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Cherie Rushton Andrew Jackson Kathryn Goddard Arun Alfred 《Journal of clinical apheresis》2019,34(1):73-74
Extracorporeal photopheresis (ECP) is a cell based immunomodulatory therapy in which the patient is attached intravenously to a cell separating machine. During ECP a patient's blood is collected via either a central venous access device (CVAD) or a peripherally inserted 16G arterial venous fistula needle in either one or both antecubital fossa. However, patients presenting for ECP with GVHD repeatedly present a challenge to the ECP team due to poor venous access resulting from previous therapies and skin changes. The use of peripherally inserted central venous catheters (PICCs) offers an alternative route of vascular access for this cohort of patients. Here we present a case report of a patient successfully treated with ECP following the insertion of a PICC line. 相似文献
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Rebecca K. Papas Benson N. Gakinya Michael M. Mwaniki Hana Lee Alfred K. Keter Steve Martino Debra A. Klein Tao Liu Michelle P. Loxley John E. Sidle Kathryn Schlaudt Tobista Nafula Victor M. Omodi Joyce B. Baliddawa Daniel W. Kinyanjui Stephen A. Maisto 《Addiction (Abingdon, England)》2021,116(2):305-318
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Wen Chen Yun Zhao Xing Xie Jihong Liu Jingran Li Chao Zhao Shaoming Wang Xueyan Liao Qiong Shou Minghuan Zheng Alfred J Saah Lihui Wei Youlin Qiao 《Vaccine》2019,37(6):889-897
Background
A quadrivalent human papillomavirus (qHPV) vaccine (HPV6/11/16/18) has demonstrated efficacy and acceptable safety in international studies. However, these studies did not include participants from mainland China, which has a substantial burden of HPV-related disease. This is the first safety report with a follow-up period of up to 90?months from a randomized, double-blind, placebo-controlled trial of qHPV vaccine in Chinese women 20–45?years of age.Methods
Participants were randomized 1:1 to receive three doses of qHPV vaccine or placebo (Day 1, Month 2, and Month 6). Efficacy outcomes are reported elsewhere. Injection-site and systemic adverse events (AEs) were collected using vaccination report cards (VRCs) for 15?days following each vaccination. Serious AEs (SAEs), pregnancy outcomes, new medical conditions, and fetal/infant SAEs were collected during the entire study.Results
Of 3006 participants randomized, AEs were reported by 926 (61.8%) qHPV vaccine recipients and 856 (57.1%) placebo recipients over the entire study. Four participants (two in each group) discontinued the study vaccination due to AEs that were considered vaccination-related. Within 15?days following any vaccination, injection-site AEs prompted for on the VRC were more frequent among qHPV vaccine recipients (37.6% vs 27.8%), and systemic AEs prompted for on the VRC were similar in frequency between qHPV vaccine and placebo groups (46.8% vs 45.1%). Thirty-eight and 43 participants reported SAEs in qHPV vaccine and placebo groups, respectively. No SAE was considered qHPV vaccine-related. Pregnancy outcomes, fetal/infant SAEs, and new medical conditions were generally similar in frequency between the qHPV vaccine and placebo groups, and within normal ranges.Conclusion
The qHPV vaccine was well tolerated and demonstrated a favorable safety profile in Chinese women 20–45?years of age, consistent with findings from global trials and safety surveillance studies.Trial registration: clinicaltrials.gov; NCT00834106. 相似文献7.
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