急性和慢性缺血性病变在多脑血管病变中的临床意义

正摘要目的探讨3.0 T MR多区域病变模式(MTLP)中急、慢性缺血性的关系及其病因学,特别是与房颤相关的脑卒中。方法分析1 000多项研究的数据,这是一项连续纳入     

双能CT碘基图:用于评估胸膜癌病

正摘要目的评估能谱CT在鉴别非钙化性良性胸膜病变和胸膜癌的作用。材料与方法本项为回顾性研究,对2016年6月1日—2018年7月1日期间经组织病理学或影像检     

研究经皮经肝胆管引流术后30 d内重新住院的原因和频率

正摘要目的研究经皮经肝胆管引流(PTBD)术后30 d内病人重新住院的原因和频率。材料与方法本研究对一家三级医疗机构从2008年6月—2013年5月期间所有行PTBD     

Schwann cell extracellular vesicles:judging a book by its cover

<正>Schwann cells (SCs) are essential in the development of the peripheral nervous system(PNS),in PNS inj ury,and the aging PNS.SCs comprise greater than 90%of the nucleated cells in peripheral nerves (Campana,2007).Myelinating SCs insulate large-diameter axons,forming a 1:1relationship and promoting saltatory conduction of axonal action potentials.Non-myelinating SCs ensheathe clusters of smaller diameter axons in Remak bundles.Both types of SCs provide essential metabolic and trophic supp...     

用于MRI心壁分割的触控笔/平板用户输入装置的有效性和易用性

正摘要目的本研究拟确定进行CMR分割时应用触控笔用户输入设备(UID)是否优于使用鼠标。方法连续纳入25例临床心脏MR(CMR)检查,影像分析由4名观察者独立进     

接受经皮穿刺动脉栓塞术的大型多中心队列研究中自发性软组织血肿死亡率的预测因子

正摘要目的评价经皮动脉栓塞(PTAE)治疗自发性软组织血肿(SSTH)的安全性和有效性,并确定短期预后的预测变量。材料与方法对2011—2017年期间的112例病人的临     

在MRI和CT检查中含铜避孕器的风险评估:宫内植入避孕器对女性的影响

正摘要目的评估宫内植入含铜避孕器(IUD)者在MRI和CT检查中的风险。方法本实验中建立了一个适合本项研究的仿真体模。选取7种不同类型的含铜IUD,在1.5 T和     

Gender differences,outcomes and trends among nonagenarian with atrial fibrillation:insight from National Inpatient Sample database

BACKGROUND Nonagenarians(NG),individuals aged≥90 years,constitute an increasing proportion of hospitalizations presenting with atrial fibrillation(AF).However,not much is known about demographics,clinical outcomes,and trends of hospitalizations.Therefore,we analyzed data about hospitalizations and clinical outcomes among NGs with AF over ten years from 2005 to 2014 using a publically available database,the National Inpatient Sample.METHODS All hospitalizations and major outcomes of subjects≥90 years with a primary diagnosis of AF(ICD-9-CM code 427.31)over a ten-year period were assessed in this study by multivariate logistic regression analysis.RESULTS There were more females than males(176,268 females,51,384 males)in this analysis.The number of hospitalizations for AF among NG increased by 50%(17,295 in 2005 to 25,830 in 2014).Males were more likely to undergo cardioversion(6.14%of males vs.5.06%of females,P<0.0001).Over this period,in-hospital mortality declined from 3.21%in 2005 to 2.38%in 2014(P=0.0041),with higher in-hospital mortality in males(3.23%in males vs.2.76%in females,P=0.0138),mean length of hospitalization decreased from 4.53 days to 4.13 days(P<0.0001),the prevalence of congestive heart failure fell from 0.48%to 0.23%(P=0.0257),and the use of anticoagulation increased from 6.09%to 14.54%(P<0.0001).In a multivariate analysis,hospital admission on the weekend,Elixhauser comorbidity index,CHA2DS2VASc score,acute respiratory failure,and the length of hospital stay were associated with a higher risk of in-hospital mortality.CONCLUSIONS From 2005 to 2014,AF-related hospitalizations among NGs increased,more so in in females population,mortality trends improved,rates of anticoagulation increased,and cardioversions increased.Despite the decreasing trend of in-hospital mortality since 2005,the relatively high mortality rate in males warrants further studies.     

Inhibition of focal adhesion kinase enhances antitumor response of radiation therapy in pancreatic cancer through CD8+ T cells

Objective:Pancreatic ductal adenocarcinoma(PDAC)is a deadly malignancy,due in large part to its resistance to conventional therapies,including radiotherapy(RT).Despite RT exerting a modest antitumor response,it has also been shown to promote an immunosuppressive tumor microenvironment.Previous studies demonstrated that focal adhesion kinase inhibitors(FAKi)in clinical development inhibit the infiltration of suppressive myeloid cells and T regulatory(T regs)cells,and subsequently enhance effector T cell infiltration.FAK inhibitors in clinical development have not been investigated in combination with RT in preclinical murine models or clinical studies.Thus,we investigated the impact of FAK inhibition on RT,its potential as an RT sensitizer and immunomodulator in a murine model of PDAC.Methods:We used a syngeneic orthotopic murine model to study the effect of FAKi on hypofractionated RT.Results:In this study we showed that IN10018,a small molecular FAKi,enhanced antitumor response to RT.Antitumor activity of the combination of FAKi and RT is T cell dependent.FAKi in combination with RT enhanced CD8+T cell infiltration significantly in comparison to the radiation or FAKi treatment alone(P<0.05).FAKi in combination with radiation inhibited the infiltration of granulocytes but enhanced the infiltration of macrophages and T regs in comparison with the radiation or FAKi treatment alone(P<0.01).Conclusions:These results support the clinical development of FAKi as a radiosensitizer for PDAC and combining FAKi with RT to prime the tumor microenvironment of PDAC for immunotherapy.