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Maria Eugenia Olmedo Raquel Cervera Luis Cabezon-Gutierrez Yolanda Lage Elena Corral de la Fuente Ana G mez Rueda Xabier Mielgo-Rubio Juan Carlos Trujillo Felipe Cou ago 《World journal of clinical oncology》2022,13(4):276-286
The 2004 discovery of EGFR mutations, followed by ALK rearrangements, ushered in a targeted therapy era for advanced non-small cell lung cancer (NSCLC). Tyrosine kinase inhibitors targeting gene alterations have substantially improved survival and quality of life for patients with NSCLC. In the last decade, rearrangements of the ROS1 oncogene have been incorporated into healthcare practice that are applicable to another small subgroup of patients who benefit from similar targeted strategies. Recent genome studies of lung adenocarcinoma have identified other possible therapeutic targets, including RET, NTRK fusions, c-MET alterations, and activating mutations in KRAS, BRAF, and HER2, all with frequencies greater than 1%. Lung cancers harbouring these genome changes can potentially be treated with agents approved for other indications or under clinical development. This review updates the therapeutic arsenal that especially targets those genes. 相似文献
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Fernandez-Arroyabe Naiara García-Meléndez Gaspar De Castro-Almeida Ana Raquel Escalona-Perez Francisca Pérez-Lara Almudena González-Quevedo David García-Quevedo David Tamimi Iskandar 《European journal of orthopaedic surgery & traumatology : orthopedie traumatologie》2022,32(7):1371-1377
European Journal of Orthopaedic Surgery & Traumatology - Proton pump inhibitors (PPIs) are one of the most frequently used drugs worldwide. Previous research has shown that they could increase... 相似文献
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Barber Cassandra Burgess Raquel Mountjoy Margo Whyte Rob Vanstone Meredith Grierson Lawrence 《Advances in health sciences education : theory and practice》2022,27(2):475-489
Advances in Health Sciences Education - This study examines the way in which student characteristics and pre-admissions measures are statistically associated with the likelihood a student will... 相似文献
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Daniel Reis Waisberg Edson Abdala Lucas Souto Nacif Luciana Bertocco Haddad Liliana Ducatti Vinicius Rocha Santos Larissa Nunes Gouveia Carolina Santos Lazari Rodrigo Bronze Martino Rafael Soares Pinheiro Rubens Macedo Arantes Debora Raquel Terrabuio Luiz Marcelo Malbouisson Flavio Henrique Galvao Wellington Andraus Luiz Augusto Carneiro‐D'Albuquerque 《Transplant infectious disease》2021,23(1):e13418
The impact of coronavirus disease‐19 (COVID‐19) in liver recipients remains largely unknown. Most data derive from small retrospective series of patients transplanted years ago. We aimed to report a single‐center case series of five consecutive patients in the early postoperative period of deceased‐donor liver transplantation who developed nosocomial COVID‐19. Two patients presented important respiratory discomfort and eventually died. One was 69 years old and had severe coronary disease. She rapidly worsened after COVID‐19 diagnosis on 9th postoperative day. The other was 67 years old with non‐alcoholic steatohepatitis, who experienced prolonged postoperative course, complicated with cytomegalovirus infection and kidney failure. He was diagnosed on 36th postoperative day and remained on mechanical ventilation for 20 days, ultimately succumbing of secondary bacterial infection. The third, fourth, and fifth patients were diagnosed on 10th, 11th, and 18th postoperative day, respectively, and presented satisfactory clinical evolution. These last two patients were severely immunosuppressed, since one underwent steroid bolus for acute cellular rejection and another also used anti‐thymocyte globulin for treating steroid‐resistant rejection. Our novel experience highlights that COVID‐19 may negatively impact the postoperative course, especially in elder and obese patients with comorbidities, and draws attention to COVID‐19 nosocomial spread in the early postoperative period. 相似文献
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Gil-Gouveia Raquel Marques Inês Brás Parreira Elsa Paixão Martins Isabel Pavão Oliveira António Gouveia 《Neurological sciences》2021,42(10):4163-4174
Neurological Sciences - This study aimed to validate a semi-quantitative composite score tool, “Headache Gauge” (HG), to monitor the treatment effect in primary headaches in everyday... 相似文献
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Del Lama Rafael Silva Candido Raquel Mariana Chiari-Correia Natália Santana Nogueira-Barbosa Marcello Henrique de Azevedo-Marques Paulo Mazzoncini Tinós Renato 《Journal of digital imaging》2022,35(3):446-458
Journal of Digital Imaging - Vertebral Compression Fracture (VCF) occurs when the vertebral body partially collapses under the action of compressive forces. Non-traumatic VCFs can be secondary to... 相似文献