全文获取类型
收费全文 | 1824篇 |
免费 | 115篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 17篇 |
儿科学 | 50篇 |
妇产科学 | 29篇 |
基础医学 | 172篇 |
口腔科学 | 117篇 |
临床医学 | 96篇 |
内科学 | 449篇 |
皮肤病学 | 31篇 |
神经病学 | 100篇 |
特种医学 | 118篇 |
外科学 | 304篇 |
综合类 | 5篇 |
一般理论 | 1篇 |
预防医学 | 64篇 |
眼科学 | 130篇 |
药学 | 76篇 |
肿瘤学 | 190篇 |
出版年
2023年 | 15篇 |
2022年 | 9篇 |
2021年 | 47篇 |
2020年 | 33篇 |
2019年 | 48篇 |
2018年 | 71篇 |
2017年 | 41篇 |
2016年 | 42篇 |
2015年 | 59篇 |
2014年 | 84篇 |
2013年 | 73篇 |
2012年 | 120篇 |
2011年 | 120篇 |
2010年 | 65篇 |
2009年 | 82篇 |
2008年 | 110篇 |
2007年 | 112篇 |
2006年 | 109篇 |
2005年 | 107篇 |
2004年 | 110篇 |
2003年 | 105篇 |
2002年 | 106篇 |
2001年 | 17篇 |
2000年 | 14篇 |
1999年 | 26篇 |
1998年 | 15篇 |
1997年 | 16篇 |
1996年 | 15篇 |
1995年 | 18篇 |
1994年 | 19篇 |
1993年 | 8篇 |
1992年 | 7篇 |
1991年 | 11篇 |
1990年 | 8篇 |
1989年 | 6篇 |
1988年 | 12篇 |
1987年 | 5篇 |
1986年 | 9篇 |
1985年 | 3篇 |
1984年 | 11篇 |
1983年 | 12篇 |
1982年 | 7篇 |
1981年 | 3篇 |
1979年 | 4篇 |
1977年 | 5篇 |
1976年 | 3篇 |
1965年 | 2篇 |
1961年 | 2篇 |
1908年 | 2篇 |
1907年 | 2篇 |
排序方式: 共有1949条查询结果,搜索用时 15 毫秒
1.
2.
Cristina Masini Maria Giuseppa Vitale Marco Maruzzo Giuseppe Procopio Ugo de Giorgi Sebastiano Buti Sabrina Rossetti Roberto Iacovelli Francesco Atzori Laura Cosmai Francesca Vignani Giuseppe Prati Sarah Scagliarini Annalisa Guida Annalisa Berselli Carmine Pinto 《Clinical genitourinary cancer》2019,17(1):e150-e155
Background
Pazopanib has been approved for first-line treatment of patients with metastatic renal-cell carcinoma on the basis of clinical trials that enrolled only patients with adequate renal function. Few data are available on the safety and efficacy of pazopanib in patients with renal insufficiency. This study investigated the effect of kidney function on treatment outcomes in such patients.Patients and Methods
We retrospectively analyzed data of metastatic renal-cell carcinoma patients treated with pazopanib from January 2010 to June 2016 with respect to renal function. Patients with Modification of Diet in Renal Disease ≤ 60 mL/min/1.73 m2 (group A) were compared to patients with Modification of Diet in Renal Disease > 60 mL/min/1.73 m2 (group B) in terms of progression-free survival, toxicities, response rates, and overall survival.Results
A total of 229 patients were included: 128 in group A and 101 in group B. Median progression-free survival was 14 months (95% confidence interval [CI], 9.4-18.5) and 17 months (95% CI, 11.4-22.8), and overall survival was 30.5 months (95% CI, 8-53) and 41.4 months (95% CI, 21-62) for group A and group B, respectively, with no significant difference (P = .6). No significant difference between the 2 groups was reported in the incidence of adverse events. Dose reductions were more frequent in group A patients (66% vs. 36%; P = .04).Conclusion
Although the dose of pazopanib was reduced more frequently in patients with renal impairment, kidney function at therapy initiation does not adversely affect the safety and efficacy of pazopanib. 相似文献3.
4.
5.
Sumanta K. Pal MD Dean Bajorin MD Nazli Dizman MD Jean Hoffman-Censits MD David I. Quinn MD Daniel P. Petrylak MD Matthew D. Galsky MD Ulka Vaishampayan MD Ugo De Giorgi MD Sumati Gupta MD Howard A. Burris MD Harris S. Soifer PhD Gary Li PhD Hao Wang PhD Carl L. Dambkowski MD Susan Moran MD Siamak Daneshmand MD Jonathan E. Rosenberg MD 《Cancer》2020,126(11):2597-2606
6.
