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排序方式: 共有102条查询结果,搜索用时 15 毫秒
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Riffat Naz Asma Gul Urooj Javed Alina Urooj Sidra Amin Zareen Fatima 《Reviews in medical virology》2019,29(2)
Respiratory infections, especially those of the lower respiratory tract, remain a foremost cause of mortality and morbidity of children greater than 5 years in developing countries including Pakistan. Ignoring these acute‐level infections may lead to complications. Particularly in Pakistan, respiratory infections account for 20% to 30% of all deaths of children. Even though these infections are common, insufficiency of accessible data hinders development of a comprehensive summary of the problem. The purpose of this study was to determine the prevalence rate in various regions of Pakistan and also to recognize the existing viral strains responsible for viral respiratory infections through published data. Respiratory viruses are detected more frequently among rural dwellers in Pakistan. Lower tract infections are found to be more lethal. The associated pathogens comprise respiratory syncytial virus (RSV), human metapneumovirus (HMPV), coronavirus, enterovirus/rhinovirus, influenza virus, parainfluenza virus, adenovirus, and human bocavirus. RSV is more dominant and can be subtyped as RSV‐A and RSV‐B (BA‐9, BA‐10, and BA‐13). Influenza A (H1N1, H5N1, H3N2, and H1N1pdm09) and Influenza B are common among the Pakistani population. Generally, these strains are detected in a seasonal pattern with a high incidence during spring and winter time. The data presented include pneumonia, bronchiolitis, and influenza. This paper aims to emphasise the need for standard methods to record the incidence and etiology of associated pathogens in order to provide effective treatment against viral infections of the respiratory tract and to reduce death rates. 相似文献
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Sidra Javed 《Current oncology (Toronto, Ont.)》2021,28(1):440
Prostate cancer can masquerade as just normocytic anemia and thrombocytopenia, thrombotic thrombocytopenic purpura (TTP), hemolytic uremic syndrome (HUS), or tumor lysis syndrome (TLS). We are reporting an intriguing case of metastatic prostate cancer which remained undiagnosed until the patient showed signs of tumor lysis syndrome (TLS), leading to urate nephropathy requiring urgent hemodialysis. Tumor lysis syndrome is an oncological emergency but an exceedingly rare complication in non-hematological malignancies, including prostate cancer. It is challenging to recognize features of TLS in a case such as this with an unknown diagnosis. In the case of an established diagnosis of malignancy, however, checking baseline renal function, uric acid, lactate dehydrogenase (LDH), potassium, and phosphate to monitor for TLS as well as considering urate lowering therapy can help prevent adverse outcomes. 相似文献
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Elis R. Dalla Costa Sidra E. G. Vasconcelos Leonardo S. Esteves Harrison M. Gomes Lia L. Gomes Pedro Almeida da Silva Jo?o Perdig?o Isabel Portugal Miguel Viveiros Ruth McNerney Arnab Pain Taane G. Clark Nalin Rastogi Gisela Unis Maria Lucia R. Rossetti Philip Noel Suffys 《Journal of clinical microbiology》2015,53(12):3805-3811
We recently detected the spoligotype patterns of strains of Mycobacterium pinnipedii, a species of the Mycobacterium tuberculosis complex, in sputum samples from nine cases with pulmonary tuberculosis residing in Porto Alegre, South Brazil. Because this species is rarely encountered in humans, we further characterized these nine isolates by additional genotyping techniques, including 24-locus mycobacterial interspersed repetitive-unit–variable-number tandem-repeat (MIRU-VNTR) typing, verification of the loci TbD1, RD9, pks15/1, RDRio, and fbpC, the insertion of IS6110 at a site specific to the M. tuberculosis Latin American Mediterranean (LAM) lineage, and whole-genome sequencing. The combined analysis of these markers revealed that the isolates are in fact M. tuberculosis and more specifically belong to the LAM genotype. Most of these isolates (n = 8) were shown to be multidrug resistant (MDR), which prompted us to perform partial sequencing of the rpoA, rpoB, rpoC, katG, and inhA genes. Seven isolates (77.8%) carried the S315T mutation in katG, and one of these (11%) also presented the C(−17)T single-nucleotide polymorphism (SNP) in inhA. Interestingly, six of the MDR isolates also presented an undescribed insertion of 12 nucleotides (CCA GAA CAA CCC) in codon 516 of rpoB. No putative compensatory mutation was found in either rpoA or rpoC. This is the first report of an M. tuberculosis LAM family strain with a convergent M. pinnipedii spoligotype. These spoligotypes are observed in genotype databases at a modest frequency, highlighting that care must be taken when identifying isolates in the M. tuberculosis complex on the basis of single genetic markers. 相似文献
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Sidra Ishaque Taimur Saleem Waris Qidwai 《BMC complementary and alternative medicine》2009,9(1):32-17
Background
Gemstones have been in use as part of alternative and complementary medicine for years. However, our understanding of the perceived healing powers of gemstones is limited. An extensive literature search revealed that there is a dearth of validated information on this subject. This study was therefore undertaken to explore the various aspects of the knowledge, attitudes, and practices of the public towards gemstone therapeutics. 相似文献8.
Geoff Lucas Steven Culliford Frances Green Gamal Sidra Anthony Calvert Ann Green Penny Harrison John Harvey Dave Allen David Smillie Ashish Masurekar David Marks Nigel Russell Edwin Massey 《Transfusion》2010,50(2):334-339
BACKGROUND: Patients with human platelet antigen (HPA) specific antibodies in cases of neonatal alloimmune thrombocytopenia and platelet (PLT) refractoriness derive clinical benefit from the use of HPA‐selected PLTs. STUDY DESIGN AND METHODS: This study describes three patients with underlying diagnoses of acute myeloid leukemia, chronic lymphocytic leukemia, and myelodysplasia, respectively, who underwent allogeneic bone marrow transplantation (BMT) with unrelated donors matched at the HLA‐A, B, C, Dr, and DQ loci but who failed to achieve an adequate PLT count. Investigation using PLT immunofluorescence test, monoclonal antibody immobilization of PLT antigens assay, and genotyping revealed the presence of recipient‐derived HPA‐1a antibodies. RESULTS: In two patients, anti‐HPA‐1a was detected post‐BMT and in the third patient, anti‐HPA‐1a was detected during pre‐BMT chemotherapy. Despite apparent 100% engraftment of donor cells, the patients' PLT counts failed to recover 9‐10 months posttransplant. The patients remained PLT‐transfusion dependent and failed to achieve satisfactory increments following random donor or HLA‐matched PLT transfusions. After the identification of HPA‐1a antibodies, the patients were supported by HPA‐1a(‐) PLTs and satisfactory posttransfusion PLT increments were obtained. These cases illustrate that HPA‐1a antibodies may remain detectable for 10 months following apparently successful donor engraftment and the disappearance of recipient‐derived HLA antibodies. The prolonged persistence of recipient‐derived PLT‐specific antibodies following BMT has to our knowledge not been described previously. CONCLUSION: HPA‐1a antibodies were associated with protracted PLT‐transfusion dependence and significant hemorrhagic complications. Appropriate and timely laboratory investigation for HPA‐specific antibodiesfollowed by transfusion support with HPA‐selected PLTs provided the cornerstone of the hemostatic management in these cases. 相似文献
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Taimur Saleem Sidra Ishaque Nida Habib Saadia Syedda Hussain Areeba Jawed Ali Aamir Khan Muhammad Imran Ahmad Mian Omer Iftikhar Hamza Pervez Mughal Imtiaz Jehan 《BMC medical ethics》2009,10(1):5