全文获取类型
收费全文 | 269112篇 |
免费 | 12836篇 |
国内免费 | 907篇 |
专业分类
耳鼻咽喉 | 3165篇 |
儿科学 | 8301篇 |
妇产科学 | 6458篇 |
基础医学 | 38676篇 |
口腔科学 | 8681篇 |
临床医学 | 19288篇 |
内科学 | 59212篇 |
皮肤病学 | 7220篇 |
神经病学 | 23915篇 |
特种医学 | 6614篇 |
外国民族医学 | 2篇 |
外科学 | 28422篇 |
综合类 | 1204篇 |
一般理论 | 80篇 |
预防医学 | 29936篇 |
眼科学 | 6097篇 |
药学 | 20300篇 |
1篇 | |
中国医学 | 1023篇 |
肿瘤学 | 14260篇 |
出版年
2023年 | 1782篇 |
2022年 | 1360篇 |
2021年 | 5251篇 |
2020年 | 3744篇 |
2019年 | 6013篇 |
2018年 | 8511篇 |
2017年 | 5789篇 |
2016年 | 6087篇 |
2015年 | 6792篇 |
2014年 | 8312篇 |
2013年 | 11749篇 |
2012年 | 19013篇 |
2011年 | 19888篇 |
2010年 | 10306篇 |
2009年 | 8180篇 |
2008年 | 16076篇 |
2007年 | 16728篇 |
2006年 | 15748篇 |
2005年 | 14958篇 |
2004年 | 13743篇 |
2003年 | 12717篇 |
2002年 | 11687篇 |
2001年 | 5467篇 |
2000年 | 5835篇 |
1999年 | 4721篇 |
1998年 | 1362篇 |
1997年 | 991篇 |
1995年 | 890篇 |
1992年 | 2529篇 |
1991年 | 2206篇 |
1990年 | 2214篇 |
1989年 | 1897篇 |
1988年 | 1806篇 |
1987年 | 1682篇 |
1986年 | 1722篇 |
1985年 | 1588篇 |
1984年 | 1185篇 |
1983年 | 1040篇 |
1979年 | 1292篇 |
1978年 | 905篇 |
1975年 | 931篇 |
1974年 | 1180篇 |
1973年 | 1215篇 |
1972年 | 1151篇 |
1971年 | 1109篇 |
1970年 | 1032篇 |
1969年 | 1107篇 |
1968年 | 1121篇 |
1967年 | 1001篇 |
1966年 | 897篇 |
排序方式: 共有10000条查询结果,搜索用时 16 毫秒
1.
2.
3.
Sirufo Maria Maddalena Magnanimi Lina Maria Ginaldi Lia De Martinis Massimo 《Clinical rheumatology》2022,41(12):3921-3922
Clinical Rheumatology - 相似文献
4.
The coronavirus disease 2019 (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Hepatic involvement is common in SARS-CoV-2-infected individuals. It is currently accepted that the direct and indirect hepatic effects of SARS-CoV-2 infection play a significant role in COVID-19. In individuals with pre-existing infectious and non-infectious liver disease, who are at a remarkably higher risk of developing severe COVID-19 and death, this pathology is most medically relevant. This review emphasizes the current pathways regarded as contributing to the gastrointestinal and hepatic ailments linked to COVID-19-infected patients due to an imbalanced interaction among the liver, systemic inflammation, disrupted coagulation, and the lung. 相似文献
5.
Karhanová Marta Kalitová Jana Kovář Radim Schovánek Jan Karásek David Čivrný Jakub Hübnerová Petra Mlčák Petr Šín Martin 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2022,260(12):3977-3984
Graefe's Archive for Clinical and Experimental Ophthalmology - The purpose was to ascertain if any relation exists between the elevated intraocular pressure (IOP) in patients with... 相似文献
6.
European Journal of Epidemiology - With the rising use of machine learning for healthcare applications, practitioners are increasingly confronted with the limitations of prediction models that are... 相似文献
7.
Abou-Dakn Michael Alexy Ute Beyer Kirsten Cremer Monika Ensenauer Regina Flothkötter Maria Geene Raimund Hellmers Claudia Joisten Christine Koletzko Berthold Mata Jutta Schiffner Ulrich Somm Irene Speck Melanie Weißenborn Anke Wöckel Achim 《Monatsschrift für Kinderheilkunde》2022,170(10):925-928
Monatsschrift Kinderheilkunde - 相似文献
8.
