全文获取类型
收费全文 | 205691篇 |
免费 | 15105篇 |
国内免费 | 720篇 |
专业分类
耳鼻咽喉 | 2271篇 |
儿科学 | 5438篇 |
妇产科学 | 4287篇 |
基础医学 | 26319篇 |
口腔科学 | 4501篇 |
临床医学 | 19682篇 |
内科学 | 43053篇 |
皮肤病学 | 2743篇 |
神经病学 | 19856篇 |
特种医学 | 6905篇 |
外国民族医学 | 13篇 |
外科学 | 32660篇 |
综合类 | 3375篇 |
一般理论 | 291篇 |
预防医学 | 18660篇 |
眼科学 | 4325篇 |
药学 | 14274篇 |
1篇 | |
中国医学 | 374篇 |
肿瘤学 | 12488篇 |
出版年
2023年 | 750篇 |
2021年 | 2658篇 |
2020年 | 2078篇 |
2019年 | 3358篇 |
2018年 | 3936篇 |
2017年 | 3205篇 |
2016年 | 3330篇 |
2015年 | 4019篇 |
2014年 | 6051篇 |
2013年 | 8787篇 |
2012年 | 13101篇 |
2011年 | 14289篇 |
2010年 | 8065篇 |
2009年 | 7274篇 |
2008年 | 13573篇 |
2007年 | 14408篇 |
2006年 | 13894篇 |
2005年 | 14379篇 |
2004年 | 13785篇 |
2003年 | 12882篇 |
2002年 | 12394篇 |
2001年 | 1829篇 |
2000年 | 1401篇 |
1999年 | 1867篇 |
1998年 | 2421篇 |
1997年 | 1993篇 |
1996年 | 1751篇 |
1995年 | 1898篇 |
1994年 | 1712篇 |
1993年 | 1600篇 |
1992年 | 1165篇 |
1991年 | 1143篇 |
1990年 | 1041篇 |
1989年 | 938篇 |
1988年 | 985篇 |
1987年 | 997篇 |
1986年 | 978篇 |
1985年 | 1062篇 |
1984年 | 1434篇 |
1983年 | 1423篇 |
1982年 | 1769篇 |
1981年 | 1602篇 |
1980年 | 1517篇 |
1979年 | 777篇 |
1978年 | 924篇 |
1977年 | 901篇 |
1976年 | 806篇 |
1975年 | 660篇 |
1974年 | 652篇 |
1973年 | 578篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Alzina Koric MPP Chun-Pin Chang PhD Bayarmaa Mark MS Kerry Rowe PhD John Snyder PhD Mark Dodson MD Vikrant G. Deshmukh PhD Michael G. Newman MS Alison M. Fraser MPH Ken R. Smith PhD Ankita P. Date MS Lisa H. Gren PhD Christina A. Porucznik PhD Benjamin A. Haaland PhD N. Lynn Henry MD Mia Hashibe PhD 《Cancer》2022,128(14):2826-2835
2.
3.
Thomas Behrens Calvin Ge Roel Vermeulen Benjamin Kendzia Ann Olsson Joachim Schüz Hans Kromhout Beate Pesch Susan Peters Lützen Portengen Per Gustavsson Dario Mirabelli Pascal Guénel Danièle Luce Dario Consonni Neil E. Caporaso Maria Teresa Landi John K. Field Stefan Karrasch Heinz-Erich Wichmann Jack Siemiatycki Marie-Elise Parent Lorenzo Richiardi Lorenzo Simonato Karl-Heinz Jöckel Wolfgang Ahrens Hermann Pohlabeln Guillermo Fernández-Tardón David Zaridze John R. McLaughlin Paul A. Demers Beata Świątkowska Jolanta Lissowska Tamás Pándics Eleonora Fabianova Dana Mates Vladimir Bencko Lenka Foretova Vladimír Janout Paolo Boffetta Bas Bueno-de-Mesquita Francesco Forastiere Kurt Straif Thomas Brüning 《International journal of cancer. Journal international du cancer》2023,152(4):645-660
There is limited evidence regarding the exposure-effect relationship between lung-cancer risk and hexavalent chromium (Cr(VI)) or nickel. We estimated lung-cancer risks in relation to quantitative indices of occupational exposure to Cr(VI) and nickel and their interaction with smoking habits. We pooled 14 case-control studies from Europe and Canada, including 16 901 lung-cancer cases and 20 965 control subjects. A measurement-based job-exposure-matrix estimated job-year-region specific exposure levels to Cr(VI) and nickel, which were linked to the subjects' occupational histories. Odds ratios (OR) and associated 95% confidence intervals (CI) were calculated by unconditional logistic regression, adjusting for study, age group, smoking habits and exposure to other occupational lung carcinogens. Due to their high correlation, we refrained from mutually adjusting for Cr(VI) and nickel independently. In men, ORs for the highest quartile of cumulative exposure to CR(VI) were 1.32 (95% CI 1.19-1.47) and 1.29 (95% CI 1.15-1.45) in relation to nickel. Analogous results among women were: 1.04 (95% CI 0.48-2.24) and 1.29 (95% CI 0.60-2.86), respectively. In men, excess lung-cancer risks due to occupational Cr(VI) and nickel exposure were also observed in each stratum of never, former and current smokers. Joint effects of Cr(VI) and nickel with smoking were in general greater than additive, but not different from multiplicative. In summary, relatively low cumulative levels of occupational exposure to Cr(VI) and nickel were associated with increased ORs for lung cancer, particularly in men. However, we cannot rule out a combined classical measurement and Berkson-type of error structure, which may cause differential bias of risk estimates. 相似文献
4.
