全文获取类型
收费全文 | 103082篇 |
免费 | 6117篇 |
国内免费 | 572篇 |
专业分类
耳鼻咽喉 | 1022篇 |
儿科学 | 3417篇 |
妇产科学 | 2440篇 |
基础医学 | 14924篇 |
口腔科学 | 3868篇 |
临床医学 | 9292篇 |
内科学 | 22757篇 |
皮肤病学 | 2688篇 |
神经病学 | 10232篇 |
特种医学 | 2428篇 |
外国民族医学 | 1篇 |
外科学 | 9342篇 |
综合类 | 387篇 |
一般理论 | 48篇 |
预防医学 | 10124篇 |
眼科学 | 1687篇 |
药学 | 7362篇 |
中国医学 | 408篇 |
肿瘤学 | 7344篇 |
出版年
2023年 | 949篇 |
2022年 | 810篇 |
2021年 | 2633篇 |
2020年 | 2240篇 |
2019年 | 2998篇 |
2018年 | 3444篇 |
2017年 | 2654篇 |
2016年 | 3003篇 |
2015年 | 3381篇 |
2014年 | 4475篇 |
2013年 | 5843篇 |
2012年 | 8907篇 |
2011年 | 9270篇 |
2010年 | 5040篇 |
2009年 | 4245篇 |
2008年 | 7365篇 |
2007年 | 7354篇 |
2006年 | 6766篇 |
2005年 | 6305篇 |
2004年 | 5666篇 |
2003年 | 5042篇 |
2002年 | 4518篇 |
2001年 | 520篇 |
2000年 | 347篇 |
1999年 | 518篇 |
1998年 | 605篇 |
1997年 | 505篇 |
1996年 | 413篇 |
1995年 | 447篇 |
1994年 | 422篇 |
1993年 | 349篇 |
1992年 | 277篇 |
1991年 | 187篇 |
1990年 | 192篇 |
1989年 | 176篇 |
1988年 | 169篇 |
1987年 | 140篇 |
1986年 | 154篇 |
1985年 | 109篇 |
1984年 | 129篇 |
1983年 | 124篇 |
1982年 | 152篇 |
1981年 | 111篇 |
1980年 | 122篇 |
1979年 | 71篇 |
1978年 | 75篇 |
1977年 | 67篇 |
1976年 | 56篇 |
1975年 | 45篇 |
1974年 | 52篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Rizzo Giuseppe Pietrolucci Maria Elena Capponi Alessandra Mappa Ilenia 《The international journal of cardiovascular imaging》2022,38(5):1017-1019
The International Journal of Cardiovascular Imaging - 相似文献
2.
Clinical Autonomic Research - 相似文献
3.
Alterio Daniela La Rocca Eliana Volpe Stefania Camarda Anna Maria Casbarra Alessia Russell-Edu William Zerella Maria Alessia Orecchia Roberto Galimberti Viviana Veronesi Paolo Leonardi Maria Cristina Jereczek-Fossa Barbara Alicja 《Breast cancer research and treatment》2022,192(2):249-263
Breast Cancer Research and Treatment - To critically review available literature on hypofractionated (≥?3 Gy/fraction) proton therapy (PT) for breast cancer (BCa). A systematic... 相似文献
4.
Merzenich Hiltrud Baaken Dan Schmidt Marcus Bekes Inga Schwentner Lukas Janni Wolfgang Woeckel Achim Bartkowiak Detlef Wiegel Thomas Blettner Maria Wollschläger Daniel Schmidberger Heinz 《Breast cancer research and treatment》2022,191(1):147-157
Breast Cancer Research and Treatment - Radiotherapy (RT) was identified as a risk factor for long-term cardiac effects in breast cancer patients treated until the 1990s. However, modern techniques... 相似文献
5.
Anna Maria Spera 《World Journal of Virology》2022,11(5):275-282
With a 5.3% of the global population involved, hepatitis B virus (HBV) is a major public health challenge requiring an urgent response. After a possible acute phase, the natural history of HBV infection can progress in chronicity. Patients with overt or occult HBV infection can undergo HBV reactivation (HBVr) in course of immunosuppressive treatments that, apart from oncological and hem-atological diseases, are also used in rheumatologic, gastrointestinal, neurological and dermatological settings, as well as to treat severe acute respiratory syndrome coronavirus 2 infection. The risk of HBV reactivation is related to the immune status of the patient and the baseline HBV infection condition. The aim of the present paper is to investigate the risk of HBVr in those not oncological settings in order to suggest strategies for preventing and treating this occurrence. The main studies about HBVr for patients with occult hepatitis B infection and chronic HBV infection affected by non-oncologic diseases eligible for immunosuppressive treatment have been analyzed. The occurrence of this challenging event can be reduced screening the population eligible for immunosuppressant to assess the best strategies according to any virological status. Further prospective studies are needed to increase data on the risk of HBVr related to newer immunomodulant agents employed in non-oncological setting. 相似文献
6.
