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1.
抗青光眼滤过术后超声乳化白内障吸除术的临床观察   总被引:31,自引:0,他引:31  
目的 探讨抗青光眼滤过手术后进行白内障手术的方法及手术对滤过泡的影响。方法对抗青光眼小梁切除术后白内障患者 2 35例 (2 6 2只眼 ) ,采用颞侧透明角膜隧道切口进行超声乳化白内障吸除及折叠式人工晶状体植入手术 ,同时对固定的小瞳孔进行扩张或采用括约肌切开与缝合术。结果 白内障术后患者视力不同程度提高 ,视力≥ 0 5者占 74 0 % ;术后平均眼压升高 3 0 8mmHg(1mmHg =0 133kPa) ,与术前比较差异无显著性 (P >0 0 5 ) ;功能性滤过泡未见明显瘢痕化。结论 对抗青光眼滤过术后白内障患者进行颞侧透明角膜隧道切口超声乳化白内障吸除术 ,可提高视力 ,同时可保持滤过泡功能。  相似文献
2.
BACKGROUND: Pterygium is a relatively common eye disease in the tropics whose aetiology and pathogenesis remain uncertain. As such, interest has focused on understanding the underlying mechanism of pterygia development. METHODS: 15 specimens of pterygia from 15 eyes were examined, together with normal conjunctival tissue from the same eyes for the pattern of gene expression of genes associated with the induction or repression of apoptosis (p53, bcl-2, and bax). In addition, the samples directly for apoptotic cells were examined by the terminal deoxynucleotide transferase (TdT) mediated nick end labelling (TUNEL) methodology. RESULTS: In pterygia specimens apoptotic cells were found mainly confined to the basal layer of cells of the epithelial layer, situated immediately adjacent to the fibrovascular support layer. These cells were shown to express significant levels of p53 and bax, as well as the apoptosis inhibiting protein bcl-2. In contrast, normal conjunctival specimens displayed no bcl-2 expression and apoptotic cells were seen throughout the entire width of the epithelial layer, coupled with high levels of bax expression. CONCLUSION: These results support a model whereby pterygia development is a result of disruption of the normal process of apoptosis occurring in the conjunctiva.  相似文献
3.
目的 探讨经颞侧透明角膜隧道切口的超声乳化白内障吸出及折叠式人工晶体植入术的效果及其优,缺点。方法 用钻石刀在颞侧角膜周边血管弓中央的透明角膜上,做一深0.30mm,宽1.75mm和内口长3.20mm,外口长3.50mm的梯形角膜隧道切口,对812例(845只眼)老年性白内障施行超声乳化白内障吸出及折叠式人工晶体植入术,术后观察视力,角膜地形图,角膜散光及角膜内皮的变化。结果 术后第1天和1个月,  相似文献
4.
目的 评价弹性开放襻一体型前房型人工晶状体(anter chamber intraocular lens,AC-IOL)植入式的疗效及其安全性。方法 应用超声生物显微镜观察20例(20只眼)弹性开放襻一体型AC-IOL植入术后患者IOL襻的位置,以及其与虹膜及房角结构的关系,从而评价IOL对眼前段结构的影响。随访时间6~20个月。结果 40个IOL襻中,26个襻固定于房角隐窝;14个襻(8只眼)穿过虹膜侵入至睫状体实质内,并伴有反复发作的葡萄膜炎。术后8只眼虹膜前粘连与IOL襻有关。结论 超声生物显微镜检查是动态了解IOL对眼前段结构影响的有效方法。AC-IOL襻的设计有待进一步改进。  相似文献
5.
