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1.
Yang Luan Yan Zhang Kai Cui Fan Li Baolong Qin Yajun Ruan Kun Tang Hongyang Jiang Hao Li Xiaoyi Yuan Zhuo Liu Xiaming Liu Gan Yu Shengfei Xu Ruibao Chen Huan Yang Xiaolin Guo Xiaoyong Zeng Zhong Chen Zhiqiang Chen Zhiquan Hu Xiaodong Song Zhihua Wang Shaogang Wang Jihong Liu Tao Wang 《Translational andrology and urology》2021,10(1):466
BackgroundTo introduce and determine the value of optimized strategies for the management of urological tube-related emergencies with increased incidence, complexity and operational risk during the global spread of coronavirus disease 2019 (COVID-19).MethodsAll emergent urological patients at Tongji Hospital, Wuhan, during the period of January 23 (the beginning of lockdown in Wuhan) to March 23, 2020, and the corresponding period in 2019 were recruited to form this study’s COVID-19 group and control group, respectively. Tongji Hospital has the most concentrated and strongest Chinese medical teams to treat the largest number of severe COVID-19 patients. Patients in the control group were routinely treated, while patients in the COVID-19 group were managed following the optimized principles and strategies. The case incidence for each type of tube-related emergency was recorded. Baseline characteristics and management outcomes (surgery time, secondary complex operation rate, readmission rate, COVID-19 infection rate) were analyzed and compared across the control and COVID-19 periods.ResultsThe total emergent urological patients during the COVID-19 period was 42, whereas during the control period, it was 124. The incidence of tube-related emergencies increased from 53% to 88% (P<0.001) during the COVID-19 period. In particular, the incidence of nephrostomy tube-related (31% vs. 15%, P=0.027) and single-J stent-related problems (19% vs. 6%, P=0.009) increased significantly. The mean surgery times across the two periods were comparable. The number of secondary complex operations increased from 12 (18%) to 14 (38%) (P=0.028) during the COVID 19-period. The number of 2-week postoperative readmission decreased from 10 (15%) to 1 (3%) (P=0.049). No participants contracted during the COVID-19 period.ConclusionsUrological tube-related emergencies have been found to have a higher incidence and require more complicated and dangerous operations during the COVID-19 pandemic. However, the optimized management strategies introduced in this study are efficient, and safe for both urologists and patients. 相似文献
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H.F. Luan Z.B. Zhao J.Y. Feng J.Z. Cui X.B. Zhang P. Zhu Y.H. Zhang 《Brazilian journal of medical and biological research》2015,48(2):186-190
Myoclonus induced by etomidate during induction of general anesthesia is undesirable.
This study evaluated the effect of dexmedetomidine (DEX) pretreatment on the
incidence and severity of etomidate-induced myoclonus. Ninety patients undergoing
elective surgical procedures were randomly allocated to three groups (n=30 each) for
intravenous administration of 10 mL isotonic saline (group I), 0.5 µg/kg DEX in 10 mL
isotonic saline (group II), or 1.0 µg/kg DEX in 10 mL isotonic saline (group III)
over 10 min. All groups subsequently received 0.3 mg/kg etomidate by intravenous push
injection. The incidence and severity of myoclonus were recorded for 1 min after
etomidate administration and the incidence of cardiovascular adverse events that
occurred between the administration of the DEX infusion and 1 min after tracheal
intubation was recorded. The incidence of myoclonus was significantly reduced in
groups II and III (30.0 and 36.7%), compared with group I (63.3%). The incidence of
severe sinus bradycardia was significantly increased in group III compared with group
I (P<0.05), but there was no significant difference in heart rate in groups I and
II. There were no significant differences in the incidence of low blood pressure
among the 3 groups. Pretreatment with 0.5 and 1.0 µg/kg DEX significantly reduced the
incidence of etomidate-induced myoclonus during anesthetic induction; however, 0.5
µg/kg DEX is recommended because it had fewer side effects. 相似文献
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Min Luan Hong Liang Fen Yang Wei Yuan Aimin Chen Xiao Liu Honglei Ji Sheng Wen Maohua Miao 《International journal of hygiene and environmental health》2019,222(3):513-523
Background
Polybrominated diphenyl ethers (PBDEs) are major brominated flame retardant (BFR) chemicals with endocrine-disrupting properties. One small-scale study on humans has suggested that prenatal exposure to PBDEs is adversely related to anogenital distance (AGD) a sensitive marker for prenatal androgen exposure. The aim of the present study was to examine the associations between prenatal exposure to PBDEs and AGD among boys 0–4 years of age in a cohort study.Methods
In the Shanghai-Minhang Birth Cohort Study (S-MBCS), nine PBDE congeners were measured in cord plasma of 192 male infants. We measured anopenile distance (AGDAP) and anoscrotal distance (AGDAS) at birth, 6 months, 12 months, and 48 months of age. A total of 190 boys with neonatal concentrations of PBDEs (ng/g lipid) who had at-least one AGD measurement were included in our study. Information on potential confounding variables were collected through in-person interviews. Multiple linear regression models and generalized estimating equation (GEE) models were used to evaluate the associations between prenatal PBDEs concentrations and AGD.Results
Among the nine congeners, BDE-47 had the highest detection rate (83.68%) and the highest median concentration (0.18?ng/g lipid). Boys who had neonatal concentration of BDE-47 or Σ4PBDEs (sum of BDE-47, BDE-99, BDE-100, and BDE-153) in the higher quartile generally had shorter AGDAP and AGDAS than those in the first quartile. Significant inverse associations were found between AGDAS and fourth quartile BDE-47 levels among boys 12 months and 48 months of age (β?=??5.57, 95% confidence interval (CI): ?9.89, ?1.25 for 12 month of age; β?=??4.32, 95% CI: ?8.18, ?0.46 for 48 month of age). Inverse associations were also observed between AGDAS and fourth quartile Σ4PBDEs levels among boys 12 months of age (β?=??5.13, 95% CI: ?9.89, ?1.25). In GEE models, similar patterns of association were also observed between BDE-47 and AGDAS.Conclusions
Our findings provide preliminary evidence that prenatal exposure to BDE-47 and Σ4PBDEs, even at low environmental levels, may be associated with shorter AGD in boys. This data suggest that prenatal exposure to PBDEs may have adverse effects on male reproductive development. Further studies should be conducted to validate these results. 相似文献6.