Simone Oerlemans PhD Fabio Efficace PhD Charalampia Kyriakou PhD MD Ana Carolina Freitas PhD MD Omar Shamieh PhD MD Carien L. Creutzberg PhD MD Jens Lehmann PhD Duska Petranovic PhD MD Eva Nagele PhD Anne Bredart PhD Dong Dong PhD Christian W. Scholz PhD MD Giovanni Caocci PhD MD Stefano Molica PhD MD Laimonas Griskevicius PhD MD Aliki Xochelli PhD MD Jacobien M. Kieffer PhD Joost A. Agelink van Rentergem PhD Waleed Alrjoub BSN Anja Mueller PhD Maria Gomes Da Silva PhD MD Filipa Alves da Costa PhD PharmD Sandra Malak PhD MD Kim Cocks PhD Lonneke V. van de Poll-Franse PhD the EORTC Quality of Life Group 《Cancer》2023,129(17):2727-2740
Background
Health-related quality of life (HRQOL) is a critical aspect to consider when making treatment decisions for patients with non-Hodgkin-lymphoma (NHL). This international study by the European Organisation for Research and Treatment of Cancer (EORTC) tested the psychometric properties of two newly developed measures for patients with high-grade (HG)- and low-grade (LG)-NHL: the EORTC QLQ-NHL-HG29 and the EORTC QLQ-NHL-LG20 to supplement the core questionnaire (EORTC QLQ-C30).Methods
Overall, 768 patients with HG-NHL (N = 423) and LG-NHL (N = 345) from 12 countries completed the QLQ-C30, QLQ-NHL-HG29/QLQ-NHL-LG20 and a debriefing questionnaire at baseline, and a subset at follow-up for either retest (N = 125/124) or responsiveness to change (RCA; N = 98/49).Results
Confirmatory factor analysis showed an acceptable to good fit of the 29 items of the QLQ-NHL-HG29 on its five scales (symptom burden [SB], neuropathy, physical condition/fatigue [PF], emotional impact [EI], and worries about health/functioning [WH]), and of the 20 items of the QLQ-NHL-LG20 on its four scales (SB, PF, EI, and WH). Completion took on average 10 minutes. Test–retest reliability, convergent validity, known-group comparisons, and RCA find satisfactory results of both measures. A total of 31%–78% of patients with HG-NHL and 22%–73% of patients with LG-NHL reported symptoms and/or worries (e.g., tingling in hands/feet, lack of energy, and worries about recurrence). Patients reporting symptoms/worries had substantially lower HRQOL compared to those without.Discussion
The use of the EORTC QLQ-NHL-HG29 and QLQ-NHL-LG20 questionnaires in clinical research and practice will provide clinically relevant data to better inform treatment decision-making.Plain language summary
- The European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group developed two questionnaires.
- These questionnaires measure health-related quality of life.
- The questionnaires are for patients with high-grade or low-grade non-Hodgkin lymphoma.
- They are called the EORTC QLQ-NHL-HG29 and QLQ-NHL-LG20.
- The questionnaires are now internationally validated.
- This study demonstrates that the questionnaires are reliably and valid, which are important aspects of a questionnaire.
- The questionnaires can now be used in clinical trials and practice.
- With the information gathered from the questionnaires, patients and clinicians can better evaluate treatments and discuss the best choice for a patient.
7.
