全文获取类型
收费全文 | 10023篇 |
免费 | 797篇 |
国内免费 | 41篇 |
专业分类
耳鼻咽喉 | 42篇 |
儿科学 | 276篇 |
妇产科学 | 208篇 |
基础医学 | 1848篇 |
口腔科学 | 85篇 |
临床医学 | 979篇 |
内科学 | 2159篇 |
皮肤病学 | 228篇 |
神经病学 | 1110篇 |
特种医学 | 260篇 |
外科学 | 1115篇 |
综合类 | 26篇 |
一般理论 | 2篇 |
预防医学 | 795篇 |
眼科学 | 113篇 |
药学 | 687篇 |
中国医学 | 6篇 |
肿瘤学 | 922篇 |
出版年
2023年 | 89篇 |
2022年 | 51篇 |
2021年 | 275篇 |
2020年 | 175篇 |
2019年 | 226篇 |
2018年 | 321篇 |
2017年 | 191篇 |
2016年 | 253篇 |
2015年 | 302篇 |
2014年 | 421篇 |
2013年 | 529篇 |
2012年 | 821篇 |
2011年 | 816篇 |
2010年 | 417篇 |
2009年 | 437篇 |
2008年 | 668篇 |
2007年 | 694篇 |
2006年 | 643篇 |
2005年 | 713篇 |
2004年 | 556篇 |
2003年 | 558篇 |
2002年 | 469篇 |
2001年 | 108篇 |
2000年 | 81篇 |
1999年 | 97篇 |
1998年 | 91篇 |
1997年 | 68篇 |
1996年 | 48篇 |
1995年 | 58篇 |
1994年 | 39篇 |
1993年 | 37篇 |
1992年 | 46篇 |
1991年 | 45篇 |
1990年 | 41篇 |
1989年 | 33篇 |
1988年 | 34篇 |
1987年 | 29篇 |
1986年 | 32篇 |
1985年 | 21篇 |
1984年 | 21篇 |
1983年 | 18篇 |
1980年 | 14篇 |
1979年 | 14篇 |
1978年 | 12篇 |
1977年 | 13篇 |
1974年 | 17篇 |
1973年 | 19篇 |
1971年 | 18篇 |
1970年 | 12篇 |
1927年 | 11篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Li Dong Mari Nygård Nathalie C. Støer Ole Klungsøyr Bo T. Hansen 《International journal of cancer. Journal international du cancer》2023,153(2):399-406
Human papillomavirus (HPV) vaccine effectiveness may differ between settings. Here we present the first real-world effectiveness study of HPV vaccination on high-grade cervical lesions from Norway, among women who received HPV vaccine outside the routine program. We performed an observational study of all Norwegian women born 1975 to 1996 and retrieved individual data from nationwide registries on HPV vaccination status and incidence of histologically verified high-grade cervical neoplasia during 2006 to 2016. We estimated the incidence rate ratio (IRR) and 95% confidence intervals (CI) for vaccination vs no vaccination by Poisson regression stratified by age at vaccination <20 years and ≥20 years. The cohort consisted of 832 732 women, of which 46 381 (5.6%) received at least one dose of HPV vaccine by the end of 2016. The incidence rate of cervical intraepithelial neoplasia grade 2 or worse (CIN2+) increased with age regardless of vaccination status and was highest at age 25 to 29, at 637/100 000 among unvaccinated women, 487/100 000 among women vaccinated before age 20 and 831/100 000 among women vaccinated at age 20 or older. The adjusted IRR of CIN2+ between vaccinated and unvaccinated women was 0.62 (95% CI: 0.46-0.84) for women vaccinated below age 20, and 1.22 (95% CI: 1.03-1.43) for women vaccinated at age 20 or older. These findings indicate that HPV vaccination among women too old to be eligible for routine HPV vaccination is effective among women who are vaccinated below age 20 but may not have the desired impact among women who are vaccinated at age 20 or older. 相似文献
2.
