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准分子激光原位角膜磨镶术治疗近视   总被引:101,自引:7,他引:94  
Chen J  Wang Z  Yang B  Li S 《中华眼科杂志》1998,34(2):141-145
目的 全面评价准分子激光原位角膜磨镶术(laser in-situ keratom ileusis,LASIK)治疗近视的疗效。方法 对术前近视度为-2.00~-28.00D的患者429只眼行LASIK手术,观察12个月以上,按术前屈光度分为三组:-2.00~-8.00 D组179只眼,-8.25~-15.00 D组137只眼,-15.25~-28.00 D组113只眼,手术前后检查包括远、近视力、验光,裂隙灯和眼底检查,以及眼压、角膜知觉、对比敏感度、角膜内皮细胞照像、超声角膜测厚及角膜地形图等。手术参数包括:角膜瓣厚度130~160μm,最大切削直径5.8mm。手术后滴0.1%氟甲脱氧泼尼松龙眼液,持续1-2个月,结果 术后裸眼视力和屈光状态于1-3个月趋向稳定,角膜知觉在术后3个月时恢复术羊水平,而对比敏感度于术后3-6个月恢复正常,角膜内皮细胞密度无变化,术后12个月时,三组的屈光度在±1D以内者分别为88.8%、19.6%和70.8%,在±0.5D以内者分别为73.7%、65.0%和46.0%;裸眼视力达0.5或以上者分别为96.6%、81.8%和54.9&,达1.0或者分别为84.4%、58.4%和15.0%。结论 LASIK手术对于高、中、低度近视均可取得良好的治疗效果,手术安全,但较PRK复杂,依赖于手术者的技术,目前尚无LASIK专用程序,需对PRK程序作一定修改。  相似文献
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准分子激光屈光性角膜手术后角膜知觉的改变   总被引:22,自引:2,他引:20  
目的观察和分析准分子激光屈光性角膜切削术(photorefractivekeratectomy,PRK)和准分子激光原位角膜磨镶术(laserin-situkeratomileusis,LASIK)治疗近视后角膜知觉的变化。方法对231例(387只眼)近视患者施行PRK,对482例(796只眼)施行LASIK进行治疗。对术后角膜知觉不同时期的变化进行检查、分析。结果PRK和LASIK术后早期角膜知觉均明显下降,尤以PRK明显。PRK术后角膜知觉在术后6个月才能恢复,LASIK术后角膜知觉约在术后1个月即恢复。结论PRK术后角膜知觉的恢复比LASIK慢。  相似文献
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临时人工角膜用于严重眼外伤的眼前后段联合手术   总被引:13,自引:2,他引:11  
目的评价临时人工角膜下眼前后段联合手术对严重眼外伤病变的治疗价值。方法对眼球穿通伤所致的眼球前后段严重的病变18例(18只眼),按伤眼的适应证,施行临时人工角膜下的玻璃体切除、眼内异物取出术、视网膜复位术及相关各种眼内显微技术(视网膜前膜剥离、重水液下操作、眼内硅油填充、眼内电凝和眼内激光等)和穿透性角膜移植术或自体角膜片转位移植术,观察其术后的转归及恢复情况。结果所有术眼的眼球均得到了保留,14只眼的视力较术前提高,其中5只眼的视力达到0.1以上,3/10只眼术后再次出现视网膜脱离,2只眼出现角膜植片混浊,各有1只眼出现玻璃体混浊和继发性青光眼,其中1只眼与术前一样为眼球萎缩。结论临时人工角膜下的眼前后段联合手术是目前治疗严重眼外伤病变的唯一有效的方法  相似文献
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The expression of three aquaporin (AQP)-type water channels has been reported in the lacrimal gland: AQP5 in the apical membranes of acinar and duct cells, AQP4 in the basolateral membranes of acinar cells, and AQP1 in microvascular endothelia. Recent experiments indicate that water movement through AQP5 in the salivary gland is important in saliva secretion. To investigate the role of aquaporins in lacrimal gland function, basal and pilocarpine-stimulated tear secretion was compared in wildtype mice and knockout mice lacking AQP1, AQP4 and AQP5, as well as AQP3, which was found here to be expressed in the basolateral membrane of acinar cells. Tear fluid was collected in anesthetized mice using microcapillary tubes before and at 4 min intervals after pilocarpine administration. Tear fluid volumes were (in microliter per 4 min, S.E.): 0.69 +/- 0.06 (wildtype mice), 0.70 +/- 0.07 (AQP1 -/-), 0.81 +/- 0.13 (AQP3 -/-), 0.62 +/- 0.14 (AQP4 -/-), and 0.78 +/- 0.09 (AQP5 -/-) (differences not significant). Chloride concentrations (average 155 +/- 13 mM) measured by a fluorescence assay were also not different in tear fluid collected from wildtype vs aquaporin null mice. These findings provide direct evidence against an essential role for aquaporins in lacrimal gland fluid secretion. The requirement for aquaporins in salivary but not lacrimal gland secretion, may involve the substantially slower fluid secretion rate across lacrimal gland acinar cells.  相似文献
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蚕蚀性角膜溃疡的临床特点分析   总被引:8,自引:1,他引:7  
探讨蚕蚀性角膜溃疡患者的临床特点和比较治疗方法的效果。方法对连续治疗的蚕蚀性角膜溃疡患者550例的患病年龄,性别,眼别,溃疡部位,溃疡穿孔,溃疡复发情况,以及球结膜切除术,板层角膜移植术及板层角膜移植术联环孢霉素A滴眼的疗效进行分析情况,以及球结膜切除术,板层角膜移植术及板层角膜术联合环孢霉素A滴眼的疗效进行分析。结果平均患病年龄48.4岁;男:女之比为1:0.74;双眼患病者165例,其中青年患  相似文献
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AIMS: To investigate the clinical characteristics and compare the effects of several methods of treatment of Mooren's corneal ulcer. METHODS: 550 consecutive cases of Mooren's corneal ulcer were analysed in patients, including age, sex, laterality of eye, ulcer location, perforative rate, cure rate of surgeries, recurrent rate, the effects of conjunctiva excision, lamellar keratoplasty (LKP), and LKP plus 1% cyclosporin A eye drops. RESULTS: The average age of onset was 48.4 years of age. The ratio of males to females was 1:0. 74. 165 (30%) cases had the disease bilaterally, of which 52 (31.5%) occurred in the young age group and 113 (68.5%) in the old age group. Ulcers of 501 eyes (70.1%) were located at the limbus of the palpebral fissure. The perforation rate was 13.3%, with perforation of 41 eyes (43.2%) occurring in the young age group and 54 (56.8%) in the old age group. Postoperative recurrence rate was 25.6%. The cure rate of the first procedure of LKP plus 1% cyclosporin A eye drops was 73.7%. The final cure rate was 95.6%, and the postoperative preservation rate of the eye globe was 99.7%. CONCLUSION: This primary study provided the clinical characteristics of patients with Mooren's corneal ulcer in China. LKP plus 1% cyclosporin A eye drops was an effective treatment.  相似文献
