全文获取类型
收费全文 | 3318篇 |
免费 | 257篇 |
国内免费 | 66篇 |
专业分类
耳鼻咽喉 | 45篇 |
儿科学 | 104篇 |
妇产科学 | 51篇 |
基础医学 | 410篇 |
口腔科学 | 154篇 |
临床医学 | 388篇 |
内科学 | 660篇 |
皮肤病学 | 31篇 |
神经病学 | 183篇 |
特种医学 | 351篇 |
外科学 | 357篇 |
综合类 | 144篇 |
预防医学 | 255篇 |
眼科学 | 175篇 |
药学 | 233篇 |
中国医学 | 1篇 |
肿瘤学 | 99篇 |
出版年
2021年 | 62篇 |
2020年 | 29篇 |
2019年 | 42篇 |
2018年 | 48篇 |
2017年 | 48篇 |
2016年 | 39篇 |
2015年 | 79篇 |
2014年 | 63篇 |
2013年 | 108篇 |
2012年 | 136篇 |
2011年 | 124篇 |
2010年 | 95篇 |
2009年 | 88篇 |
2008年 | 134篇 |
2007年 | 155篇 |
2006年 | 152篇 |
2005年 | 143篇 |
2004年 | 125篇 |
2003年 | 111篇 |
2002年 | 101篇 |
2001年 | 93篇 |
2000年 | 78篇 |
1999年 | 63篇 |
1998年 | 85篇 |
1997年 | 87篇 |
1996年 | 83篇 |
1995年 | 90篇 |
1994年 | 60篇 |
1993年 | 60篇 |
1992年 | 64篇 |
1991年 | 53篇 |
1990年 | 63篇 |
1989年 | 77篇 |
1988年 | 75篇 |
1987年 | 72篇 |
1986年 | 49篇 |
1985年 | 66篇 |
1984年 | 44篇 |
1983年 | 52篇 |
1982年 | 29篇 |
1981年 | 31篇 |
1980年 | 33篇 |
1979年 | 19篇 |
1978年 | 20篇 |
1977年 | 23篇 |
1976年 | 16篇 |
1972年 | 18篇 |
1971年 | 18篇 |
1970年 | 19篇 |
1968年 | 18篇 |
排序方式: 共有3641条查询结果,搜索用时 93 毫秒
1.
Megan Smith-Uffen Nicci Bartley Grace Davies Megan Best 《Patient education and counseling》2021,104(6):1325-1334
ObjectivesSingle-gene testing is associated with psycho-social challenges for cancer patients. Genomic testing may amplify these. The aim of this study was to understand patients’ motivations and barriers to pursue cancer genomic testing, to enable healthcare providers to support their patients throughout the testing process and interpretation of test results.MethodsFive databases were searched for original peer reviewed research articles published between January 2001 and September 2018 addressing motivation for genomic cancer testing. QualSyst was used to assess quality.Results182 studies were identified and 17 were included for review. Studies were heterogenous. Both somatic and germline testing were included, and 14 studies used hypothetical scenarios. 3249 participants were analyzed, aged 18 to 94. Most were female and white. The most common diagnoses were breast, ovarian, lung and colorectal cancer. Interest in testing was high. Motivations included ability to predict cancer risk, inform disease management, benefit families, and understand cancer. Barriers included concerns about cost, privacy/confidentiality, clinical utility, and psychological harm.ConclusionsDespite concerns, consumers are interested in cancer genomic testing if it can provide actionable results for themselves and their families.Practice ImplicationsProviders must manage understanding and expectations of testing and translate genetic information into health-promoting behaviours. 相似文献
2.
Gary N. McAuliffe Susan L. Taylor Sharon Moore Joanne Hewitt Arlo Upton Anna S. Howe Emma J. Best 《Diagnostic microbiology and infectious disease》2019,93(3):203-207
Rotavirus vaccine has reduced disease prevalence in many countries. Consequently, we aimed to assess the reliability of a rotavirus immunoassay in the community population of Auckland and Northland, New Zealand. Between 22 October 2015 and 31 December 2016, 2873 fecal samples were tested by enzyme immunoassay (EIA, Rotascreen II, Microgen, UK) from 2748 patients (median age 8?years, range 0–101?years). Eighty-nine (3.1%) samples were reactive; 86 samples were tested by a second method. Rotavirus was confirmed in 49/86 (57%). Positive rotavirus EIAs were more likely to be confirmed in samples from cases ≥1?year of age (positive predictive value [PPV] 61%, 95% confidence interval [CI] 50–72%, P?=?0.049) and in spring/summer (PPV 67%, 95% CI 55–78%, P?=?0.003). Reactive rotavirus tests required confirmatory testing regardless of demographic, vaccine, or seasonal factors; a review of rotavirus testing algorithms may be necessary in other vaccinated community populations. 相似文献
3.
