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1.
准分子激光原位角膜磨镶术治疗近视   总被引:101,自引:7,他引:94  
Chen J  Wang Z  Yang B  Li S 《中华眼科杂志》1998,34(2):141-145
目的 全面评价准分子激光原位角膜磨镶术(laser in-situ keratom ileusis,LASIK)治疗近视的疗效。方法 对术前近视度为-2.00~-28.00D的患者429只眼行LASIK手术,观察12个月以上,按术前屈光度分为三组:-2.00~-8.00 D组179只眼,-8.25~-15.00 D组137只眼,-15.25~-28.00 D组113只眼,手术前后检查包括远、近视力、验光,裂隙灯和眼底检查,以及眼压、角膜知觉、对比敏感度、角膜内皮细胞照像、超声角膜测厚及角膜地形图等。手术参数包括:角膜瓣厚度130~160μm,最大切削直径5.8mm。手术后滴0.1%氟甲脱氧泼尼松龙眼液,持续1-2个月,结果 术后裸眼视力和屈光状态于1-3个月趋向稳定,角膜知觉在术后3个月时恢复术羊水平,而对比敏感度于术后3-6个月恢复正常,角膜内皮细胞密度无变化,术后12个月时,三组的屈光度在±1D以内者分别为88.8%、19.6%和70.8%,在±0.5D以内者分别为73.7%、65.0%和46.0%;裸眼视力达0.5或以上者分别为96.6%、81.8%和54.9&,达1.0或者分别为84.4%、58.4%和15.0%。结论 LASIK手术对于高、中、低度近视均可取得良好的治疗效果,手术安全,但较PRK复杂,依赖于手术者的技术,目前尚无LASIK专用程序,需对PRK程序作一定修改。  相似文献
2.
准分子激光屈光性角膜手术后角膜知觉的改变   总被引:22,自引:2,他引:20  
目的观察和分析准分子激光屈光性角膜切削术(photorefractivekeratectomy,PRK)和准分子激光原位角膜磨镶术(laserin-situkeratomileusis,LASIK)治疗近视后角膜知觉的变化。方法对231例(387只眼)近视患者施行PRK,对482例(796只眼)施行LASIK进行治疗。对术后角膜知觉不同时期的变化进行检查、分析。结果PRK和LASIK术后早期角膜知觉均明显下降,尤以PRK明显。PRK术后角膜知觉在术后6个月才能恢复,LASIK术后角膜知觉约在术后1个月即恢复。结论PRK术后角膜知觉的恢复比LASIK慢。  相似文献
3.
Xie L  Shi W  Wang Z  Bei J  Wang S 《Cornea》2001,20(7):748-752
PURPOSE: To test for prolongation of corneal transplant survival with cyclosporine in a polymer placed in the anterior chamber of corneal allograft recipients. METHODS: Wistar inbred rats with vascularized corneas were recipients of corneal allografts from Sprague-Dawley donor rats. Grafted rats were randomized into six groups: untreated control animals, cyclosporine-polymer anterior chamber recipients, cyclosporine-polymer subconjunctival recipients, cyclosporine-olive oil drop recipients, polymer-only anterior chamber recipients, and autografted Wistar rats. Grafts were examined by slit lamp every 3 days and the clinical condition scored. The cyclosporine concentration in the aqueous humor was assayed at 1, 2, and 4 weeks. At 2 and 4 weeks after transplantation, the eyes were collected for histopathologic evaluation of the grafts. RESULTS: The median survival time of untreated corneal allografts was 8.2 +/- 1.48 days for grafts treated with topical cyclosporine, 8.5 +/- 1.50 days for polymer-only anterior chamber implants, 10.6 +/- 1.90 days for 1% cyclosporine drops, 11.4 +/- 2.50 days for grafts given subconjunctival cyclosporine-polymer, 17 +/- 3.05 days for grafts given cyclosporine-polymer implants in the anterior chamber, and more than 3 months in autografted rats. There was a statistically significant difference ( p < 0.05) between the survival time of the allografts in the animals treated with the cyclosporine-polymer in the anterior chamber compared with the other groups of graft recipients. Significantly higher concentrations of cyclosporine were found in the eyes given an anterior chamber implant of cyclosporine-polymer than in the other treatment groups or the untreated rats. The cyclosporine-polymer implants placed in the anterior chamber induced a transient inflammatory response in transplanted eyes. CONCLUSIONS: Cyclosporine-polymer placed in the anterior chamber significantly prolongs corneal allograft survival in a high-risk corneal graft rejection. This intraocular delivery system may be a valuable adjunct for the suppression of immune graft rejection in high-risk recipients of corneal transplants.  相似文献
4.
眼内巨大异物摘出术17例临床分析   总被引:14,自引:0,他引:14  
目的讨论眼内巨大异物的定义、手术方式的选择以及提高治愈率,方法(1)经X线定位,常规经巩膜取出法;(2)间接检限镜直规定位法;(3)显微镜直视下自睫状体平坦部夹取法;(4)经前房取出法。结果17例(18只眼)均为一次手术摘出异物。联合玻璃体切除显微镜直视下摘出异物13只眼,占72.2%(二期行眼内容剜出人造骨植人术1只眼);经巩膜摘出异物5只眼。术后视力提高6只眼,不变9只眼,下降3只眼。结论异物摘出联合玻璃体切除手术损伤小、准确、安全,可减少手术开发症,提高治愈率,是值得推广的手术方式。  相似文献
5.
