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1.
表皮生长因子受体家族在翼状胬肉上皮内的异常表达   总被引:31,自引:0,他引:31  
目的 了解表皮生长因子受体(epidermal growth factor receptor,EGFR)家族的EGFR、ErbB2及ErbB3蛋白在翼状胬肉上皮内的表达。方法 用免疫荧光组织化学及Western blot地15例初发期翼状胬肉患者切除的翼状胬肉组织进行EGFR、ErbB2及ErbB3蛋白的检测,并与正常人结膜组织进行对照。结果 免疫荧光组织化学染色显示,在正常结膜上皮中,EGFR蛋  相似文献
2.
正常人角膜前后表面地形及全角膜厚度的研究   总被引:21,自引:2,他引:19  
目的 了解正常人的角膜前后表面形态及全角膜厚度,为诊断异常角膜提供参考依据。方法 应用Orbscan角膜地形图仪对46例正常人(46只眼)的角膜进行检测,建立其正常参数。结果正常人角膜最薄处为(0.55±0.33)mm,平均位于距视轴(0.90±0.51)mm处。32例(70%)角膜最薄点位于颞下方,11例(24%)位于颞上方,2例(4%)位于鼻下,1例(2%)位于鼻上方。角膜厚度以角膜中央最薄(0.56±0.03)mm,角膜上方最厚(0.64±0.03)mm。模拟角膜屈率(SimK)为(44.24±1.61/43.31±1.66)D,散光度为(0.90±0.41)D。角膜前表面高度地形图的图形中,岛形最多,其次为不完全嵴形。角膜后表面高度地形图的图形中,岛形最多,其次为规则嵴形及不完全嵴形。在前表面角膜屈率地形图的图形中,对称蝴蝶结形最多,其次为椭圆形及不对称蝴蝶结形。在角膜厚度彩色地形图中,椭圆形最多,其次为圆形。结论 了解正常人全角膜厚度、角膜高度形态及角膜前表面角膜屈率地形图将为诊断异常角膜提供依据。Orbscan角膜地形图仪是一种测量角膜地形及全角膜厚度的有用工具,在角膜屈光手术中将具有重要的应用价值。  相似文献
3.
目的 评价干眼病患者的角膜表面规则性及人工泪液对其角膜表面规则性的影响。方法 应用TMS 1角膜地形图仪检测正常人 33例 ( 6 4只眼 )及干眼病患者 2 2例 ( 42只眼 )的角膜表面规则指数 (surfaceregularityindex ,SRI)、表面不对称指数 (surfaceasymmetryindex ,SAI)及角膜预测视力(potentialvisualacuity ,PVA) ,并对干眼病患者应用人工泪液前后角膜表面规则性及PVA的变化进行观察。结果 干眼病患者的SRI、SAI及PVA值分别为 0 .31± 0 .2 2、0 .30± 0 .16及 2 0 /17.89± 2 0 /3.0 4;而正常人分别为 1.2 8± 0 .73、1.0 5± 1.17及 2 0 /33.45± 2 0 /13.99。干眼病患者的SRI和SAI值较正常人明显升高 ,PVA值则明显降低 ,各组间比较差异有非常显著性 (P <0 .0 0 1)。干眼病患者的平均散光度( 2 .10± 1.96 )D明显较正常人 ( 1.13± 0 .5 3)D高 (P =0 .0 2 )。在干眼病患者中 ,SRI与SAI与角膜荧光素染色程度呈正相关 (SRI:P =0 .0 0 5 ;SAI:P =0 .0 16 ) ,而平均PVA与平均实际矫正视力比较差异无显著性。干眼病患者角膜地形图中对称蝴蝶结形所占的比例较正常人明显降低 ,而不规则形者所占比例则明显升高。干眼病患者在滴用人工泪液后 ,SRI、SAI和平均散光度均明显降低 (P值分别为<0 .0 0 1,<0 .0 0  相似文献
4.
