全文获取类型
收费全文 | 10094篇 |
免费 | 507篇 |
国内免费 | 22篇 |
专业分类
耳鼻咽喉 | 152篇 |
儿科学 | 283篇 |
妇产科学 | 268篇 |
基础医学 | 1162篇 |
口腔科学 | 230篇 |
临床医学 | 539篇 |
内科学 | 2813篇 |
皮肤病学 | 338篇 |
神经病学 | 702篇 |
特种医学 | 166篇 |
外科学 | 1468篇 |
综合类 | 108篇 |
一般理论 | 1篇 |
预防医学 | 1015篇 |
眼科学 | 183篇 |
药学 | 641篇 |
中国医学 | 65篇 |
肿瘤学 | 489篇 |
出版年
2023年 | 67篇 |
2022年 | 32篇 |
2021年 | 190篇 |
2020年 | 103篇 |
2019年 | 272篇 |
2018年 | 437篇 |
2017年 | 228篇 |
2016年 | 246篇 |
2015年 | 212篇 |
2014年 | 255篇 |
2013年 | 370篇 |
2012年 | 623篇 |
2011年 | 720篇 |
2010年 | 378篇 |
2009年 | 248篇 |
2008年 | 600篇 |
2007年 | 606篇 |
2006年 | 682篇 |
2005年 | 636篇 |
2004年 | 581篇 |
2003年 | 550篇 |
2002年 | 494篇 |
2001年 | 356篇 |
2000年 | 439篇 |
1999年 | 308篇 |
1998年 | 45篇 |
1997年 | 35篇 |
1996年 | 23篇 |
1995年 | 16篇 |
1994年 | 22篇 |
1993年 | 22篇 |
1992年 | 101篇 |
1991年 | 85篇 |
1990年 | 93篇 |
1989年 | 65篇 |
1988年 | 54篇 |
1987年 | 59篇 |
1986年 | 60篇 |
1985年 | 43篇 |
1984年 | 24篇 |
1983年 | 24篇 |
1980年 | 13篇 |
1979年 | 14篇 |
1978年 | 15篇 |
1976年 | 13篇 |
1974年 | 13篇 |
1973年 | 15篇 |
1971年 | 18篇 |
1970年 | 12篇 |
1969年 | 17篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
1.
Antonio Montalvo Afonso Fernando Ruiz Juretschke Rosario González Rodrigálvarez Olga Mateo Sierra Begoña Iza Vallejo Roberto García Leal Marc Valera Melé Vicente Casitas Hernando Jose Manuel Hernández Poveda Carlos Fernández Carballal 《Neurocirugía (Asturias, Spain)》2021,32(1):1-9
Background and objectivesThe treatment of deafferentation pain by spinal DREZotomy is a proven therapeutic option in the literature. In recent years, use of DREZotomy has been relegated to second place due to the emergence of neuromodulation therapies. The objectives of this study are to demonstrate that DREZotomy continues to be an effective and safe treatment and to analyse predictive factors for success.Patients and methodsA retrospective study was conducted of all patients treated in our department with spinal DREZotomy from 1998 to 2018. Bulbar DREZotomy procedures were excluded. A visual analogue scale (VAS) and the reduction of routine medication were used as outcome variables. Demographic, clinical and operative variables were analysed as predictive factors for success.ResultsA total of 27 patients (51.9% female) with a mean age of 53.7 years underwent DREZotomy. The main cause of pain was brachial plexus injury (BPI) (55.6%) followed by neoplasms (18.5%). The mean time of pain evolution was 8.4 years with a mean intensity of 8.7 according to the VAS, even though 63% of the patients had previously received neurostimulation therapy. Favourable outcome (≥ 50% pain reduction in the VAS) was observed in 77.8% of patients during the postoperative period and remained in 59.3% of patients after 22 months average follow-up (mean reduction of 4.9 points). This allowed for a reduction in routine analgesic treatment in 70.4% of them. DREZotomy in BPI-related pain presented a significantly higher success rate (93%) than the other pathologies (41.7%) (p = .001). No association was observed between outcome and age, gender, DREZ technique, duration of pain or previous neurostimulation therapies. There were six neurological complications, four post-operative transient neurological deficits and two permanent deficits.ConclusionDorsal root entry zone surgery is effective and safe for treating patients with deafferentation pain, especially after brachial plexus injury. It can be considered an alternative treatment after failed neurostimulation techniques for pain control. However, its indication should be considered as the first therapeutic option after medical therapy failure due to its good long-term results. 相似文献
2.