Thomas Behrens Calvin Ge Roel Vermeulen Benjamin Kendzia Ann Olsson Joachim Schüz Hans Kromhout Beate Pesch Susan Peters Lützen Portengen Per Gustavsson Dario Mirabelli Pascal Guénel Danièle Luce Dario Consonni Neil E. Caporaso Maria Teresa Landi John K. Field Stefan Karrasch Heinz-Erich Wichmann Jack Siemiatycki Marie-Elise Parent Lorenzo Richiardi Lorenzo Simonato Karl-Heinz Jöckel Wolfgang Ahrens Hermann Pohlabeln Guillermo Fernández-Tardón David Zaridze John R. McLaughlin Paul A. Demers Beata Świątkowska Jolanta Lissowska Tamás Pándics Eleonora Fabianova Dana Mates Vladimir Bencko Lenka Foretova Vladimír Janout Paolo Boffetta Bas Bueno-de-Mesquita Francesco Forastiere Kurt Straif Thomas Brüning 《International journal of cancer. Journal international du cancer》2023,152(4):645-660
There is limited evidence regarding the exposure-effect relationship between lung-cancer risk and hexavalent chromium (Cr(VI)) or nickel. We estimated lung-cancer risks in relation to quantitative indices of occupational exposure to Cr(VI) and nickel and their interaction with smoking habits. We pooled 14 case-control studies from Europe and Canada, including 16 901 lung-cancer cases and 20 965 control subjects. A measurement-based job-exposure-matrix estimated job-year-region specific exposure levels to Cr(VI) and nickel, which were linked to the subjects' occupational histories. Odds ratios (OR) and associated 95% confidence intervals (CI) were calculated by unconditional logistic regression, adjusting for study, age group, smoking habits and exposure to other occupational lung carcinogens. Due to their high correlation, we refrained from mutually adjusting for Cr(VI) and nickel independently. In men, ORs for the highest quartile of cumulative exposure to CR(VI) were 1.32 (95% CI 1.19-1.47) and 1.29 (95% CI 1.15-1.45) in relation to nickel. Analogous results among women were: 1.04 (95% CI 0.48-2.24) and 1.29 (95% CI 0.60-2.86), respectively. In men, excess lung-cancer risks due to occupational Cr(VI) and nickel exposure were also observed in each stratum of never, former and current smokers. Joint effects of Cr(VI) and nickel with smoking were in general greater than additive, but not different from multiplicative. In summary, relatively low cumulative levels of occupational exposure to Cr(VI) and nickel were associated with increased ORs for lung cancer, particularly in men. However, we cannot rule out a combined classical measurement and Berkson-type of error structure, which may cause differential bias of risk estimates. 相似文献
8.
Nicla La Verde Agostino Riva Maria Silvia Cona Arianna Gabrieli Monica Cattaneo Cinzia Fasola Giuseppe Lipari Claudia De Stradis Valentina Favorito Benedetta Lombardi Stocchetti Davide Chizzoniti Alice Covizzi Eliana Rulli Francesca Galli Lorenzo Ruggieri Anna Gambaro Sabrina Ferrario Davide Dalu Maciej S. Tarkowski 《International journal of cancer. Journal international du cancer》2023,152(4):661-671
Previous studies on the immunogenicity of SARS-CoV-2 mRNA vaccines showed a reduced seroconversion in cancer patients. The aim of our study is to evaluate the immunogenicity of two doses of mRNA vaccines in solid cancer patients with or without a previous exposure to the virus. This is a single-institution, prospective, nonrandomized study. Patients in active treatment and a control cohort of healthy people received two doses of BNT162b2 (Comirnaty, BioNTech/Pfizer, The United States) or mRNA-1273 (Spikevax, Moderna). Vaccine was administered before starting anticancer therapy or on the first day of the treatment cycle. SARS-CoV-2 antibody levels against S1, RBD (to evaluate vaccine response) and N proteins (to evaluate previous infection) were measured in plasma before the first dose and 30 days after the second one. From January to June 2021, 195 consecutive cancer patients and 20 healthy controls were enrolled. Thirty-one cancer patients had a previous exposure to SARS-CoV-2. Cancer patients previously exposed to the virus had significantly higher median levels of anti-S1 and anti-RBD IgG, compared to healthy controls (P = .0349) and to cancer patients without a previous infection (P < .001). Vaccine type (anti-S1: P < .0001; anti-RBD: P = .0045), comorbidities (anti-S1: P = .0274; anti-RBD: P = .0048) and the use of G-CSF (anti-S1: P = .0151) negatively affected the antibody response. Conversely, previous exposure to SARS-CoV-2 significantly enhanced the response to vaccination (anti-S1: P < .0001; anti-RBD: P = .0026). Vaccine immunogenicity in cancer patients with a previous exposure to SARS-CoV-2 seems comparable to that of healthy subjects. On the other hand, clinical variables of immune frailty negatively affect humoral immune response to vaccination. 相似文献
9.
Henry Velazquez-Soto Fernanda Real Maria C Jim nez-Mart nez 《World Journal of Immunology》2022,12(1):1-8
Co-stimulatory molecules are key mediators in the regulation of immune responses and knowledge of its different families, structure, and functions has improved in recent decades. Understanding the role of co-stimulatory molecules in pathological processes has allowed the development of strategies to modulate cellular functions. Currently, modulation of co-stimulatory and co-inhibitory molecules has been applied in clinical applications as therapeutic targets in diseases and promising results have been achieved. 相似文献
10.
Tiago Ribeiro Leal Larissa Chaves Morais de Lima rick Tssio Barbosa Neves Maria Jacinta Arêa Leo Lopes Araújo Arruda Matheus Frana Perazzo Saul Martins Paiva Júnia Maria Serra-Negra Fernanda de Morais Ferreira Ana Flvia Granville-Garcia 《International journal of paediatric dentistry / the British Paedodontic Society [and] the International Association of Dentistry for Children》2022,32(1):22-30