全文获取类型
收费全文 | 3330篇 |
免费 | 240篇 |
国内免费 | 67篇 |
专业分类
耳鼻咽喉 | 25篇 |
儿科学 | 127篇 |
妇产科学 | 24篇 |
基础医学 | 381篇 |
口腔科学 | 77篇 |
临床医学 | 372篇 |
内科学 | 831篇 |
皮肤病学 | 85篇 |
神经病学 | 186篇 |
特种医学 | 389篇 |
外科学 | 335篇 |
综合类 | 57篇 |
一般理论 | 2篇 |
预防医学 | 147篇 |
眼科学 | 72篇 |
药学 | 163篇 |
中国医学 | 9篇 |
肿瘤学 | 355篇 |
出版年
2023年 | 17篇 |
2021年 | 45篇 |
2020年 | 36篇 |
2019年 | 54篇 |
2018年 | 70篇 |
2017年 | 49篇 |
2016年 | 53篇 |
2015年 | 87篇 |
2014年 | 123篇 |
2013年 | 155篇 |
2012年 | 187篇 |
2011年 | 169篇 |
2010年 | 142篇 |
2009年 | 142篇 |
2008年 | 139篇 |
2007年 | 193篇 |
2006年 | 161篇 |
2005年 | 147篇 |
2004年 | 123篇 |
2003年 | 118篇 |
2002年 | 116篇 |
2001年 | 87篇 |
2000年 | 80篇 |
1999年 | 77篇 |
1998年 | 89篇 |
1997年 | 90篇 |
1996年 | 114篇 |
1995年 | 82篇 |
1994年 | 69篇 |
1993年 | 64篇 |
1992年 | 47篇 |
1991年 | 27篇 |
1990年 | 36篇 |
1989年 | 44篇 |
1988年 | 44篇 |
1987年 | 50篇 |
1986年 | 54篇 |
1985年 | 51篇 |
1984年 | 20篇 |
1983年 | 20篇 |
1982年 | 22篇 |
1981年 | 15篇 |
1980年 | 16篇 |
1979年 | 11篇 |
1978年 | 15篇 |
1977年 | 11篇 |
1976年 | 16篇 |
1975年 | 15篇 |
1973年 | 7篇 |
1971年 | 8篇 |
排序方式: 共有3637条查询结果,搜索用时 31 毫秒
1.
Li Bai Saeha Shin Richard T. Burnett Jeffrey C. Kwong Perry Hystad Aaron van Donkelaar Mark S. Goldberg Eric Lavigne Scott Weichenthal Randall V. Martin Ray Copes Alexander Kopp Hong Chen 《International journal of cancer. Journal international du cancer》2020,146(9):2450-2459
Lung and female breast cancers are highly prevalent worldwide. Although the association between exposure to ambient fine particulate matter (PM2.5) and lung cancer has been recognized, there is less evidence for associations with other common air pollutants such as nitrogen dioxide (NO2) and ozone (O3). Even less is known about potential associations between these pollutants and breast cancer. We conducted a population-based cohort study to investigate the associations of chronic exposure to PM2.5, NO2, O3 and redox-weighted average of NO2 and O3 (Ox) with incident lung and breast cancer, using the Ontario Population Health and Environment Cohort (ONPHEC), which includes all long-term residents aged 35–85 years who lived in Ontario, Canada, 2001–2015. Incident lung and breast cancers were ascertained using the Ontario Cancer Registry. Annual estimates of exposures were assigned to the residential postal codes of subjects for each year during follow-up. We used Cox proportional-hazards models adjusting for personal- and neighborhood-level covariates. Our cohorts for lung and breast cancer analyses included ~4.9 million individuals and ~2.5 million women, respectively. During follow-up, 100,146 incident cases of lung cancer and 91,146 incident cases of breast cancer were diagnosed. The fully adjusted analyses showed positive associations of lung cancer incidence with PM2.5 (hazard ratio [HR] = 1.02 [95% CI: 1.01–1.05] per 5.3 μg/m3) and NO2 (HR = 1.05 [95% CI: 1.03–1.07] per 14 ppb). No associations with lung cancer were observed for O3 or Ox. Relationships between PM2.5 and NO2 with lung cancer exhibited a sublinear shape. We did not find compelling evidence linking air pollution to breast cancer. 相似文献
2.
3.
4.
5.
Elizabeth S. Gabitzsch Kwong Yok Tsang Claudia Palena Justin M. David Massimo Fantini Anna Kwilas Adrian E. Rice Yvette Latchman James W. Hodge James L. Gulley Ravi A. Madan Christopher R. Heery Joseph P. Balint Jr. Frank R. Jones Jeffrey Schlom 《Oncotarget》2015,6(31):31344-31359
Phenotypic heterogeneity of human carcinoma lesions, including heterogeneity in expression of tumor-associated antigens (TAAs), is a well-established phenomenon. Carcinoembryonic antigen (CEA), MUC1, and brachyury are diverse TAAs, each of which is expressed on a wide range of human tumors. We have previously reported on a novel adenovirus serotype 5 (Ad5) vector gene delivery platform (Ad5 [E1-, E2b-]) in which regions of the early 1 (E1), early 2 (E2b), and early 3 (E3) genes have been deleted. The unique deletions in this platform result in a dramatic decrease in late gene expression, leading to a marked reduction in host immune response to the vector. Ad5 [E1-, E2b-]-CEA vaccine (ETBX-011) has been employed in clinical studies as an active vaccine to induce immune responses to CEA in metastatic colorectal cancer patients. We report here the development of novel recombinant Ad5 [E1-, E2b-]-brachyury and-MUC1 vaccine constructs, each capable of activating antigen-specific human T cells in vitro and inducing antigen-specific CD4+ and CD8+ T cells in vaccinated mice. We also describe the use of a combination of the three vaccines (designated Tri-Ad5) of Ad5 [E1-, E2b-]-CEA, Ad5 [E1-, E2b-]-brachyury and Ad5 [E1-, E2b-]-MUC1, and demonstrate that there is minimal to no “antigenic competition” in in vitro studies of human dendritic cells, or in murine vaccination studies. The studies reported herein support the rationale for the application of Tri-Ad5 as a therapeutic modality to induce immune responses to a diverse range of human TAAs for potential clinical studies. 相似文献
6.
7.
8.
9.
Fu‐Chun Zhou MD PhD Yu‐Tao Xiang MD PhD Chuan‐Yue Wang MD PhD Faith Dickerson PhD Julie Kreyenbuhl PharmD PhD Gabor S. Ungvari MD PhD Raymond W. C. Au PhD Jing‐Jing Zhou MPhil Yan Zhou BA David Shum PhD David Man PhD Kelly Y. C. Lai MRCPsy Wai‐Kwong Tang MRCPsy Xin Yu MD Helen F. K. Chiu FRCPsy 《Perspectives in psychiatric care》2014,50(2):102-110
10.
Ava Kwong BSc MBBS PhD FRCS Wai Wang Chau BSc MSc Oscar W. K. Mang MSc CStat Connie H. N. Wong MSc BSc Dacita T. K. Suen MBBS R. Leung MBCHB MRCP Kerry Wong BSc MBiostats Andrea Lee Catherine Shea MBBS Elliot Morse Stephen C. K. Law MBBS FRCR 《Annals of surgical oncology》2014,21(4):1246-1253