数字减影脑血管造影对海绵窦瘘的诊断及其血管内治疗   总被引:14,自引:0,他引:14  
目的 探讨全脑动脉数字减影血管造影(digitalsubtractionangiography,DSA)血管内治疗,对以搏动性眼球突出为主要表现的颈动脉海绵窦瘘(carotidcavemoussinusfistula,CCF)的诊断及治疗价值。方法 对15例海绵窦瘘患者行DSA,12例行可脱性球囊,微螺圈血管内栓塞治疗。结果 15例中,12例为高流量单侧颈内动脉型CCF,3例为低流量单侧颈外动脉  相似文献
6.
临时人工角膜用于严重眼外伤的眼前后段联合手术   总被引:13,自引:2,他引:11  
目的评价临时人工角膜下眼前后段联合手术对严重眼外伤病变的治疗价值。方法对眼球穿通伤所致的眼球前后段严重的病变18例(18只眼),按伤眼的适应证,施行临时人工角膜下的玻璃体切除、眼内异物取出术、视网膜复位术及相关各种眼内显微技术(视网膜前膜剥离、重水液下操作、眼内硅油填充、眼内电凝和眼内激光等)和穿透性角膜移植术或自体角膜片转位移植术,观察其术后的转归及恢复情况。结果所有术眼的眼球均得到了保留,14只眼的视力较术前提高,其中5只眼的视力达到0.1以上,3/10只眼术后再次出现视网膜脱离,2只眼出现角膜植片混浊,各有1只眼出现玻璃体混浊和继发性青光眼,其中1只眼与术前一样为眼球萎缩。结论临时人工角膜下的眼前后段联合手术是目前治疗严重眼外伤病变的唯一有效的方法  相似文献
7.
The protective effect of ascorbate in retinal light damage of rats   总被引:11,自引:0,他引:11  
Cyclic light and dark-reared rats were exposed to intense visible light for various periods and then rhodopsin-measured following recovery in darkness for up to 14 days. Animals were injected with ascorbic acid or ascorbate derivatives at various doses prior to light exposure in green Plexiglas chambers. The results show that ascorbic acid administration elevates retinal ascorbate and reduces the loss of rhodopsin and photoreceptor cell nuclei resulting from intense light. When given in comparable doses, L-ascorbic acid, sodium ascorbate, and dehydroascorbate were equally effective in preserving rhodopsin. The ascorbate protective effect in the retina is also dose dependent in both cyclic light and dark-reared rats and exhibits a requirement for the L-stereoisomer of the vitamin. Ascorbic acid is effective when administered before, but not after, light exposure, suggesting that protection from light damage in the retina occurs during the light period. In some experiments, rod outer segments were isolated from rats immediately after light exposure, lipids extracted, and fatty acid composition determined. As judged by the preservation of rod outer segment docosahexaenoic acid in rats given ascorbate, the vitamin may act in an antioxidative fashion by inhibiting oxidation of membrane lipids during intense light.  相似文献
8.
易混淆的眶尖部肿瘤的MRI特点   总被引:9,自引:1,他引:8  
分析眶尖部海绵状血管瘤、海绵状淋巴管瘤及神经鞘瘤的MRI特点,为临床诊治提供根据。方法对经MRI检查,手术及组织病理学证实的16例眶尖部肿瘤进行分析。结果3种眶尖部肿瘤的MRI的增强扫描完全强化时间不同。其中5例海绵状血管瘤所用的时间平均产为12min31s;6例海绵状淋巴管瘤所用的时间平均为7min7s;5例神经鞘瘤所用的平均时间为3min27s,差异有非常显著性,MRI增强扫描完全强化所用的时  相似文献
9.
蚕蚀性角膜溃疡的临床特点分析   总被引:8,自引:1,他引:7  
探讨蚕蚀性角膜溃疡患者的临床特点和比较治疗方法的效果。方法对连续治疗的蚕蚀性角膜溃疡患者550例的患病年龄,性别,眼别,溃疡部位,溃疡穿孔,溃疡复发情况,以及球结膜切除术,板层角膜移植术及板层角膜移植术联环孢霉素A滴眼的疗效进行分析情况,以及球结膜切除术,板层角膜移植术及板层角膜术联合环孢霉素A滴眼的疗效进行分析。结果平均患病年龄48.4岁;男:女之比为1:0.74;双眼患病者165例,其中青年患  相似文献
10.
目的了解中、晚期青光眼患者眼动脉血流情况及血管因素在中、晚期青光眼患者视功能损害机制中的作用。方法采用彩色多普勒超声检查仪测定156例中、晚期青光眼患者的眼动脉血流速度,并与正常组75例的有关参数值进行比较。结果正常组:平均最大收缩期血流速度(peaksys-tolicvelocity,PSV)为35.98±9.13cm/s,舒张期眼动脉血流速度(enddiastolicvelocity,EDV)为11.98±3.90cm/s。开角型青光眼(primaryopenangleglaucoma,POAG)组:PSV为24.13±4.65cm/s,EDV为7.10±1.85cm/s,闭角型青光眼(primarycloseangleglaucoma,PCAG)组:PSV为22.89±5.43cm/s,EDV为7.06±1.92cm/s。各组间PSV与EDV比较:POAG组与PCAG组间差异无显著性(P>0.05),青光眼组与正常组间差异有非常显著性(P<0.01)。结论中、晚期青光眼患者因眼动脉血流速度下降明显,导致局部血液循环障碍。青光眼患者的视功能损害与视神经的血供不足关系密切。  相似文献
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