5.
6.
Devin Incerti Xiang-Ming Xu Jacquelyn W. Chou Nina Gonzaludo John W. Belmont Brock E. Schroeder 《Genetics in medicine》2022,24(1):109-118
PurposeTo estimate the cost-effectiveness of genome sequencing (GS) for diagnosing critically ill infants and noncritically ill pediatric patients (children) with suspected rare genetic diseases from a United States health sector perspective.MethodsA decision-analytic model was developed to simulate the diagnostic trajectory of patients. Parameter estimates were derived from a targeted literature review and meta-analysis. The model simulated clinical and economic outcomes associated with 3 diagnostic pathways: (1) standard diagnostic care, (2) GS, and (3) standard diagnostic care followed by GS.ResultsFor children, costs of GS ($7284) were similar to that of standard care ($7355) and lower than that of standard care followed by GS pathways ($12,030). In critically ill infants, when cost estimates were based on the length of stay in the neonatal intensive care unit, the lowest cost pathway was GS ($209,472). When only diagnostic test costs were included, the cost per diagnosis was $17,940 for standard, $17,019 for GS, and $20,255 for standard care followed by GS.ConclusionThe results of this economic model suggest that GS may be cost neutral or possibly cost saving as a first line diagnostic tool for children and critically ill infants. 相似文献
7.
8.
9.
Aline Rangel-Pozzo Filipe F. dos Santos Tinuccia Dettori Matteo Giulietti Daniela Virginia Frau Pedro A. F. Galante Roberta Vanni Alok Pathak Gabor Fischer John Gartner Paola Caria Sabine Mai 《International journal of cancer. Journal international du cancer》2023,153(10):1842-1853
Molecular markers can serve as diagnostic tools to support pathological analysis in thyroid neoplasms. However, because the same markers can be observed in some benign thyroid lesions, additional approaches are necessary to differentiate thyroid tumor subtypes, prevent overtreatment and tailor specific clinical management. This applies particularly to the recently described variant of thyroid cancer referred to as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). This variant has an estimated prevalence of 4.4% to 9.1% of all papillary thyroid carcinomas worldwide. We studied 60 thyroid lesions: 20 classical papillary thyroid carcinoma (CPTC), 20 follicular variant of PTC (FVPTC) and 20 NIFTP. We examined morphological and molecular features to identify parameters that can differentiate NIFTP from the other PTC subtypes. When blindly investigating the nuclear architecture of thyroid neoplasms, we observed that NIFTP has significantly longer telomeres than CPTC and FVPTC. Super-resolved 3D-structured illumination microscopy demonstrated that NIFTP is heterogeneous and that its nuclei contain more densely packed DNA and smaller interchromatin spaces than CPTC and FVPTC, a pattern that resembles normal thyroid tissue. These data are consistent with the observed indolent biological behavior and favorable prognosis associated with NIFTP, which lacks BRAFV600E mutations. Of note, next-generation thyroid oncopanel sequencing was unable to distinguish the thyroid cancer histotypes in our study cohort. In summary, our data suggest that 3D nuclear architecture can be a powerful analytical tool to diagnose and guide clinical management of NIFTP. 相似文献
10.
Karvandi Elika Hanrahan John Gerrard Khan Danyal Zaman Boloux Pierre-Marc Bremner Fion Cabrilo Ivan Dorward Neil Grieve Joan Jackson Sue Jimenez Glenda Serrano Inma Nowak Victoria Anne Kolias Angelos Baldeweg Stephanie E. Marcus Hani Joseph 《Pituitary》2022,25(4):673-683
Pituitary - Pituitary adenomas affect patients’ quality-of-life (QoL) across several domains, with long-term implications even following gross-total resection or disease remission. While... 相似文献