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Tetsuji Terazawa Takeshi Kato Masahiro Goto Katsuya Ohta Shingo Noura Hironaga Satake Yoshinori Kagawa Hisato Kawakami Hiroko Hasegawa Kazuhiro Yanagihara Tatsushi Shingai Ken Nakata Masahito Kotaka Masayuki Hiraki Ken Konishi Shiro Nakae Daisuke Sakai Yukinori Kurokawa Toshio Shimokawa Taroh Satoh 《The oncologist》2021,26(1):17-e47
Lessons Learned
- Panitumumab monotherapy showed favorable efficacy and feasibility in the treatment of frail or elderly patients with RAS wild‐type unresectable colorectal cancer.
- It is especially effective for left‐sided tumors; therefore, panitumumab as first‐line treatment could be an additional therapeutic option for frail elderly patients, particularly in those who are unsuitable for upfront oxaliplatin‐based or irinotecan‐based combination regimens.
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Robert J. Marquardt Sung-Min Cho Prateek Thatikunta Abhishek Deshpande Dolora Wisco Ken Uchino 《Journal of stroke and cerebrovascular diseases》2019,28(8):2207-2212
Objectives: To evaluate the safety of acute ischemic stroke (AIS) therapy in patients with infective endocarditis (IE) with intravenous thrombolysis (IVT) or endovascular therapy (EVT) such as mechanical thrombectomy. Methods: We conducted a retrospective study of patients who underwent AIS therapy with IVT or EVT at a tertiary referral center from 2013 to 2017, that were later diagnosed with acute IE as the causative mechanism. We then performed a systematic review of reports of acute ischemic reperfusion therapy in IE since 1995 for their success rates in terms of neurological outcome, and mortality, and their risk of hemorrhagic complication. Results: In the retrospective portion, 8 participants met criteria, of whom 4 received IVT and 4 received EVT. Through systematic review, 24 publications of 32 participants met criteria. Combined, a total of 40 participants were analyzed: 18 received IVT alone, 1 received combined IVT plus EVT, and 21 received EVT alone. IVT compared to EVT were similar in rates of good neurologic outcomes (58% versus 76%, P= .22) and mortality (21% versus 19%, P= .87), but had higher post-therapy intracranial hemorrhage (63% versus 18% [P= .006]). Conclusion: IV thrombolysis has a higher rate of post-therapy intracranial hemorrhage compared to EVT. EVT should be considered as first-line AIS therapy for patients with known, or suspected, IE who present with a large vessel occlusion. 相似文献
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Circles of Support and Accountability (CoSA) is a promising reintegration framework whereby community volunteers support individuals convicted for sexual offenses to reintegrate safely into the community. CoSA has grown in popularity, yet little is known about volunteers’ experiences of CoSA, including how they cope with their core member being recalled or reoffending. The aim of the current study is to explore the experiences of CoSA volunteers in New Zealand. In-depth interviews were used to explore experiences. The findings relating to general experiences explored balancing risk management and social support, questioning the place of religion in CoSA, confronting stereotypes, and volunteering in a risk-averse society. The findings also revealed both the commitment to CoSA, and the stress and guilt felt by the volunteers following a recall or re-offense. Findings are discussed in terms of their implications for current and ongoing volunteers, as well as for community approaches to criminal justice. 相似文献
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Naoko Chayahara Toru Mukohara Motoko Tachihara Yoshimi Fujishima Atsushi Fukunaga Ken Washio Masatsugu Yamamoto Kyosuke Nakata Kazuyuki Kobayashi Kei Takenaka Masanori Toyoda Naomi Kiyota Kazutoshi Tobimatsu Hisayo Doi Naomi Mizuta Naho Marugami Atsushi Kawaguchi Chikako Nishigori Yoshihiro Nishimura Hironobu Minami 《The oncologist》2019,24(7):885-e413
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John A. Kalapurakal Mahesh Gopalakrishnan David O. Walterhouse Cynthia K. Rigsby Alfred Rademaker Irene Helenowski Sandy Kessel Karen Morano Fran Laurie Ken Ulin Natia Esiashvili Howard Katzenstein Karen Marcus David S. Followill Suzanne L. Wolden Anita Mahajan Thomas J. Fitzgerald 《International journal of radiation oncology, biology, physics》2019,103(1):28-37
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Yasmine Abouleila Kaoru Onidani Ahmed Ali Hirokazu Shoji Takayuki Kawai Chwee Teck Lim Vipin Kumar Shinobu Okaya Ken Kato Eiso Hiyama Toshio Yanagida Tsutomu Masujima Yoshihiro Shimizu Kazufumi Honda 《Cancer science》2019,110(2):697-706
Recently, there has been increased attention on the analysis of circulating tumor cells (CTCs), also known as liquid biopsy, owing to its potential benefits in cancer diagnosis and treatment. Circulating tumor cells are released from primary tumor lesions into the blood stream and eventually metastasize to distant body organs. However, a major hurdle with CTC analysis is their natural scarcity. Existing methods lack sensitivity, specificity, or reproducibility required in CTC characterization and detection. Here, we report untargeted molecular profiling of single CTCs obtained from gastric cancer and colorectal cancer patients, using live single cell mass spectrometry integrated with microfluidics‐based cell enrichment techniques. Using this approach, we showed the difference in the metabolomic profile between CTCs originating from different cancer groups. Moreover, potential biomarkers were putatively annotated to be specific to each cancer type. 相似文献
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