Barone A Crespi R Aldini NN Fini M Giardino R Covani U 《The International journal of oral & maxillofacial implants》2005,20(4):519-525
PURPOSE: Implant placement in the posterior maxilla may often be contraindicated because of insufficient bone volume and the presence of the maxillary sinus. In these situations, sinus floor lifting and grafting frequently have been proposed as the best treatment. The aim of this study was to compare histologically the use of 100% autogenous bone versus a combination of autogenous bone and corticocancellous pig bone for maxillary sinus augmentation. MATERIALS AND METHODS: Eighteen patients requiring bilateral maxillary sinus augmentation were selected for this study. Bone for grafting was harvested from the iliac crest. Each patient received 100% autogenous bone in 1 randomly selected sinus (control side) and a 1:1 mixture of autogenous bone and corticocancellous pig bone particles in the contralateral sinus (test side). Five months after the augmentation procedure, bone biopsy specimens were taken at the time of implant placement. RESULTS: No complications were observed during the surgical procedures; all patients healed uneventfully. No signs or symptoms of maxillary sinus disease were observed during the 5 months after surgery. No significant differences in bone percentages were observed in the bone biopsies from test and control sides. DISCUSSION AND CONCLUSION: It could be concluded from this study that corticocancellous pig bone particles can be successfully used in a 1:1 mixture with autogenous bone from the iliac crest for maxillary sinus augmentation in cases of severely atrophic maxilla. 相似文献
7.
Fabrizio Di Francesco Gennaro De Marco Ugo Antonello Gironi Carnevale Michele Lanza Alessandro Lanza 《Journal of prosthodontic research》2019,63(1):15-24
Purpose
The number of implants needed to support a maxillary overdenture is still a controversial issue. The aim of this systematic review was to investigate the number of implants required to support a maxillary overdenture in order to obtain optimal treatment outcomes in terms of implant survival, overdenture longevity and patient satisfaction.Study selection
Pubmed and EMBASE databes were systematically searched and complemented by hand searching from 2000 to 2017. The Prisma statement and a PICOS approach were adopted. All selected articles provided at least two-year follow-up and 10 totally edentulous patients. Survival rate of implants and overdentures were statistically analyzed according to number of implants and according to splitting technique, employing non-parametric Fisher Test for unpaired data. For the pooled analysis of implant failures, the odds ratio between group of 4 splinted implants and group of more than 4 splinted was calculated.Results
A total of 28 articles were included. Data analysis of the included studies showed that the survival rate of implants appeared higher in ≥ 4 implants group, whereas the high survival rate of overdentures and patient satisfaction were not significantly influenced by the number of implants.Conclusions
The findings of our analysis indicate that overall the most frequent tendency is to place at least four implants, splinted or unsplinted, in order to ensure a higher survival rate of implants. However, the relationship between overdenture survival, the patient’s quality of life, and the number of implants required to support a maxillary overdenture has yet to be clarified. 相似文献8.
Alveolar distraction osteogenesis for the correction of vertically deficient edentulous ridges: a multicenter prospective study on humans 总被引:6,自引:0,他引:6
Chiapasco M Consolo U Bianchi A Ronchi P 《The International journal of oral & maxillofacial implants》2004,19(3):399-407
PURPOSE: The purposes of this prospective multicenter study were to evaluate the use of vertical distraction osteogenesis in the correction of vertically deficient alveolar ridges and to evaluate whether the vertical bone gained by distraction osteogenesis was maintained over time when dental implants were placed in the distracted areas. MATERIALS AND METHODS: Thirty-seven patients presenting vertically deficient edentulous ridges were treated in 4 different centers by means of distraction osteogenesis with an intraoral alveolar distractor. Two to 3 months after consolidation of the distracted segments, 138 dental implants were placed in the distracted areas. Four to 6 months later, abutments were connected and prosthetic loading of the implants began. RESULTS: The mean follow-up after initial prosthetic loading was 34 months (range 15 to 55 months). The mean bone gain obtained by distraction was 9.9 mm (range 4 to 15 mm). The cumulative success rate of the implants 4 years after the onset of prosthetic loading was 94.2%, while the implants' cumulative survival rate was 100%. No statistically significant differences were found between the different centers as far as survival and success rates of implants were concerned. DISCUSSION AND CONCLUSION: The results of this study appear to demonstrate that distraction osteogenesis is a reliable technique for the correction of vertically deficient edentulous ridges. The regenerated bone appeared to withstand the functional demands of implant loading. The survival and success rates of the implants placed in the distracted areas were consistent with those reported in the literature regarding implants placed in native bone in this patient population. 相似文献
9.
We report a case of giant spermatic cord liposarcoma (SCL) in an 81-year-old patient, presenting with a huge scrotal mass that reached up to the knee joint. SCL is a rare tumor, and about 200 cases have been reported in the literature so far. Although 20% of liposarcomas arise in the retroperitoneum, only 0.1% present as incidental inguinal hernias. The occasional presence of myxoid stroma in well-differentiated liposarcomas can lead to confusion with myxoid sarcoma subtypes. Correct diagnosis is critical and reflects remarkable differences in behavior and therapeutic choices.Key words: Liposarcoma, Spermatic cord, Scrotal massSpermatic cord liposarcoma (SCL) is a very rare tumor, and about 200 cases have been described in the literature up to date. Clinically, these tumors can sometimes mimic the common scrotal masses such as hernias, testicular cancer, and hydrocele. Their histologic heterogeneity reflects remarkable differences in both prognosis and treatment. We report a case of SCL in an 81-year-old patient presenting with a huge scrotal mass. 相似文献
10.
Marcello Giuseppe Spampinato Andrea Coratti Luigi Bianco Fabio Caniglia Andrea Laurenzi Francesco Puleo Giuseppe Maria Ettorre Ugo Boggi 《Surgical endoscopy》2014,28(10):2973-2979