全文获取类型
收费全文 | 1256篇 |
免费 | 96篇 |
国内免费 | 15篇 |
专业分类
耳鼻咽喉 | 13篇 |
儿科学 | 84篇 |
妇产科学 | 18篇 |
基础医学 | 102篇 |
口腔科学 | 31篇 |
临床医学 | 137篇 |
内科学 | 332篇 |
皮肤病学 | 41篇 |
神经病学 | 28篇 |
特种医学 | 162篇 |
外科学 | 149篇 |
综合类 | 73篇 |
一般理论 | 1篇 |
预防医学 | 71篇 |
眼科学 | 7篇 |
药学 | 75篇 |
中国医学 | 2篇 |
肿瘤学 | 41篇 |
出版年
2021年 | 11篇 |
2020年 | 14篇 |
2019年 | 20篇 |
2018年 | 17篇 |
2017年 | 21篇 |
2016年 | 25篇 |
2015年 | 31篇 |
2014年 | 39篇 |
2013年 | 38篇 |
2012年 | 34篇 |
2011年 | 38篇 |
2010年 | 60篇 |
2009年 | 48篇 |
2008年 | 37篇 |
2007年 | 50篇 |
2006年 | 40篇 |
2005年 | 38篇 |
2004年 | 29篇 |
2003年 | 33篇 |
2002年 | 32篇 |
2001年 | 27篇 |
2000年 | 20篇 |
1999年 | 25篇 |
1998年 | 52篇 |
1997年 | 42篇 |
1996年 | 42篇 |
1995年 | 28篇 |
1994年 | 38篇 |
1993年 | 37篇 |
1992年 | 28篇 |
1991年 | 21篇 |
1990年 | 30篇 |
1989年 | 32篇 |
1988年 | 26篇 |
1987年 | 22篇 |
1986年 | 20篇 |
1985年 | 19篇 |
1984年 | 13篇 |
1983年 | 16篇 |
1982年 | 21篇 |
1981年 | 11篇 |
1980年 | 22篇 |
1979年 | 12篇 |
1978年 | 9篇 |
1977年 | 18篇 |
1976年 | 13篇 |
1975年 | 13篇 |
1973年 | 5篇 |
1970年 | 6篇 |
1966年 | 5篇 |
排序方式: 共有1367条查询结果,搜索用时 15 毫秒
1.
2.
Amhezole,A Novel Fungal Secondary Metabolite from Aspergillus terreus for Treatment of Microbial Mouth Infection 下载免费PDF全文
Amani S. Awaad Hind A. AL‐Mudhayyif Monerah R. Al‐Othman Mohamed E. Zain Reham M. El‐Meligy 《Phytotherapy research : PTR》2017,31(3):395-402
Bio‐guided fractionation of Aspergillus terreus extract leads to isolation of a novel terpenoidal secondary metabolite. The isolated compound and the total alcoholic extract of Aspergillus terreus showed a remarkable activity against microbial mouth infections; namely, Candida albicans, Lactobacillus acidophilus, Streptococcus gordonii, and S. mutan. Moreover, the Minimum Inhibitory Concentration of the isolated compound was determined and showed low values. The combination of each of the alcoholic extract of A. terreus and the isolated compound Coe‐Comfort tissue conditioner inhibited the growth of Candida albicans at concentrations of 500 and 7.81 µg/mL, respectively, Lactobacillus acidophilus at concentrations of 250 and 7.81 µg/mL, respectively, Streptococcus gordonii at concentrations of 1000 and 62.50 µg/mL, respectively, and S. mutans at concentrations of 1000 and 125 µg/mL, respectively. The oral dosing of the extract and the isolated compound did not show any significant effect on the activity of alanine aminotransferase, aspirate aminotransferase, and the levels of blood urea and serum creatinine. Copyright © 2017 John Wiley & Sons, Ltd. 相似文献
3.
4.
Predicting Hip Fracture Type With Cortical Bone Mapping (CBM) in the Osteoporotic Fractures in Men (MrOS) Study 下载免费PDF全文
Graham M Treece Andrew H Gee Carol Tonkin Susan K Ewing Peggy M Cawthon Dennis M Black Kenneth ES Poole ; for the Osteoporotic Fractures in Men Study 《Journal of bone and mineral research》2015,30(11):2067-2077
Hip fracture risk is known to be related to material properties of the proximal femur, but fracture prediction studies adding richer quantitative computed tomography (QCT) measures to dual‐energy X‐ray (DXA)‐based methods have shown limited improvement. Fracture types have distinct relationships to predictors, but few studies have subdivided fracture into types, because this necessitates regional measurements and more fracture cases. This work makes use of cortical bone mapping (CBM) to accurately assess, with no prior anatomical presumptions, the distribution of properties related to fracture type. CBM uses QCT data to measure the cortical and trabecular properties, accurate even for thin cortices below the imaging resolution. The Osteoporotic Fractures in Men (MrOS) study is a predictive case‐cohort study of men over 65 years old: we analyze 99 fracture cases (44 trochanteric and 55 femoral neck) compared to a cohort of 308, randomly selected from 5994. To our knowledge, this is the largest QCT‐based predictive hip fracture study to date, and the first to incorporate CBM analysis into fracture prediction. We show that both cortical mass surface density and endocortical trabecular BMD are significantly different in fracture cases versus cohort, in regions appropriate to fracture type. We incorporate these regions into predictive models using Cox proportional hazards regression to estimate hazard ratios, and logistic regression to estimate area under the receiver operating characteristic curve (AUC). Adding CBM to DXA‐based BMD leads to a small but significant (p < 0.005) improvement in model prediction for any fracture, with AUC increasing from 0.78 to 0.79, assessed using leave‐one‐out cross‐validation. For specific fracture types, the improvement is more significant (p < 0.0001), with AUC increasing from 0.71 to 0.77 for trochanteric fractures and 0.76 to 0.82 for femoral neck fractures. In contrast, adding DXA‐based BMD to a CBM‐based predictive model does not result in any significant improvement. © 2015 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals, Inc. on behalf of the American Society for Bone and Mineral Research. 相似文献
5.