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Huiling Luan Zhaojiong Huo Zifeng Zhao Shoukang Zhang Yihai Huang Yanhui Shen Pu Wang Junxiao Xi Jingyu Liang Feihua Wu 《Phytotherapy research : PTR》2020,34(6):1455-1466
High levels of consumption of saturated lipids have been largely associated with the increasing prevalence of metabolic diseases. In particular, saturated fatty acids such as palmitic acid (PA) have been implicated in the development of insulin resistance (IR). Scutellarin (Scu) is one of the effective traditional Chinese medicines considered beneficial for liver diseases and diabetes. In this study, we investigated the effect of Scu on IR and lipid metabolism disorders in vitro and in high fat diet (HFD)‐fed mice. In vitro, we found that Scu decreased insulin‐dependent lipid accumulation and the mRNA expression of CD36, Fasn, and ACC in PA‐treated HepG2 cells. Additionally, Scu upregulated Akt phosphorylation and improved the insulin signalling pathway. Moreover, Scu downregulated mammalian target of rapamycin (mTOR) phosphorylation and the n‐SREBP‐1c protein level and also reduced lipid accumulation via the mTOR‐dependent pathway, as confirmed by the molecular docking of Scu to mTOR. In HFD‐fed C57BL/6 mice, Scu improved oral glucose tolerance, pyruvate tolerance and the IR index and also increased the Akt phosphorylation level. Moreover, Scu reduced hepatocyte steatosis, decreased lipid accumulation and triglyceride levels, inhibited mTOR phosphorylation, and decreased the SREBP‐1c level in the liver. Taken together, these findings suggest that Scu ameliorates hepatic IR by regulating hepatocyte lipid metabolism via the mTOR‐dependent pathway through SREBP‐1c suppression. 相似文献
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【摘要】 目的 回顾分析奥马珠单抗治疗慢性自发性荨麻疹(CSU)的疗效、安全性及停药复发情况。方法 回顾北京大学第一医院皮肤科门诊2018年2月至2021年1月使用奥马珠单抗治疗的CSU病例,分析其临床特征,采用门诊随访形式,通过荨麻疹控制评分(UCT)、皮肤病生活质量指数(DLQI)评估疾病严重程度,监测不良事件及停药后复发情况。正态分布的计量资料组间比较采用独立样本t检验或方差分析,非正态分布的计量资料组间比较采用Mann-Whitney U检验、Wilcoxon符号秩和检验或Kruskal-Wallis H检验,计数资料组间比较采用卡方检验或Fisher 精确检验。结果 纳入59例CSU患者,奥马珠单抗治疗至少3个月,其中45例治疗达6个月,15例达12个月。经奥马珠单抗治疗,UCT从基线期3.0(1.0,6.0)分上升至第1个月11.0 (3.0,14.0)分和第3个月15.0 (12.0,16.0)分(均P < 0.05)。DLQI从基线期16.0(12.0,20.0)分下降至第1个月7.0 (1.0,13.0)分和第3个月1.0 (0.0,4.0)分(均P < 0.05)。疾病部分或完全控制的比例在基线期为0,第1个月上升至44.1%,第3个月达78.0%,第6个月达88.9%。疾病对生活质量存在重度或极重度影响的比例在基线期为84.7%,第1个月降至30.5%,第3个月降至15.3%,第6个月降至4.4%。对奥马珠单抗治疗完全反应组和部分反应组比无反应组病程更短(t = -2.894,P = 0.011;t = -2.511,P = 0.036);完全反应组比部分反应组和无反应组治疗时间更长(t = 2.479,P = 0.039;t = 2.677,P = 0.022)。慢反应组与快反应组相比,基线DLQI更高(Z = -2.622,P = 0.009),基线UCT更低(Z = -2.746,P = 0.006)。19例患者病情完全控制后停药,其中13例(68.4%)在停药7(5,8)周后复发,复发后UCT评分高于治疗前(Z = 3.172,P = 0.001),复发组比未复发组病程更长(Z = -2.635,P = 0.007)。复发后5例重新开始奥马珠单抗治疗,均再次得到部分或完全控制。治疗期间报告不良反应事件均为轻中度。结论 奥马珠单抗能够有效控制CSU症状,提高患者生活质量,且安全性较好,但停药后复发率高,复发后重新开始奥马珠单抗治疗仍有效。 相似文献
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