Sandra Pérez Andrea Masegoso Nazaret Hernández-Espeso 《Clinical psychology & psychotherapy》2021,28(3):606-614
Due to the COVID-19 pandemic's consequences and the state of alarm, literature has shown that people worldwide have experienced severe stressors that have been associated with increased prevalence of emotional distress. In this study, we explored psychological distress (depression, anxiety, and somatization symptoms) using an online survey platform in a sample of 1,781 Spanish adults during the confinement due to COVID-19, relationships between distress and sleep problems, affect, pain, sleep, emotional regulation, gender, type of housing, history of psychopathology, and living alone during the confinement, and differences depending on demographic and psychological variables. Results showed that between 25% and 39% of the sample referred to clinically significant levels of distress. In addition, women showed higher levels of distress, negative affect, perception of pain, and cognitive reappraisal and lower levels of emotional suppression and sleep quality than men. A history of psychopathology, being younger, living alone or in a flat was associated with higher distress. Finally, the variables most strongly related to distress were negative and positive affect, levels of pain, sleep quality, and emotional suppression. Our results highlight the important role of emotional suppression, cognitive reappraisal, and loneliness and the impact of being a woman and younger in Spain during the COVID-19 pandemic. Therefore, it would be necessary to provide assessments of distress levels in these population groups and focus psychological preventive and therapeutic online interventions on expressing emotions and preventing loneliness. 相似文献
3.
Sonia Moreno-Grau Itziar de Rojas Isabel Hernández Inés Quintela Laura Montrreal Montserrat Alegret Begoña Hernández-Olasagarre Laura Madrid Antonio González-Perez Olalla Maroñas Maitée Rosende-Roca Ana Mauleón Liliana Vargas Asunción Lafuente Carla Abdelnour Octavio Rodríguez-Gómez Silvia Gil Miguel Ángel Santos-Santos Agustín Ruiz 《Alzheimer's & dementia》2019,15(10):1333-1347
IntroductionLarge variability among Alzheimer's disease (AD) cases might impact genetic discoveries and complicate dissection of underlying biological pathways.MethodsGenome Research at Fundacio ACE ([email protected]) is a genome-wide study of dementia and its clinical endophenotypes, defined based on AD's clinical certainty and vascular burden. We assessed the impact of known AD loci across endophenotypes to generate loci categories. We incorporated gene coexpression data and conducted pathway analysis per category. Finally, to evaluate the effect of heterogeneity in genetic studies, [email protected] series were meta-analyzed with additional genome-wide association study data sets.ResultsWe classified known AD loci into three categories, which might reflect the disease clinical heterogeneity. Vascular processes were only detected as a causal mechanism in probable AD. The meta-analysis strategy revealed the ANKRD31-rs4704171 and NDUFAF6-rs10098778 and confirmed SCIMP-rs7225151 and CD33-rs3865444.DiscussionThe regulation of vasculature is a prominent causal component of probable AD. [email protected] meta-analysis revealed novel AD genetic signals, strongly driven by the presence of clinical heterogeneity in the AD series. 相似文献
4.
J. Caño-Velasco F. Herranz-Amo G. Barbas-Bernardos L. Polanco-Pujol E. Lledó-García C. Hernández-Fernández 《Actas urologicas espa?olas》2019,43(1):18-25
Introduction and objectives
The onset of second primary tumours should be considered in high-risk prostate cancer patients in the natural course of the disease. Our aim was to evaluate the influence of primary treatment with curative intent for these patients on the development of second primary tumours.Material and methods
A retrospective study of 286 patients diagnosed between 1996 and 2008, treated by radical prostatectomy (n = 145) or radiotherapy and androgen blockade (n = 141). The homogeneity of both series was analysed using the Chi-squared test for the qualitative variables, and the Student's t-test for the quantitative variables. A multivariate Cox regression analysis was performed to assess whether the type of primary treatment influenced the development of second tumours.Results
The median age was 66 years, and the median follow-up was 117.5 months. At the end of follow-up, 60 patients (21%) had developed a second primary tumour. In the prostatectomy group it was located in the pelvis in 13 (9%) cases, and those treated with radiotherapy and hormonotherapy in 8 (5.7%) cases (P = .29). The most common organ sites were: colo-rectal in 17 (28.3%) patients, the lung in 11 (18.3%), and the bladder in 6 (10%) patients. In the multivariable analysis, the risk of a second tumour doubled for those treated with radiotherapy and hormonotherapy (HR = 2.41, 95%CI: 1.31-4.34, P = .005) compared to the patients treated by prostatectomy. Age and rescue radiotherapy did not behave as independent predictive factors.Conclusions
The onset of a second primary tumour was related with the primary treatment given; thus the risk for those treated with radiotherapy and androgen deprivation therapy more than doubled. 相似文献5.
6.
David E. Barajas-Galindo Alfonso Vidal-Casariego Emilia Gómez-Hoyos Paula Fernández-Martínez María Guerra González Ana Hernández-Moreno Miran Alejo-Ramos Rocío Villar-Taibo Isidoro Cano-Rodríguez María D. Ballesteros-Pomar 《Nefrología : publicación oficial de la Sociedad Espa?ola Nefrologia》2019,39(6):672-674
7.
8.
9.
Juan-Carlos Hernández-Boluda Eduardo Arellano-Rodrigo Francisco Cervantes Alberto Alvarez-Larrán Montse Gómez Pere Barba María-Isabel Mata José-Ramón González-Porras Francisca Ferrer-Marín Valentín García-Gutiérrez Elena Magro Melania Moreno Ana Kerguelen Manuel Pérez-Encinas Natàlia Estrada Rosa Ayala Carles Besses Arturo Pereira 《Annals of hematology》2015,94(6):911-918