7.
基因重组人表皮生长因子治疗兔角膜损伤的研究   总被引:3,自引:0,他引:3  
目的 探讨基因重组人表皮生长因子(rhEGF)对治疗角膜损伤的疗效。方法 新西兰白兔24只,全麻下切除角膜前板层,直径8mm,约1/3角膜厚度。将其随机均分为4组,每组6只(12只眼),分别滴1、10、100μg/ml rhEGF液,对照组滴生理盐水,每天4次,共7天。用计算机图像处理测量角膜损伤面积。结果 1、10、100μg/ml rhEGF治疗组角膜上皮愈合速率分别为9.31、9.96、9.  相似文献
8.
A study on the pathologic findings after recession and resection of extraocular muscles in rabbits was performed. Fibrosis of the extraocular muscles increased with time, which showed no difference between the recessed and resected muscles. Inflammation and foreign body reaction decreased with time, which showed no difference between the recessed and resected muscles. Adhesions of extraocular muscles to the sclera were observed from one month after the operation. The resected muscles showed milder adhesion to the sclera than the recessed ones. The operated extraocular muscles showed atrophies at one month, which showed no difference between the recessed and resected muscles. According to our results, when reoperation is needed, fibrosis of the extraocular muscles after recession and resection should be considered when making a decision on the amount of muscle to be recessed and resected.  相似文献
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The purpose of this study was to evaluate the accuracy of intraocular pressure (IOP) and ocular pulse rate (OPR) measurements obtained by the Ocular Blood Flow (OBF) tonograph (OBF Labs, Wiltshire, UK). Measurements of IOP and OPR by the OBF tonograph were compared to those of reference instruments. For IOP evaluation, measurements were obtained on patients with normal and abnormal pressures using the OBF tonograph and the Goldmann applannation tonometer in random alternate order. For the OPR evaluation, measurements were obtained using the OBF tonograph with simultaneous heart rate monitoring by ECG on patients with normal IOP. The validity of the OBF tonograph measurements was quantified in terms of 95% limits of agreement and their relationships to measurements by reference instruments was determined by linear regression analyses. 102 patients were recruited for IOP measurements. Mean IOP obtained by the Goldmann tonometer was 20.7 mmHg (7-42 mmHg, SD 6.98) whilst mean IOP obtained by the OBF tonograph was 20.1 mmHg (8.1-40.2, SD 6.1). Goldmann IOP and OBF tonograph IOP readings were well correlated (r = 0.945). Analysis of the difference in IOP measurements between two instruments (tonograph minus Goldmann tonometer) showed the mean bias to be 0.26 mmHg (-7.8 to +6.1 mmHg) and the 95% limits of agreement to be -4.35 to +4.87 mmHg. Agreement between two instruments appeared to be dependent on the IOP; at IOP lower than 20.6 mmHg there was an overall tendency for the tonograph IOP to be higher than Goldmann IOP and vice versa when IOP was above 20.6 mmHg. 47 patients were recruited for OPR and ECG measurements. Mean pulse rates were 74.8 beats per min (mean 43-110) by ECG and 73.9 beats per min (43-110) by tonography. Analysis of the difference in pulse rate between instruments (tonograph OPR minus ECG pulse rate) against the average pulse rate showed the mean bias to be -0.8 beats and the 95% limits of agreement to be between -7 to +5 beats. Ocular pulse rate values obtained by the OBF tonograph were very accurate when compared to ECG pulse rate. This indicates that there is unlikely to be a systematic lag in continuous ocular pulse waveform recording. Intraocular pressure measurements by the OBF tonograph correlated very well with Goldmann readings over a wide range of pressures and should be valid in the clinical setting.  相似文献
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