEM液培养的不加药组;含质量浓度为10μg/ml脂多糖的DMEM液培养6小时的加药组。均采用免疫荧光抗体染色、流式细胞仪计数法和核蛋白提取物凝胶迁移率法检测。结果 流式细胞计数法示,角膜基质细胞内NF-кB的基础表达率为9.4%,脂多糖作用后升高  相似文献
8.
应用激光扫描眼底镜检查视网膜神经纤维层   总被引:1,自引:0,他引:1  
目的评价激光扫描眼底镜检查视网膜神经纤维层缺损的敏感性和特异性,以及其在临床上的应用价值。方法选择原发性开角型青光眼49例(95只眼),高眼压症19例(37只眼),疑似青光眼患者43例(83只眼),正常志愿者18例(34只眼)作为研究对象。所有研究对象均散瞳后应用488nm的蓝色氩激光为光源,1~3mm的共焦点光圈,获得40°和20°视角的视网膜神经纤维层图像,记录在录像带上。由具有相当经验的研究者判断有无视网膜神经纤维层缺损以及缺损类型。在回避了第一次结果的条件下,对68只眼视网膜神经纤维层的情况进行不同观察者及两次观察的重复性研究。结果两次观察和不同观察者判断有无视网膜神经纤维层缺损以及缺损类型的一致性分别为高度和中到高度。激光扫描眼底镜检查视网膜神经纤维层缺损的敏感性为80.0%,特异性为94.1%。结论激光扫描眼底镜检查视网膜神经纤维层是一种方便、快捷、准确和安全地发现视网膜神经纤维层缺损的有效方法,对于提高青光眼的早期诊断率有一定的临床实用价值。  相似文献
9.
阿普可乐定防止Nd:YAG激光虹膜切除术后眼压升高   总被引:1,自引:0,他引:1  
目的 了解阿普可乐定是否有效降低棕色虹膜人种激光肛膜切除术后眼压急性升高。方法 48只原发性闭角型青光眼,按年龄、性别进行匹配,分为治疗组和对照组。治疗组术前1小时和术后即刻滴用1%阿普可乐定,对照组滴用安慰剂。术后0.5、1.0、1.5、2.0、3.5小时观察眼压和其他情况。结果 激光治疗后,治疗组和对照组眼压最大升高值分别为0.62±0.67kPa(1kPa=7.5mmHg)和1.13±0.8  相似文献
10.
A novel microscope system is presented for observation of corneal cells in a living mouse. It enables tracking of individual cells in all layers of the cornea at various times, thus allowing the generation of time-lapse recordings. The system consists of three major components: an upright fluorescence microscope for visualization of corneal cells, a mouse-holding unit for immobilization of the animal and the eye, and a set of gimbals which permit observation of a wide area of corneal surface without refocusing. The same cells could be observed at different limes with the help of fiducial marks in the cornea, allowing their changes in position to be determined under natural and experimental conditions. This technique should prove useful in investigation of the cell movement in normal and diseased corneas, including the study of wound healing after an injury or surgery.  相似文献
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