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Hernández-Molina Gabriela Ruiz-Quintero Narlly Lima Guadalupe Hernández-Ramírez Diego Llorente-Chávez Amaya Saavedra-González Vanessa Jiménez-Soto Rodolfo Llorente Luis 《International ophthalmology》2022,42(8):2355-2361
International Ophthalmology - To evaluate CCL2, CXCL8, and CXCL10 in the tears of patients with Primary Sjögren’s syndrome (PSS) and correlate them with ocular symptoms/discomfort and... 相似文献
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Rikke Løvendahl Eefsen Jim S. Larsen Louise L. Klarskov Rahim Altaf Estrid Høgdall Peter Ingeholm Jakob Lykke Dorte L. Nielsen Per Pfeiffer Laurids Ø. Poulsen Camilla Qvortrup Jakob V. Schou Morten Mau-Sørensen Kell Østerlind Benny V. Jensen 《International journal of cancer. Journal international du cancer》2023,152(10):2145-2152
Therapy with immune checkpoint inhibitors (ICI) is effective in patients with metastatic mismatch-repair deficient (dMMR) colorectal cancer (CRC); however, data on treatment with neoadjuvant ICI in patients with locally advanced CRC are limited. From March 2019 to June 2020, five Danish oncological centers treated 10 patients with a treatment-naïve dMMR CRC with preoperative pembrolizumab, 9 with a nonmetastatic, unresectable colon cancer and 1 with a locally advanced rectum cancer. All 10 patients were evaluated regularly at a multidisciplinary team (MDT) meeting, and they all had a radical resection after a median of 8 cycles (range 2-13) of pembrolizumab. A microscopic evaluation of the resected tumors revealed no remaining tumor cells in five patients, while five still had tumor cells present. The patients were given no additional therapy. No recurrences were reported after a median follow-up of 26 months (range 23-38.5 months). Biopsies from Danish patients with CRC are routinely screened for dMMR proteins. In 2017, data from the Danish Colorectal Cancer Group showed that 19% (565/3000) of the patients with colon cancer and 1.5% (19/1279) of those with rectum cancer had an dMMR tumor. Among the patients with MMR determination, 26% (99/384) patients had a T4 dMMR colon cancer; thus, the 10 patients treated with neoadjuvant pembrolizumab comprised about 9% of the patients with a T4 dMMR colon cancer (9/99) and 5% of patients with dMMR rectal cancer (1/19). Therapy with pembrolizumab was feasible and effective. Larger prospective trials are needed to confirm our findings. 相似文献
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Allison F. O’Neill MD Caihong Xia PhD Mark D. Krailo PhD Furqan Shaikh MD MSc Farzana D. Pashankar MD MRCP Deborah F. Billmire MD Thomas A. Olson MD Jim F. Amatruda MD PhD Doojduen Villaluna MS Li Huang MS Marcio Malogolowkin MD Carlos Rodriguez-Galindo MD A. Lindsay Frazier MD 《Cancer》2019,125(20):3649-3656
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Luis Miguel Jiménez Muñoz Indira Sotelo Díaz Carlos Salgado Rohner Gabriela Cáez Ramirez 《Journal of Culinary Science & Technology》2019,17(2):89-102
Lionfish is an invasive and predatory species with low local consumption due to a lack of culinary knowledge of its preparation. A new way to prepare lionfish was proposed to increase variety and provide added value. The aim of this study was to evaluate the effect of high power ultrasound application on the textural properties measured by the texture profile analysis, sensory attributes, and shape preference of surimi patties (rounded and square) made from lionfish. Patties were prepared using lionfish surimi processed with ultrasound (37 kHz; 150 W), sodium citrate (0.3%), sucrose (1%), and salt (2%). Ultrasound exposure increased the hardness of the patties by 35.1%, decreased cohesiveness by 89.7%, and decreased the chewiness by 49.1%. Results show that high power ultrasound showed potential as an environmentally friendly technology to create surimi as a base for patties with sensory and textural appropriateness, increasing the potential culinary applications of lionfish. 相似文献
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