Silvia Radenkovic Diego Martinelli Yuebo Zhang Graeme J. Preston Arianna Maiorana Alessandra Terracciano Maria Lisa Dentici Elisa Pisaneschi Antonio Novelli Wasantha Ranatunga Anna N. Ligezka Bart Ghesquière David R. Deyle Tamas Kozicz Filippo Pinto e Vairo Peter Witters Eva Morava 《Genetics in medicine》2022,24(4):894-904
PurposeTRAPPC9 deficiency is an autosomal recessive disorder mainly associated with intellectual disability (ID), microcephaly, and obesity. Previously, TRAPPC9 deficiency has not been associated with biochemical abnormalities.MethodsExome sequencing was performed in 3 individuals with ID and dysmorphic features. N-Glycosylation analyses were performed in the patients’ blood samples to test for possible congenital disorder of glycosylation (CDG). TRAPPC9 gene, TRAPPC9 protein expression, and N-glycosylation markers were assessed in patient fibroblasts. Complementation with wild-type TRAPPC9 and immunofluorescence studies to assess TRAPPC9 expression and localization were performed. The metabolic consequences of TRAPPC9 deficiency were evaluated using tracer metabolomics.ResultsAll 3 patients carried biallelic missense variants in TRAPPC9 and presented with an N-glycosylation defect in blood, consistent with CDG type I. Extensive investigations in patient fibroblasts corroborated TRAPPC9 deficiency and an N-glycosylation defect. Tracer metabolomics revealed global metabolic changes with several affected glycosylation-related metabolites.ConclusionWe identified 3 TRAPPC9 deficient patients presenting with ID, dysmorphic features, and abnormal glycosylation. On the basis of our findings, we propose that TRAPPC9 deficiency could lead to a CDG (TRAPPC9-CDG). The finding of abnormal glycosylation in these patients is highly relevant for diagnosis, further elucidation of the pathophysiology, and management of the disease. 相似文献
9.
Sánchez Restrepo Frank Hernández Valdivieso Alher Mauricio 《Journal of pharmacokinetics and pharmacodynamics》2022,49(4):411-428
Journal of Pharmacokinetics and Pharmacodynamics - The integration between physiologically-based pharmacokinetics (PBPK) models and pharmacodynamics (PD) models makes it possible to describe the... 相似文献
10.
Paula Pessin Fábrega Branisso Claudia Pinto Marques Souza de Oliveira Hilton Muniz Leão Filho Fabiana Roberto Lima Aritânia Sousa Santos Marcio Correa Mancini Maria Edna de Melo Flair José Carrilho Manoel de Souza Rocha Paul Clark Henrique José Pereira Branisso Cintia Cercato 《Annals of hepatology》2022,27(4):100707
IntroductionAlthough hyperferritinemia may reflect the inflammatory status of patients with non-alcoholic fatty liver disease (NAFLD), approximately 33% of hyperferritinemia cases reflect real hepatic iron overload.AimTo evaluate a non-invasive method for assessing mild iron overload in patients with NAFLD using 3T magnetic resonance imaging (MRI) relaxometry, serum hepcidin, and the expression of ferritin subunits.MethodsThis cross-sectional study assessed patients with biopsy-proven NAFLD. MRI relaxometry was performed using a 3T scanner in all patients, and the results were compared with iron content determined by liver biopsy. Ferritin, hepcidin, and ferritin subunits were assessed and classified according to ferritin levels and to siderosis identified by liver biopsy.ResultsA total of 67 patients with NAFLD were included in the study. MRI revealed mild iron overload in all patients (sensitivity, 73.5%; specificity, 70%). For mild (grade 1) siderosis, the transverse relaxation rate (R2*) threshold was 58.9 s?1 and the mean value was 72.5 s?1 (SD, 33.9), while for grades 2/3 it was 88.2 s?1 (SD, 31.9) (p < 0.001). The hepcidin threshold for siderosis was > 30.2 ng/mL (sensitivity, 87%; specificity, 82%). Ferritin H and ferritin L subunits were expressed similarly in patients with NAFLD, regardless of siderosis. There were no significant differences in laboratory test results between the groups, including glucose parameters and liver function tests.ConclusionsMRI relaxometry and serum hepcidin accurately assessed mild iron overload in patients with dysmetabolic iron overload syndrome. 相似文献