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排序方式: 共有9678条查询结果,搜索用时 15 毫秒
1.
Chalub Lucas Orbolato Nunes Gabriel Pereira Ferrisse Túlio Morandin Strazzi-Sahyon Henrico Badaoui Dos Santos Paulo Henrique Gomes-Filho João Eduardo Cintra Luciano Tavares Angelo Sivieri-Araujo Gustavo 《Clinical oral investigations》2022,26(4):3343-3356
Clinical Oral Investigations - The objective of this systematic review and meta-analysis (SRM) was to answer the question whether the use of ultrasonic irrigation (UI) results in less postoperative... 相似文献
2.
Alberto D’Angelo Navid Sobhani Stefan Bagby Andrea Casadei-Gardini Giandomenico Roviello 《Expert review of clinical pharmacology》2020,13(6):623-629
ABSTRACT
Introduction
Hepatocellular carcinoma (HCC) is one of the most frequent tumors affecting the gastrointestinal tract and a universal cause of morbidity and mortality. Cabozantinib is a strong multi-inhibitor of receptor tyrosine kinases approved for renal cell carcinoma that could be useful also for the treatment of HCC. 相似文献3.
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6.
Olivari Davide De Giorgio Daria Staszewsky Lidia Irene Fumagalli Francesca Boccardo Antonio Novelli Deborah Manfredi Martina Babini Giovanni Luciani Anita Ruggeri Laura Magliocca Aurora Zani Davide Danilo Masson Serge Belloli Angelo Pravettoni Davide Maiocchi Giuseppe Latini Roberto Ristagno Giuseppe 《Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy》2022,36(4):727-738
Cardiovascular Drugs and Therapy - Available animal models of acute heart failure (AHF) and their limitations are discussed herein. A novel and preclinically relevant porcine model of decompensated... 相似文献
7.
Vassiliki A. Papadimitrakopoulou MD Ji-Youn Han MD PhD Myung-Ju Ahn MD PhD Suresh S. Ramalingam MD Angelo Delmonte MD PhD Te-Chun Hsia MD Janessa Laskin MD Sang-We Kim MD PhD Yong He MD Chun-Ming Tsai MD Toyoaki Hida MD PhD Makoto Maemondo MD PhD Terufumi Kato MD Suzanne Jenkins DPhil Sabina Patel PhD Xiangning Huang PhD Gianluca Laus MD Aleksandra Markovets PhD Kenneth S. Thress PhD Yi-Long Wu MD Tony Mok MD 《Cancer》2020,126(2):373-380
8.
Long noncoding RNAs have been recently demonstrated to have an important role in fundamental biological processes, and their deregulated expression has been found in several human neoplasias. Our group has
recently reported a drastic overexpression of the long noncoding RNA (lncRNA) RPSAP52 (ribosomal protein SA pseudogene 52) in pituitary adenomas. We have shown that this lncRNA increased cell proliferation
by upregulating the expression of the chromatinic proteins HMGA1 and HMGA2, functioning as a competing endogenous RNA (ceRNA) through competitively binding to microRNA-15a (miR-15a), miR-15b, and
miR-16. The aim of this work was to identify further mechanisms by which RPSAP52 overexpression could
contribute to the development of pituitary adenomas. We investigated the involvement of RPSAP52 in the
modulation of the expression of cell cycle-related genes, such as p21Waf1/CIP, whose deregulation plays a
critical role in pituitary cell transformation. We report that RPSAP52, interacting with the RNA binding protein
HuR (human antigen R), favors the delocalization of miR-15a, miR-15b, and miR-16 on the cyclin-dependent
kinase inhibitor p21Waf1/CIP1 that, accordingly, results in downregulation in pituitary adenomas. A RNA
immunoprecipitation sequencing (RIPseq) analysis performed on cells overexpressing RPSAP52 identified 40
messenger RNAs (mRNAs) enriched in Argonaute 2 (AGO2) immunoprecipitated samples. Among them, we
focused on GAS8 (growth arrest-specific protein 8) gene. Consistently, GAS8 expression was downregulated
in all the analyzed pituitary adenomas with respect to normal pituitary and in RPSAP52-overepressing cells,
supporting the role of RPSAP52 in addressing genes involved in growth inhibition and cell cycle arrest to
miRNA-induced degradation. This study unveils another RPSAP52-mediated molecular mechanism in pituitary tumorigenesis. 相似文献
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10.
Danilo Menicucci Andrea Piarulli Marco Laurino Andrea Zaccaro Jacopo Agrimi Angelo Gemignani 《Journal of sleep research》2020,29(5)
We investigated changes of slow‐wave activity and sleep slow oscillations in the night following procedural learning boosted by reinforcement learning, and how these changes correlate with behavioural output. In the Task session, participants had to reach a visual target adapting cursor's movements to compensate an angular deviation introduced experimentally, while in the Control session no deviation was applied. The task was repeated at 13:00 hours, 17:00 hours and 23:00 hours before sleep, and at 08:00 hours after sleep. The deviation angle was set at 15° (13:00 hours and 17:00 hours) and increased to 45° (reinforcement) at 23:00 hours and 08:00 hours. Both for Task and Control nights, high‐density electroencephalogram sleep recordings were carried out (23:30?19:30 hours). The Task night as compared with the Control night showed increases of: (a) slow‐wave activity (absolute power) over the whole scalp; (b) slow‐wave activity (relative power) in left centro‐parietal areas; (c) sleep slow oscillations rate in sensorimotor and premotor areas; (d) amplitude of pre‐down and up states in premotor regions, left sensorimotor and right parietal regions; (e) sigma crowning the up state in right parietal regions. After Task night, we found an improvement of task performance showing correlations with sleep slow oscillations rate in right premotor, sensorimotor and parietal regions. These findings suggest a key role of sleep slow oscillations in procedural memories consolidation. The diverse components of sleep slow oscillations selectively reflect the network activations related to the reinforced learning of a procedural visuomotor task. Indeed, areas specifically involved in the task stand out as those with a significant association between sleep slow oscillations rate and overnight improvement in task performance. 相似文献