Aubé Mélanie Chua Michael DeLong Jessica McCammon Kurt Tonkin Jeremy Gilbert David Virasoro Ramón 《International urology and nephrology》2020,52(4):687-692
International Urology and Nephrology - To determine predictors for surgical complications and assess patient satisfaction after surgical treatment of Adult-Acquired Buried Penis (AABP). A... 相似文献
6.
Imaging of pediatric congenital heart disease 总被引:5,自引:0,他引:5
Tonkin IL 《Journal of thoracic imaging》2000,15(4):274-279
The evaluation of a patient with a heart murmur and congenital heart disease is diagnostically very challenging. Multiple advanced techniques aid in the diagnosis of simple and complex malformations. Interventional procedures and surgical corrections have allowed most patients to enjoy a good and productive lifestyle. 相似文献
7.
West MJ White HD Simes RJ Kirby A Watson JD Anderson NE Hankey GJ Wonders S Hunt D Tonkin AM 《Journal of hypertension》2002,20(12):2513-2517
OBJECTIVE: To determine the relative importance of recognised risk factors for non-haemorrhagic stroke, including serum cholesterol and the effect of cholesterol-lowering therapy, on the occurrence of non-haemorrhagic stroke in patients enrolled in the LIPID (Long-term Intervention with Pravastatin in Ischaemic Disease) study. DESIGN: The LIPID study was a placebo-controlled, double-blind trial of the efficacy on coronary heart disease mortality of pravastatin therapy over 6 years in 9014 patients with previous acute coronary syndromes and baseline total cholesterol of 4-7 mmol/l. Following identification of patients who had suffered non-haemorrhagic stroke, a pre-specified secondary end point, multivariate Cox regression was used to determine risk in the total population. Time-to-event analysis was used to determine the effect of pravastatin therapy on the rate of non-haemorrhagic stroke. RESULTS: There were 388 non-haemorrhagic strokes in 350 patients. Factors conferring risk of future non-haemorrhagic stroke were age, atrial fibrillation, prior stroke, diabetes, hypertension, systolic blood pressure, cigarette smoking, body mass index, male sex and creatinine clearance. Baseline lipids did not predict non-haemorrhagic stroke. Treatment with pravastatin reduced non-haemorrhagic stroke by 23% (P = 0.016) when considered alone, and 21% (P = 0.024) after adjustment for other risk factors. CONCLUSIONS: The study confirmed the variety of risk factors for non-haemorrhagic stroke. From the risk predictors, a simple prognostic index was created for non-haemorrhagic stroke to identify a group of patients at high risk. Treatment with pravastatin resulted in significant additional benefit after allowance for risk factors. 相似文献
8.
Maria HBM Lopes PhD Carlos AL D'Ancona PhD Neli RS Ortega PhD Paulo SP Silveira PhD Anna C Faleiros‐Martins PhD Heimar F Marin PhD 《International Journal of Urological Nursing》2016,10(3):146-153
Lower urinary tract dysfunctions (LUTD) restrict quality of life, resulting in decreased work productivity and emotional well‐being. However, most people are not diagnosed because they do not seek medical treatment. In addition, some facilities do not adequately train health professionals in the evaluation, diagnosis and treatment of these conditions. The study's objective was to develop a decision support system modelled on fuzzy logic that defines LUTD using the terminology of the International Continence Society. This methodological study aimed to develop a model that uses the maximum–minimum composition (max–min) of fuzzy relations that can perform differential diagnoses of LUTD. The model was tested in 100 cases (50 men and 50 women), and the data were obtained from medical records containing the clinical data and results of urodynamic studies. All medical records were reviewed by a specialist in urology. The model was capable of determining a diagnosis in full (62%) or partial (36%) agreement with the medical report. Agreement between the model and the medical report was excellent (kappa = 0·98, p ? 0·001, CI = 0·88–1) or substantial (kappa = 0·53, p ? 0·001, CI = 0·45–0·60), considering overestimative accordance (where accordance is assumed when at least one diagnosis is equal) and underestimative accordance (where accordance is assumed when all diagnoses are equal), respectively. The proposed model based on the max–min composition of fuzzy relationships is very simple and performed well. However, more tests are recommended before the model is used as a decision support system. 相似文献
9.
Samar AL‐EMADI Mohammed HAMMOUDEH Nagui ABDULWAHAB 《International journal of rheumatic diseases》2007,10(2):156-159
Pyomyositis is a primary infection of the striated muscles. We describe the clinical and imaging features of pyomyositis in two patients, one diabetic and the other immunocompetent. Treatment with incision, drainage and antibiotics was successful and resulted in full recovery. Increased awareness, especially in immuno‐competent patients, should lead to earlier diagnosis, correct treatment and a better outcome. 相似文献