Kayla Ann Andrews Joel S. Owen James McCarthy David Wesche Nathalie Gobeau Thaddeus H. Grasela Jrg J. Mhrle 《CTS Clinical and Translational Science》2021,14(2):712
Volunteer infection studies using the induced blood stage malaria (IBSM) model have been shown to facilitate antimalarial drug development. Such studies have traditionally been undertaken in single‐dose cohorts, as many as necessary to obtain the dose‐response relationship. To enhance ethical and logistic aspects of such studies, and to reduce the number of cohorts needed to establish the dose‐response relationship, we undertook a retrospective in silico analysis of previously accrued data to improve study design. A pharmacokinetic (PK)/pharmacodynamic (PD) model was developed from initial fictive‐cohort data for OZ439 (mixing the data of the three single‐dose cohorts as: n = 2 on 100 mg, 2 on 200 mg, and 4 on 500 mg). A three‐compartment model described OZ439 PKs. Net growth of parasites was modeled using a Gompertz function and drug‐induced parasite death using a Hill function. Parameter estimates for the PK and PD models were comparable for the multidose single‐cohort vs. the pooled analysis of all cohorts. Simulations based on the multidose single‐cohort design described the complete data from the original IBSM study. The novel design allows for the ascertainment of the PK/PD relationship early in the study, providing a basis for rational dose selection for subsequent cohorts and studies. Study Highlights
- WHAT IS THE CURRENT KNOWLEDGE ON THE TOPIC?
- WHAT QUESTION DID THIS STUDY ADDRESS?
- WHAT DOES THIS STUDY ADD TO OUR KNOWLEDGE?
- HOW MIGHT THIS CHANGE CLINICAL PHARMACOLOGY OR TRANSLATIONAL SCIENCE?
3.
4.
5.
6.
7.
Peter Manser Daniel Frauchiger Daniel Frei Werner Volken Dario Terribilini Michael K. Fix 《Zeitschrift für medizinische Physik》2019,29(1):31-38
Purpose
Using volumetric modulated arc therapy (VMAT) delivery technique gantry position, multi-leaf collimator (MLC) as well as dose rate change dynamically during the application. However, additional components can be dynamically altered throughout the dose delivery such as the collimator or the couch. Thus, the degrees of freedom increase allowing almost arbitrary dynamic trajectories for the beam. While the dose delivery of such dynamic trajectories for linear accelerators is technically possible, there is currently no dose calculation and validation tool available. Thus, the aim of this work is to develop a dose calculation and verification tool for dynamic trajectories using Monte Carlo (MC) methods.Methods
The dose calculation for dynamic trajectories is implemented in the previously developed Swiss Monte Carlo Plan (SMCP). SMCP interfaces the treatment planning system Eclipse with a MC dose calculation algorithm and is already able to handle dynamic MLC and gantry rotations. Hence, the additional dynamic components, namely the collimator and the couch, are described similarly to the dynamic MLC by defining data pairs of positions of the dynamic component and the corresponding MU-fractions. For validation purposes, measurements are performed with the Delta4 phantom and film measurements using the developer mode on a TrueBeam linear accelerator. These measured dose distributions are then compared with the corresponding calculations using SMCP. First, simple academic cases applying one-dimensional movements are investigated and second, more complex dynamic trajectories with several simultaneously moving components are compared considering academic cases as well as a clinically motivated prostate case.Results
The dose calculation for dynamic trajectories is successfully implemented into SMCP. The comparisons between the measured and calculated dose distributions for the simple as well as for the more complex situations show an agreement which is generally within 3% of the maximum dose or 3 mm. The required computation time for the dose calculation remains the same when the additional dynamic moving components are included.Conclusion
The results obtained for the dose comparisons for simple and complex situations suggest that the extended SMCP is an accurate dose calculation and efficient verification tool for dynamic trajectory radiotherapy. This work was supported by Varian Medical Systems. 相似文献8.
9.
10.