全文获取类型
收费全文 | 10803篇 |
免费 | 1185篇 |
国内免费 | 21篇 |
专业分类
耳鼻咽喉 | 73篇 |
儿科学 | 392篇 |
妇产科学 | 362篇 |
基础医学 | 1545篇 |
口腔科学 | 203篇 |
临床医学 | 1219篇 |
内科学 | 2168篇 |
皮肤病学 | 116篇 |
神经病学 | 799篇 |
特种医学 | 626篇 |
外科学 | 1480篇 |
综合类 | 308篇 |
一般理论 | 7篇 |
预防医学 | 1092篇 |
眼科学 | 107篇 |
药学 | 876篇 |
中国医学 | 3篇 |
肿瘤学 | 633篇 |
出版年
2021年 | 130篇 |
2020年 | 98篇 |
2019年 | 151篇 |
2018年 | 158篇 |
2017年 | 134篇 |
2016年 | 125篇 |
2015年 | 175篇 |
2014年 | 259篇 |
2013年 | 355篇 |
2012年 | 478篇 |
2011年 | 516篇 |
2010年 | 290篇 |
2009年 | 264篇 |
2008年 | 427篇 |
2007年 | 452篇 |
2006年 | 442篇 |
2005年 | 426篇 |
2004年 | 413篇 |
2003年 | 377篇 |
2002年 | 379篇 |
2001年 | 326篇 |
2000年 | 338篇 |
1999年 | 315篇 |
1998年 | 209篇 |
1997年 | 169篇 |
1996年 | 197篇 |
1995年 | 155篇 |
1994年 | 152篇 |
1993年 | 164篇 |
1992年 | 237篇 |
1991年 | 255篇 |
1990年 | 231篇 |
1989年 | 227篇 |
1988年 | 237篇 |
1987年 | 266篇 |
1986年 | 223篇 |
1985年 | 232篇 |
1984年 | 176篇 |
1983年 | 153篇 |
1982年 | 114篇 |
1981年 | 103篇 |
1980年 | 92篇 |
1979年 | 110篇 |
1978年 | 101篇 |
1977年 | 95篇 |
1976年 | 91篇 |
1975年 | 91篇 |
1973年 | 89篇 |
1972年 | 85篇 |
1971年 | 77篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
1.
Charles A. Johnson Jared J. Reid William E. Allen Suvleen K. Singh Josef K. Eichinger Richard J. Friedman 《Seminars in Arthroplasty》2022,32(3):594-599
BackgroundThe purpose of this study is to evaluate the effect of body mass index (BMI) on discharge to a postacute care (PAC) facility following elective total shoulder arthroplasty (TSA).MethodsThe National Surgical Quality Improvement Program database was queried to identify adult patients (>18 years old) who underwent inpatient TSA for primary osteoarthritis between 2005 and 2018. Hemiarthroplasty, revision TSA, trauma indications, and outpatient procedures were excluded. Patient and perioperative data were identified. Univariate analysis and multivariate logistic regression were used to assess the relationship between BMI and discharge to PAC facilities.ResultsA total of 10,198 patients with a primary TSA were identified. The majority (93%) of patients were discharged home vs. 7% to PAC facilities. Patients discharged to PAC had significantly higher mean BMI (P = .006). After controlling for demographic and comorbid factors, BMI was the only modifiable risk factor that was independently associated with an increased risk of discharge to a PAC. For every increase in BMI point, there was an increased risk of discharge to a PAC by 2.9% (odds ratio [OR] 1.029, confidence interval [CI] 1.016-1.041, P < .001). Additional covariates associated with PAC discharge were older age (OR 1.113, CI 1.099-1.127, P < .001), female gender (OR 3.037, CI 2.489-3.705, P < .001), and dependent functional status (OR 8.322, CI 5.544-12.492, P < .001).ConclusionMost patients undergoing TSA were discharged home following surgery. While age, sex, and functional status also affect disposition, elevated BMI is the only modifiable risk factor that independently predicts PAC discharge. Consideration of patient BMI prior to elective TSA may greatly improve discharge planning and management of patient expectations. 相似文献
2.
James I. Geller MD Joseph G. Pressey MD Malcolm A. Smith MD Rachel A. Kudgus PhD Mariana Cajaiba MD Joel M. Reid PhD David Hall PhD Donald A. Barkauskas PhD Stephen D. Voss MD Steve Y. Cho MD Stacey L. Berg MD Jeffrey S. Dome MD PhD Elizabeth Fox MD Brenda J. Weigel MD 《Cancer》2020,126(24):5303-5310
3.