Usha Chakravarthy Natasha Pillai Annie Syntosi Lorna Barclay Catherine Best Alexandros Sagkriotis 《Eye (London, England)》2020,34(12):2249
Background/objectivesTo investigate the association between optical coherence tomography (OCT) markers of lesion activity and changes in visual acuity (VA) during anti-vascular endothelial growth factor (anti-VEGF) therapy of eyes diagnosed with neovascular age-related macular degeneration (nAMD); and how VA and OCT markers are considered in physicians’ decision to retreat with anti-VEGFs.Subjects/methodsRetrospective, non-comparative, non-randomised cohort study involving electronic medical record data collected from 1190 patient eyes with nAMD diagnosis at two sites in the United Kingdom. Two sub-cohorts consisting of 321 and 301 eyes, respectively, were selected for analyses.ResultsIn 321 eyes, absence of IRF or SRF at ≥2 clinic visits resulted in a gain of five ETDRS letters from baseline, compared with two letters gained in eyes with <2 clinic visits with absence of IRF (p = 0.006) or SRF (p = 0.042). Anti-VEGF treatment was administered at 421 clinic visits, and 308 visits were without treatment. Comparing treatment visits with non-treatment visits, the maximum difference in frequency of OCT markers of lesion activity were for intraretinal fluid (IRF; 24% versus 5%) and subretinal fluid (SRF; 32% versus 5%). Pigment epithelial detachment (PED) was reported in 58% of treatment visits compared with 36% in non-treatment visits. VA loss was not a consistent trigger for retreatment as it was present in 63% of injection visits and in 49% of non-injection visits.ConclusionsRetreatment decision making is most strongly influenced by the presence of IRF and SRF and less by the presence of PED or VA loss.Subject terms: Outcomes research, Macular degeneration 相似文献
4.
5.
6.
7.
8.
Comparison of VivaSight double‐lumen tube with a conventional double‐lumen tube in adult patients undergoing video‐assisted thoracoscopic surgery 下载免费PDF全文
The efficiency of a double‐lumen tube depends on its position in the airways, which can be verified by fibreoptic bronchoscopy. The VivaSight DL is a single‐use double‐lumen tube with a camera embedded in the tube's right side. The view from the camera appears continuously on a monitor. In this prospective study of 71 adult patients, we compared intubation times using either the VivaSight DL or a conventional double‐lumen tube. Median (IQR [range]) duration of intubation with visual confirmation of tube position was significantly reduced using the VivaSight DL compared with the conventional double‐lumen tube (51 (42–60 [35–118]) s vs 264 (233–325 [160–490]) s, respectively, p < 0.0001). None of the patients allocated to the VivaSight DL required fibreoptic bronchoscopy during intubation or surgery. The VivaSight DL enables significantly more rapid intubation compared with the conventional double‐lumen tube. 相似文献
9.
HL Robbins M Hetzel S Mungall SJ Cawthorn 《Annals of the Royal College of Surgeons of England》2015,97(1):e1-e2
Tuberculous mastitis is rare, especially in Western countries. We describe a case where the interferon gamma release assay blood test led to diagnosis and successful treatment of the disease. 相似文献
10.
Anusha Ganeshalingham David Buckley Ian Shaw Joshua T Freeman Francessa Wilson Emma Best 《Journal of paediatrics and child health》2014,50(1):78-80
Anaerobic meningitis in infants is rare, therefore a high index of clinical suspicion is essential as routine methods for processing cerebrospinal fluid (CSF) do not detect anaerobes and specific antimicrobial therapy is required. We present an infant with Escherichia coli meningitis where treatment‐resistance developed in association with culture negative purulent CSF. These features should have alerted us to the presence of anaerobes, prompting a search for the causes of polymicrobial meningitis in infants. 相似文献