全文获取类型
收费全文 | 274篇 |
免费 | 11篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 7篇 |
妇产科学 | 9篇 |
基础医学 | 38篇 |
临床医学 | 19篇 |
内科学 | 63篇 |
皮肤病学 | 10篇 |
神经病学 | 26篇 |
外科学 | 25篇 |
预防医学 | 23篇 |
眼科学 | 6篇 |
药学 | 32篇 |
肿瘤学 | 24篇 |
出版年
2023年 | 3篇 |
2022年 | 2篇 |
2021年 | 20篇 |
2020年 | 11篇 |
2019年 | 15篇 |
2018年 | 7篇 |
2017年 | 7篇 |
2016年 | 5篇 |
2015年 | 8篇 |
2014年 | 11篇 |
2013年 | 18篇 |
2012年 | 34篇 |
2011年 | 21篇 |
2010年 | 17篇 |
2009年 | 7篇 |
2008年 | 23篇 |
2007年 | 26篇 |
2006年 | 18篇 |
2005年 | 15篇 |
2004年 | 7篇 |
2003年 | 5篇 |
2002年 | 4篇 |
2001年 | 1篇 |
1999年 | 1篇 |
排序方式: 共有286条查询结果,搜索用时 250 毫秒
1.
2.
A randomized controlled trial of fentanyl in the pre‐emptive treatment of pain associated with turning in patients under mechanical ventilation: research protocol 下载免费PDF全文
3.
Josué Hernando MD DDS PhD Pablo Aguirre MD Antonio Aguilar-Salvatierra DDS PhD Ignacio Osoitz Leizaola-Cardesa DDS PhD Ainhoa Bidaguren MD Gerardo Gómez-Moreno DDS PhD 《Journal of surgical oncology》2020,121(2):244-248
The aim was to evaluate sentinel node detection capacity by means of a magnetic probe in 11 patients with oral squamous cell carcinoma at stages T1-T2 received submucosal injections of a superparamagnetic iron oxide contrast agent (SPIO). A magnetic probe was used for sentinel node biopsy. The use of SPIO and magnetic probes in the early stages of oral cancer may offer an alternative to conventional radioisotope techniques and/or elective neck dissection. 相似文献
4.
Alejandro?álvaro-Meca María?A.?Jiménez-Sousa Dariela?Micheloud Ainhoa?Sánchez-Lopez María?Heredia-Rodríguez Eduardo?Tamayo Salvador?Resino 《Population health metrics》2018,16(1):4
Background
Sepsis has represented a substantial health care and economic burden worldwide during the previous several decades. Our aim was to analyze the epidemiological trends of hospital admissions, deaths, hospital resource expenditures, and associated costs related to sepsis during the twenty-first century in Spain.Methods
We performed a retrospective study of all sepsis-related hospitalizations in Spanish public hospitals from 2000 to 2013. Data were obtained from records in the Minimum Basic Data Set. The outcome variables were sepsis, death, length of hospital stay (LOHS), and sepsis-associated costs. The study period was divided into three calendar periods (2000–2004, 2005–2009, and 2010–2013).Results
Overall, 2,646,445 patients with sepsis were included, 485,685 of whom had died (18.4%). The incidence of sepsis (events per 1000 population) increased from 3.30 (2000–2004) to 4.28 (2005–2009) to 4.45 (2010–2013) (p?<?0.001). The mortality rates from sepsis (deaths per 10,000 population) increased from 6.34 (2000–2004) to 7.88 (2005–2009) to 7.89 (2010–2013) (p?<?0.001). The case fatality rate (CFR) or proportion of patients with sepsis who died decreased from 19.1% (2000–2004) to 18.4% (2005–2009) to 17.9% (2010–2013) (p?<?0.001). The LOHS (days) decreased from 15.9 (2000–2004) to 15.7 (2005–2009) to 14.5 (2010–2013) (p?<?0.001). Total and per patient hospital costs increased from 2000 to 2011, and then decreased by the impact of the economic crisis.Conclusions
Sepsis has caused an increasing burden in terms of hospital admission, deaths, and costs in the Spanish public health system during the twenty-first century, but the incidence and mortality seemed to stabilize in 2010–2013. Moreover, there was a significant decrease in LOHS in 2010–2013 and a decline in hospital costs after 2011.5.
Palomino-Bautista Carlos Sánchez-Jean Rubén Carmona-González David Piñero David P. Molina-Martín Ainhoa 《International ophthalmology》2020,40(2):351-359
International Ophthalmology - To evaluate different intraocular lens (IOL) designs and to determine whether extended depth of focus (EDOF) lenses provide a higher depth of field (DOF) than the rest... 相似文献
6.
7.
Axel R. Concepcion January T. Salas Elena Sáez Sarai Sarvide Alex Ferrer Ainhoa Portu Iker Uriarte Sandra Hervás-Stubbs Ronald P.J. Oude Elferink Jesús Prieto Juan F. Medina 《Oncotarget》2015,6(30):28588-28606
Primary biliary cirrhosis (PBC) is a chronic cholestatic disease of unknown etiopathogenesis showing progressive autoimmune-mediated cholangitis. In PBC patients, the liver and lymphocytes exhibit diminished expression of AE2/SLC4A2, a Cl−/HCO3− anion exchanger involved in biliary bicarbonate secretion and intracellular pH regulation. Decreased AE2 expression may be pathogenic as Ae2a,b−/− mice reproduce hepatobiliary and immunological features resembling PBC. To understand the role of AE2 deficiency for autoimmunity predisposition we focused on the phenotypic changes of T cells that occur over the life-span of Ae2a,b−/− mice. At early ages (1-9 months), knockout mice had reduced numbers of intrahepatic T cells, which exhibited increased activation, programmed-cell-death (PD)-1 expression, and apoptosis. Moreover, young knockouts had upregulated PD-1 ligand (PD-L1) on bile-duct cells, and administration of neutralizing anti-PD-L1 antibodies prevented their intrahepatic T-cell deletion. Older (≥10 months) knockouts, however, showed intrahepatic accumulation of cytotoxic CD8+ T cells with downregulated PD-1 and diminished apoptosis. In-vitro DNA demethylation with 5-aza-2′-deoxycytidine partially reverted PD-1 downregulation of intrahepatic CD8+ T cells from aged knockouts. Conclusion: Early in life, AE2 deficiency results in intrahepatic T-cell activation and PD-1/PD-L1 mediated deletion. With aging, intrahepatic CD8+ T cells epigenetically suppress PD-1, and their consequential expansion and further activation favor autoimmune cholangitis. 相似文献
8.
9.
10.
Maite Cruz Piqueras Ainhoa Rodríguez García de Cortazar Joaquín Hortal Carmona Javier Padilla Bernáldez 《Gaceta sanitaria / S.E.S.P.A.S》2019,33(1)