Tear function and goblet cell density after pterygium excision   总被引:2,自引:0,他引:2  
Li M  Zhang M  Lin Y  Xiao Q  Zhu X  Song S  Lin J  Chen J  Liu Z 《Eye (London, England)》2007,21(2):224-228
PURPOSE: To evaluate the short-term effect of pterygium excision on tear function and conjunctival goblet cell density. METHODS: In all, 70 patients (70 eyes) with primary pterygia who underwent a bare-sclera procedure were enrolled in this study. Tear break-up time, Schirmer, and tear-ferning tests and conjunctival goblet cell density obtained by impression cytology were evaluated before and 1 month after surgery. RESULTS: At 1 month postoperation, the tear break-up time (11.49+/-3.76 s) was significantly prolonged when compared with the preoperation tear break-up time (9.74+/-3.43 s, P=0.002). Before surgery, only 17% of the patients showed normal crystallization in the tear-ferning test. This proportion was significantly increased to 90% 1 month after surgery (P<0.001). There is no significant difference in the Schirmer test value between pre- and postsurgery (P>0.05). The mean goblet cell density in conjunctival impression specimens before surgery was 41.82+/-18.29/10 fields, which was increased significantly 1 month after surgery (P<0.001) with a mean cell density of 50.67+/-18.71/10 fields. CONCLUSION: Tear function in patients with primary pterygium improves after pterygium excision, which indicates that pterygium has a close relationship with dry eye.  相似文献
5.
目的 了解我国现代儿童和青少年眼球突出度、瞳距及眶距的发育规律及相互关系 ,为制定儿童和青少年矫治眼镜的标准提供活体参数。方法 采用随机整群抽样调查 ,对厦门 5~ 17岁的儿童和青少年进行随机整群抽样。利用游标卡尺、眼球突出计对其瞳距、眶距及眼球突出度进行活体测量。结果 眼球突出度为 (14 48± 1 71)mm ,5~ 8岁儿童的眼球突出度随年龄的增加而增大 ,9~ 17岁眼球突出度值变化趋于平稳 ;眶距为 (95 5 5± 5 32 )mm ,瞳距为 (5 6 99± 3 93)mm ,两者各年龄组的平均值男性大于女性 ,其随年龄的增加而增大 ,增长趋势呈阶段性。眶距及瞳距增长具有相关性 (r=0 9942 )。结论 儿童和青少年的眼部发育只有一个生长突增期 ,即 8岁前 ,而无第 2次生理突增期及性别交叉 ,其生长规律符合神经系统的生长发育模式。  相似文献
6.
R Chu  Y Jiang  J Zhang  M Li 《眼科学报》1990,6(3-4):95-98
The authors performed posterior scleral reinforcement operation on 23 cases of high myopia with macular degeneration. One eye underwent surgery and the another eye served as control. Follow-up period ranged from 3 to 24 months. It was found that the corrected vision and refractive degree of the operated eye maintained the original levels and that the control eyes tend to become worse during the follow-up periods. It was also observed that the blood circulation of the macular area of operated eye seemed to be improved, and the bioelectricity was activated. No serious complications were found. Therefore the authors pointed out, for high myopia patients, if the condition advanced constantly, the posterior scleral reinforcement operation is a method of choice before other better therapeutic methods are established.  相似文献
7.
目的 探讨人类白细胞抗原-DQA1和-DQB1(human leukocyte antigen-DQA1 and DQB1,HLA-DQA1andDQB1)基因与沃洛特-小柳-原田综合征(Vogt-Koyanagi-Haradasyndome,VKH)遗传易感的相关性。方法 应用聚合酶链式反应-序列特异性引物(polymerasechainreaction-sequencespecifieprin  相似文献
8.
9.
Z Zhang  M Edwards  C M Schor 《Vision research》2001,41(23):2995-3007
Computational models of stereopsis employ a number of algorithms that constrain stereo matches to produce the smallest absolute disparity and to minimize the relative disparity between nearby features. In some natural scenes, such as large slanted textured surfaces, these two constraints lead to different matching solutions. The current study utilized a stimulus in which there was a large discrepancy in both the magnitude and direction of matches that solved for minimum absolute and minimum relative disparity. This discrepancy revealed a dominance for the minimum relative disparity over the minimum absolute disparity matching solution that increased with spatial proximity, spatial frequency and width of adjacent features. The likelihood of a minimum-relative-disparity matching solution also increased when the difference between the amplitudes of the alternative relative disparities was large. When alternative relative disparity matching solutions had similar amplitudes but opposite signs (crossed vs. uncrossed), an idiosyncratic depth bias served as a tie-breaker. The present results show that absolute disparity matches are constrained to minimize relative disparity between adjacent features.  相似文献
10.
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