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Ioana A Campean 《Expert opinion on pharmacotherapy》2020,21(10):1193-1200
ABSTRACT
Introduction
Despite an increasingly older pulmonary hypertension (PH) population, data on PH treatments in these patients are limited because there exist no clinical studies dedicated to geriatric groups. Furthermore, elderly patients with comorbidities have been systematically excluded from clinical trials, limiting the evidence base for drugs approved for pulmonary arterial hypertension (PAH). 相似文献2.
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Pseudoaneurysm in the Mitral–Aortic Intervalvular Fibrosa—Case Report and Literature Review 下载免费PDF全文
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Psychiatric Quarterly - Patients diagnosed with unipolar disorder usually experience impaired cognitive functioning during an acute depressive episode. The purpose of the current study was to... 相似文献
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Oana Nicoară-Farcău Ioana Rusu Horia Stefănescu Marcel Tanțău Radu Ion Badea Bogdan Procopeț 《World journal of gastroenterology : WJG》2020,26(22):3000-3011
Non-cirrhotic portal hypertension consists of a group of diseases characterized by signs and complications of portal hypertension,which differ from cirrhosis through histological alterations,hemodynamic characterization and, clinical outcome.Because of the similarities in clinical presentation and imaging signs,frequently these patients,and particularly those with porto-sinusoidal vascular disease(PSVD), are misdiagnosed as having liver cirrhosis and thus raising difficulties in their diagnosis.The most challenging differentiation to be considered is between PSVD and cirrhosis and, although not pathognomonic,liver biopsy is still the standard of diagnosis.Although they still require extended validation before being broadly used,new non-invasive methods for the diagnosis of porto-sinusoidal vascular disease,like transient elastography,contrast-enhanced ultrasound or metabolomic profiling,have shown promising results.Another issue is the differentiation between PSVD and chronic extrahepatic portal vein obstruction,especially now when it is known that 40% of patients suffering from PSVD develop portal vein thrombosis.In this particular case,once the portal vein thrombosis occurred,the diagnosis of PSVD is impossible according to the current guidelines.Moreover,so far,the differentiation between PSVD and sinusoidal obstruction syndrome has not been dear so far in particular circumstances.In this review we highlighted the diagnostic challenges regarding the PSVD, as well as the current techniques used in the evaluation of these patients. 相似文献
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Rana Jahanban‐Esfahlan Khaled Seidi Maryam Majidinia Ansar Karimian Bahman Yousefi Seyed Mohammad Nabavi Akram Astani Ioana Berindan‐Neagoe Diana Gulei Francesca Fallarino Marco Gargaro Giorgia Manni Matteo Pirro Suowen Xu Mahmoud Sadeghi Seyed Fazel Nabavi Samira Shirooie 《Reviews in medical virology》2019,29(4)
Seropositivity for HSV reaches more than 70% within the world population, and yet no approved vaccine exists. While HSV1 is responsible for keratitis, encephalitis, and labialis, HSV2 carriers have a high susceptibility to other STD infections, such as HIV. Induction of antiviral innate immune responses upon infection depends on a family of pattern recognition receptors called Toll‐like receptors (TLR). TLRs bridge innate and adaptive immunity by sensing virus infection and activating antiviral immune responses. HSV adopts smart tricks to evade innate immunity and can also manipulate TLR signaling to evade the immune system or even confer destructive effects in favor of virus replication. Here, we review mechanisms by which HSV can trick TLR signaling to impair innate immunity. Then, we analyze the role of HSV‐mediated molecular cues, in particular, NF‐κB signaling, in promoting protective versus destructive effects of TLRs. Finally, TLR‐based therapeutic opportunities with the goal of preventing or treating HSV infection will be discussed. 相似文献
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