Liu Y  Luo L  He M  Liu X 《Eye (London, England)》2004,18(9):900-904
PURPOSE: To evaluate the function of the blood-aqueous barrier after phacoemulsification with implantation of a foldable intraocular lens (IOL) in diabetic patients. METHODS: All patients were enrolled from those scheduled for phacoemulsification with intraocular lens implantation in Zhongshan Ophthalmic Center Guangzhou from March 2002 to June 2002. The classification on diabetic retinopathy (DR) was based on the fundus examination after cataract surgery. The blood-aqueous barrier function was examined using the laser flare cell meter (Kowa FC-2000) preoperatively and on postoperative days 1, 7, 30, and 90 by an independent examiner who was masked to the DR classification. Patients were operated by one experienced surgeon as per standard clinical protocol and were provided the same postoperative medical care. A linear regression and Wilcoxon test were used for the analysis. RESULTS: A total of 112 patients were divided into three groups: patients without diabetic mellitus as normal control (n=56), diabetic patients without diabetic retinopathy (n=2), with nonproliferation diabetic retinopathy (NPDR) (n=37), and diabetic patients with proliferation diabetic retinopathy (PDR) (n=17). All patients were examined and successfully followed up for 3 months after cataract surgery. Aqueous flare mean photon counts in PDR, NPDR, and control eyes were 8.94+/-0.57, 7.03+/-0.27, and 6.94+/-0.34 before surgery and increased to 32.42+/-0.67, 26.07+/-0.83, 26.27+/-1.37 on the first day after surgery (P<0.05), then decreased to 19.86+/-0.78, 14.08+/-0.54 and 13.96+/-1.05 at 7 days after surgery (P<0.05), 13.24+/-0.29, 9.86+/-0.33, and 9.07+/-0.43 at 30 days after surgery (P<0.05); eventually, the counting decreased to 11.25+/-0.31, 7.24+/-0.67, and 7.16+/-0.27 at 90 days after surgery (P<0.05). Linear regression model suggested that other potential variables, such as age, sex, eye (left/right), phaco time, phaco energy, and hypertension were not related to the outcome. For patients without diabetes mellitus and diabetic patients with NPDR, highly statistically significant differences (P<0.05) were found between preoperative flare value and those measured on days 1, 7, and 30 after surgery, but no statistically significant differences (P>0.05) were found between the preoperative flare value and those measured on postoperative days 90. However, patients with PDR still had a higher flare value even on postoperative day 90. The patients with intraoperative iris prolapse had a higher flare value between days 1 and 7 postoperatively. CONCLUSION: Phacoemulsification with a foldable intraocular lens implantation affects the blood-aqueous barrier more severely in diabetic patients with PDR than patients with NPDR and nondiabetic patients.  相似文献
6.
锗132对体外培养翼状胬肉成纤维细胞的增殖抑制作用观察   总被引:6,自引:0,他引:6  
观察锗132对体外培养翼状胬肉成纤维细胞的抗增殖作用,寻找辅助治疗翼状胬肉和预防翼状胬肉复发的新方法。方法将翼状胬肉成纤维细胞行体外原代和传代培养;观察不同浓度锗132及丝裂霉素C对成纤维细胞生长曲线的影响及培养的翼状胬肉成纤维细胞增殖抑制作用和毒性作用;采用免疫组织化学方法检测增殖细胞核抗原(proliferating cell nuclear antigen,PCNA)的表达,结果锗132可抑  相似文献
7.
目的观察不同浓度的碱性成纤维细胞生长因子(basic fibroblast growth f  相似文献
8.
PURPOSE: To investigate the degree of heteroplasmy of the 11778 mtDNA mutation in Chinese patients with Leber's hereditary optic neuropathy (LHON). METHODS: Seventeen Chinese Leber's pedigrees, including 24 patients, 17 unaffected maternal lineages, 4 internal controls, and 6 unrelated controls, were screened for the 11778 mtDNA mutation. This was carried out by analysis of the restriction fragment length polymorphism, single-strand conformation polymorphism, and DNA sequencing. RESULTS: All patients and unaffected maternal lineages, regardless of their symptoms, had homoplastic 11778 mtDNA mutation, which was revealed by restriction fragment length polymorphism analysis and single-strand conformation polymorphism analysis. CONCLUSION: Exclusive homoplasmy of the 11778 mtDNA mutation in Chinese LHON patients was found in this study. Homoplasmy of the 11778 mtDNA mutation cannot account for the variation in the clinical phenotype of Chinese Leber's patients.  相似文献
9.
体外培养大鼠白内障模型晶状体的早期生化改变   总被引:4,自引:0,他引:4  
目的 进一步探讨白内障的发生机制。方法 采用器官培养方法,以不同浓度亚硒酸钠及半乳糖作用于晶状体,诱发大鼠晶状体形成白是,在培养初期测定晶状体内非蛋白质疏基(nonproteinsulfhydryl,NP-SH)、蛋白质疏基(protein sulfhydryl,P-SH)和不溶性蛋白质二硫键的含量,脂类过氧化水平,以及与谷胱甘肽代谢有关的谷胱甘肽过氧化物酶(GSH peroxidase,GSH-  相似文献
10.
出血性视网膜脱离的发生原因   总被引:2,自引:2,他引:0  
出血性视网膜脱离(hemorrhagicretinaldetachment,HRD)源于脉络膜和/或视网膜循环的破坏,病因复杂。它既可为独立的病变单独出现,也是眼外伤、眼部手术、多种视网膜脉络膜疾病或全身性疾病的严重并发症。  相似文献
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