Ki-Yong An Andria R. Morielli Dong-Woo Kang Christine M. Friedenreich Donald C. McKenzie Karen Gelmon John R. Mackey Robert D. Reid Kerry S. Courneya 《International journal of cancer. Journal international du cancer》2020,146(1):150-160
The Combined Aerobic and Resistance Exercise (CARE) Trial compared different types and doses of exercise performed during breast cancer chemotherapy. Here, we report the longer-term follow-up of patient-reported outcomes, health-related fitness and exercise behavior at 6, 12 and 24 months postintervention. A multicenter trial in Canada randomized 301 breast cancer patients initiating chemotherapy to thrice weekly, supervised exercise consisting of a standard dose of 25–30 min of aerobic exercise (STAN; n = 96), a higher dose of 50–60 min of aerobic exercise (HIGH; n = 101) or a combined dose of 50–60 min of aerobic and resistance exercise (COMB; n = 104) performed for the duration of chemotherapy (median of 17 weeks). Primary outcomes were patient-reported outcomes including quality of life, cancer-related symptoms and psychosocial outcomes. Secondary outcomes were objective health-related fitness (assessed at 12 months only) and self-reported exercise behavior. A total of 269 (89.4%) participants completed patient-reported outcomes at all three follow-up time points and 263 (87.4%) completed the health-related fitness assessment at 12-month follow-up. COMB was significantly superior to (i) STAN for sleep quality at 6-month follow-up (p = 0.027); (ii) HIGH for upper body muscular endurance at 12-month follow-up (p = 0.020); and (iii) HIGH for meeting the resistance exercise guideline at 6-month follow-up (p = 0.006). Moreover, self-reported meeting of the combined exercise guideline during follow-up was significantly associated with better patient-reported outcomes and health-related fitness. Performing combined exercise during and after breast cancer chemotherapy may result in better longer-term patient-reported outcomes and health-related fitness compared to performing aerobic exercise alone. 相似文献
4.
Subsequent to a peripheral nerve injury, there are changes in gene expression within the dorsal root ganglia in response to the damage. This review selects factors which are well-known to be vital for inflammation, cell death and nociception, and highlights how alterations in their gene expression within the dorsal root ganglia can affect functional recovery. The majority of studies used polymerase chain reaction within animal models to analyse the dynamic changes following peripheral nerve injuries. This review aims to highlight the factors at the gene expression level that impede functional recovery and are hence are potential targets for therapeutic approaches. Where possible the experimental model, specific time-points and cellular location of expression levels are reported. 相似文献
5.
6.
7.
ABSTRACTGrowing trees on farmland continues to be a promising land-use option for smallholders in Indonesia as they look to diversify their enterprises beyond the main agricultural sector. While most smallholders integrate trees into their farming systems, selling timber and other tree products has usually been infrequent and opportunistic. Because of this infrequent trade, most smallholders rarely adopt silvicultural practices that would increase the commercial value of their trees. A research project trialled an alternative approach to forestry extension in Indonesia, known as the Master TreeGrower (MTG) training course. The MTG training courses used a farmer-centred approach to teach smallholders about forest science and took participants to market hubs so they could better understand how different forest products were valued by traders. The MTG training approach was trialled in 2014 in five districts in Indonesia and involved 118 smallholders and 27 non-farmers as course participants. This article reports on a recent evaluation of the MTG training courses held about three years earlier to explore the enduring impacts of the training approach and whether it can be scaled-out to other areas of Indonesia. The evaluation data were collected via focus group discussions (FGDs), in-depth interviews, household surveys and observations at three project sites: Pati (Central Java), Gunungkidul (Yogyakarta) and Bulukumba (South Sulawesi). A questionnaire was distributed among the participants of the FGDs to assess the extent different knowledge and skills of tree management that had been adopted by them following the MTG courses. The evaluation of the MTG approach revealed that the courses were effective in increasing smallholders’ knowledge of commercial forestry and their silvicultural skills. Many participants were more active with silviculture and planned to invest further in commercial forestry following the MTG training. In effect, the MTG training appeared to change the hearts and minds of the farmers about how commercial forestry could enhance their livelihoods. 相似文献
8.
Béla Nagy Zsolt Bene Zsolt Fejes Sonya L. Heltshe David Reid Nicola J. Ronan Yvonne McCarthy Daniel Smith Attila Nagy Elizabeth Joseloff György Balla János Kappelmayer Milan Macek Scott C. Bell Barry J. Plant Margarida D. Amaral István Balogh 《Journal of cystic fibrosis》2019,18(2):271-277
Background
We have recently shown that human epididymis protein 4 (HE4) levels correlate with the severity of cystic fibrosis (CF) lung disease. However, there are no data on how HE4 levels alter in patients receiving CFTR modulating therapy.Methods
In this retrospective clinical study, 3 independent CF patient cohorts (US-American: 29, Australian: 12 and Irish: 19 cases) were enrolled carrying at least one Class III CFTR CF-causing mutation (p.Gly551Asp) and being treated with CFTR potentiator ivacaftor. Plasma HE4 was measured by immunoassay before treatment (baseline) and 1–6?months after commencement of ivacaftor, and were correlated with FEV1 (% predicted), sweat chloride, C-reactive protein (CRP) and body mass index (BMI).Results
After 1?month of therapy, HE4 levels were significantly lower than at baseline and remained decreased up to 6?months. A significant inverse correlation between absolute and delta values of HE4 and FEV1 (r?=??0.5376; P?<?.001 and r?=??0.3285; P?<?.001), was retrospectively observed in pooled groups, including an independent association of HE4 with FEV1 by multiple regression analysis (β?=??0.57, P?=?.019). Substantial area under the receiver operating characteristic curve (ROC-AUC) value was determined for HE4 when 7% mean change of FEV1 (0.722 [95% CI 0.581–0.863]; P?=?.029) were used as classifier, especially in the first 2?months of treatment (0.806 [95% CI 0.665–0.947]; P?<?.001).Conclusions
This study shows that plasma HE4 levels inversely correlate with lung function improvement in CF patients receiving ivacaftor. Overall, this potential biomarker may be of value for routine clinical and laboratory follow-up of CFTR modulating therapy. 相似文献9.
10.