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排序方式: 共有872条查询结果,搜索用时 15 毫秒
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Anne-Laure Lapeyraque Nastya Kassir Yves Théorêt Maja Krajinovic Marie-José Clermont Catherine Litalien Véronique Phan 《Pediatric nephrology (Berlin, Germany)》2014,29(6):1081-1088
Background
The objectives of this study were to investigate pharmacokinetic and pharmacogenetic parameters during the conversion on a 1:1 (mg:mg) basis from a twice-daily (Prograf) to once-daily (Advagraf) tacrolimus formulation in pediatric kidney transplant recipients.Methods
Twenty-four-hour pharmacokinetic profiles were analyzed before and after conversion in 19 stable renal transplant recipients (age 7–19 years). Tacrolimus pharmacokinetic parameters [area under the concentration-time curve (AUC0–24), minimum whole-blood concentration (Cmin), maximum whole-blood concentration (Cmax), and time to achieve maximum whole-blood concentration (tmax)] were compared between Tac formulations and between CYP3A5 and MDR1 genotypes after dose normalization.Results
Both AUC0–24 and Cmin decreased after conversion (223.3 to 197.5 ng.h/ml and 6.5 to 5.6 ng/ml; p?=?0.03 and 0.01, respectively). However, the ratio of the least square means (LSM) for AUC0–24 was 90.8 %, with 90 % CI limits of 85.3 to 96.7 %, falling within bioequivalence limits. The CYP3A5 genotype influences the dose-normalized Cmin with the twice-daily formulation only.Conclusions
Both tacrolimus formulations are bioequivalent in pediatric renal recipients. However, we observed a decrease in AUC0–24 and Cmin after the conversion, requiring close pharmacokinetic monitoring during the conversion period. 相似文献4.
Shinichi?KawadaEmail author Kouichirou?Yonemitsu Shinji?Morimoto Hiroshi?Komura Maki?Shiraishi Yukari?Tateyama Akinobu?Kamikokuryo Maiko?Arimura Hitoshi?Uchizono 《Journal of Medical Ultrasonics》2005,32(4):173-179
Purpose The current state and effectiveness of abdominal ultrasonography (US) were investigated by reviewing statistical data for
US of the kidney as part of complete medical screenings conducted at our institution between April 1994 and March 2004.
Methods Among 4339 individuals with US findings, computed tomography (CT) was performed on 129 individuals at our institution. Among
these individuals, US findings and CT diagnoses were compared and analyzed.
Results US findings indicated renal tumors in 73 of the 129 subjects, and the breakdown of CT diagnoses for these 73 individuals was
as follows: no lesion, n = 45 (61.6%); simple renal cyst, n = 13 (17.8%); complicated renal cyst, n = 5 (6.8%); suspected malignant tumor, n = 5 (6.8%); renal angiomyolipoma, n = 2 (2.7%); pelvic dilatation, n = 1 (1.4%); granuloma, n = 1 (1.4%); teratoma, n = 1 (1.4%). Magnetic resonance imaging (MRI) was performed on 4 of the 5 subjects with suspected malignant tumor, and surgery
was performed in all 4 cases with suspected kidney cancer. Kidney cancer was histopathologically confirmed in 2 patients,
resulting in a detection rate of 0.046% for kidney cancer by US as part of a complete medical screening. In the 2 patients
with kidney cancer, differentiating cystic renal cell cancer from a renal cyst was not possible based on US findings alone
in 1 patient, and no thorough examinations were performed in the 3 years leading up to surgery.
Conclusions These results suggest that additional US and thorough examinations are necessary if a lesion cannot be confirmed as a simple
renal cyst on initial US. Furthermore, to improve the skill levels of healthcare professionals who perform and interpret US,
a feedback system should be established where data related to complete medical screenings are available to the personnel involved. 相似文献
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Yasuhiro?ItoEmail author Akira?Miyauchi Minoru?Kihara Mitsuhiro?Fukushima Takuya?Higashiyama Akihiro?Miya 《World journal of surgery》2018,42(3):615-622
Introduction
Papillary thyroid carcinoma (PTC) generally shows an excellent prognosis except in cases with aggressive backgrounds or clinicopathological features. Although the cause-specific survival (CSS) of PTC patients has been extensively investigated, the overall survival (OS) of these patients is unclear. We herein investigated both the OS and CSS of a large PTC patient series.Materials and methods
We enrolled 5897 PTC patients who underwent initial surgery between 1987 and 2005 (658 males and 5339 females; median age 51 years). Their median postoperative follow-up period was 177 months. Univariate and multivariate analyses for OS and CSS assessed the effects of gender, older age (≥55 years), distant metastasis at diagnosis (M1), significant extrathyroid extension, tumor size (cutoffs 2 and 4 cm), large node metastasis (N ≥ 3 cm), and extranodal tumor extension.Results
To date, 387 patients (7%) in this series have died from various causes, including 117 (2%) due to PTC. The 10-, 15-, and 20-year OS rates are 97, 95, and 90%, respectively. Older age and M1 were important prognostic factors for OS and CSS. Older age was a more significant factor than M1 for OS and vice versa for CSS. In the older patients, M1 was a prominent prognostic factor for both OS and CSS. In the young patients, M1 had less prognostic impact than in the older patients, and the prognostic values of M1 and N ≥ 3 cm for OS and CSS were identical and similar, respectively.Conclusions
The most important prognostic value for OS was patient age, indicating that PTC is generally indolent. However, the control of distant metastasis in older patients remains a future challenge in order to further improve their OS and CSS. PTC of ≥3 cm in young patients should be carefully followed, even in the absence of metastases, and these patients should undergo aggressive therapies for recurrent lesions and metastases.6.
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Leandro Valiengo Roberta Casati Nadia Bolognini Paulo A. Lotufo Isabela M. Benseñor Alessandra C. Goulart 《Neurocase》2013,19(2):225-228
ABSTRACTAphasia is a common consequence of stroke; it is estimated that about two-thirds of aphasic patients will develop depression in the first year after the stroke. Treatment of post-stroke depression (PSD) is challenging due to the adverse effects of pharmacotherapy and difficulties in evaluating clinical outcomes, including aphasia. Transcranial direct current stimulation (tDCS) is a novel treatment that may improve clinical outcomes in the traditionally pharmacotherapy-refractory PSD. Our aim was to evaluate the safety and efficacy of tDCS for patients with PSD and with aphasia. The Stroke Aphasic Depression Questionnaire (SADQ) and the Aphasic Depression Rating Scale (ADRS) were used to evaluate the severity of PSD. The diagnoses of PSD and aphasia were confirmed by a psychiatrist and a speech-language pathologist, respectively. In this open case series, patients (n = 4) received 10 sessions (once a day) of bilateral tDCS to the dorsolateral prefrontal cortex (DLPFC) and two additional sessions after two and four weeks, for a total of 12 sessions. All patients exhibited improvement in depression after tDCS, as indicated by a decrease in SADQ (47.5%) and in ADRS (65.7%). This improvement was maintained four weeks after the treatment. In this preliminary, open-label study conducted in four PSD patients with aphasia, bilateral tDCS over the DLPFC was shown to induce a substantial mood improvement; tDCS was safe and well tolerated by every patient. Stroke patients with aphasia can be safely treated for PSD with tDCS. Sham-controlled studies are necessary to evaluate this technique further. 相似文献
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Subclinical thyroid dysfunction and psychiatric disorders: cross‐sectional results from the Brazilian Study of Adult Health (ELSA‐Brasil) 下载免费PDF全文
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