全文获取类型
收费全文 | 1371篇 |
免费 | 70篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 89篇 |
妇产科学 | 31篇 |
基础医学 | 146篇 |
口腔科学 | 45篇 |
临床医学 | 101篇 |
内科学 | 291篇 |
皮肤病学 | 24篇 |
神经病学 | 33篇 |
特种医学 | 419篇 |
外科学 | 88篇 |
综合类 | 40篇 |
预防医学 | 57篇 |
眼科学 | 5篇 |
药学 | 37篇 |
1篇 | |
肿瘤学 | 30篇 |
出版年
2023年 | 4篇 |
2021年 | 3篇 |
2020年 | 5篇 |
2019年 | 6篇 |
2018年 | 9篇 |
2017年 | 14篇 |
2016年 | 10篇 |
2015年 | 13篇 |
2014年 | 30篇 |
2013年 | 33篇 |
2012年 | 17篇 |
2011年 | 22篇 |
2010年 | 34篇 |
2009年 | 51篇 |
2008年 | 23篇 |
2007年 | 39篇 |
2006年 | 31篇 |
2005年 | 28篇 |
2004年 | 22篇 |
2003年 | 17篇 |
2002年 | 13篇 |
2001年 | 24篇 |
2000年 | 16篇 |
1999年 | 20篇 |
1998年 | 78篇 |
1997年 | 80篇 |
1996年 | 81篇 |
1995年 | 64篇 |
1994年 | 39篇 |
1993年 | 58篇 |
1992年 | 6篇 |
1991年 | 15篇 |
1990年 | 25篇 |
1989年 | 54篇 |
1988年 | 42篇 |
1987年 | 46篇 |
1986年 | 52篇 |
1985年 | 68篇 |
1984年 | 36篇 |
1983年 | 30篇 |
1982年 | 28篇 |
1981年 | 31篇 |
1980年 | 37篇 |
1979年 | 6篇 |
1978年 | 18篇 |
1977年 | 23篇 |
1976年 | 21篇 |
1975年 | 20篇 |
1958年 | 1篇 |
1914年 | 1篇 |
排序方式: 共有1445条查询结果,搜索用时 31 毫秒
1.
Isolated patellofemoral arthritis is an increasingly recognized entity, and is usually associated with previous patellofemoral dysplasia or instability. Patellofemoral arthroplasty (PFA) has evolved significantly in recent years, both in terms of implant design and importantly in the understanding of appropriate patient selection. This review outlines the indications and investigations for PFA, provides a brief history of the development of contemporary implants, and presents the clinical outcomes for the prostheses most commonly used in the UK. In addition, it provides a detailed surgical technique for implantation of an onlay implant, with tips on how to optimize patellofemoral biomechanics and thus achieve a consistently good outcome. 相似文献
2.
3.
4.
5.
Monitoring for undertransfusion 总被引:1,自引:0,他引:1
BACKGROUND: Most published reviews and audits of blood and blood component transfusion have focused on the issue of overtransfusion and on the inappropriate use of red cell components. There is growing concern that efforts to curb unnecessary transfusions may result in a trend toward undertransfusion of patients. There is little published information that addresses this issue or the magnitude of this practice. STUDY DESIGN AND METHODS: Undertransfusion was evaluated by examining the transfusion records from a 3-month period for 55 patients who met the study criteria of having either a hemoglobin level < 7 g per dL or a platelet count of < 10 × 10(9) per L. If the identified patient did not receive a transfusion within 24 hours of the reported hemoglobin level or platelet count, the medical record was reviewed by a resident physician. RESULTS: A total of 213 individual hemoglobin levels and platelet counts, representing the 55 patients, met our transfusion criteria. All except 8 of the identified patients received red cells and/or platelet transfusions. Reasons for not transfusing red cells included the patient's response to nutritional support and iron supplementation, refusal of blood, and noncompliance. Reasons for not transfusing platelets included falsely low platelet count because of platelet clumping in vitro, contraindication based on clinical diagnosis (e.g., immune thrombocytopenic purpura), and the patient's death before transfusion. CONCLUSION: Red cell and platelet transfusions were appropriately ordered for all patients who met the transfusion criteria. Undertransfusion is not a problem at this institution according to the criteria established. It is recommended that other institutions expand their blood utilization audits to include investigation for evidence of undertransfusion. Further research regarding the issue of undertransfusion is warranted and could be expanded to include other components. 相似文献
6.
Seaton RA; Naraqi S; Wembri JP; Warrell DA 《QJM : monthly journal of the Association of Physicians》1996,89(6):423-428
In Papua New Guinea, <it>Cryptococcus neoformans</it> var.
<it>gattii</it> meningitis has a high fatality rate even in
immunocompetent patients. Our retrospective study attempted to identify
marker of poor prognosis. Of 88 immunocompetent patients, 30 (34.1%) died,
usually soon after admission, and mortality was higher in men
(<it>p</it> = 0.025) and older patients (<it>p</it>
= 0.039). Death was associated with altered consciousness
(<it>p</it><0.001), a history of convulsions prior to
treatment (<it>p</it> = 0.002) and a maximum systolic blood
pressure of >150 mmHg (<it>p</it> = 0.017). These data
suggest that death results from raised intracranial pressure and subsequent
tentorial herniation. However, CSF opening pressure measured on admission
was raised in 29/36 (81%) patients and did not predict outcome. In
survivors, relapse was uncommon and was not predicted by discharge serum
cryptococcal antigen titres, which were frequently raised on completion of
therapy in asymptomatic patients. Mortality may be reduced if efforts are
made to lower intracranial pressure in those patients who present with
markers of poor prognosis.
相似文献
7.
Familial hemiplegic migraine: a clinical comparison of families linked and unlinked to chromosome 19 总被引:5,自引:0,他引:5
GM Terwindt RA Ophoff J Haan RR Frants MD Ferrari for the DMGRG 《Cephalalgia : an international journal of headache》1996,16(3):153-155
We compared the clinical characteristics of 50 patients from three unrelated families with familial hemiplegic migraine (FHM) linked to chromosome 19, with those of 20 patients from two families with FHM not linked to chromosome 19. We found no significant differences for age at onset, frequency and duration of attacks, duration of the paresis, and occurrence of basilar migraine symptoms. In the linked families, significantly more patients reported unconsciousness during attacks (39%, vs 15%; p<0.05) and provocation of attacks by mild head trauma (70% vs 40%; p< 0.05). In one linked family patients also displayed chronic progressive cerebellar ataxia, whereas in one unlinked family benign infantile convulsions occurred in addition to FHM. Interestingly, so far an association with cerebellar ataxia was only described in chromosome 19-linked families. FHM linked to chromosome 19 and FHM unlinked to chromosome 19 do not differ with respect to clinical features. 相似文献
8.
Oral cyclophosphamide versus chlorambucil in the treatment of patients with membranous nephropathy and renal insufficiency 总被引:4,自引:1,他引:4
Branten AJ; Reichert LJ; Koene RA; Wetzels JF 《QJM : monthly journal of the Association of Physicians》1998,91(5):359-366
We treated patients with idiopathic membranous nephropathy (iMGN) and renal
insufficiency, using: (i) (n = 15) monthly cycles of steroids (1 g
methyl-prednisolone i.v. on three consecutive days, followed by oral
prednisone 0.5 mg/kg/day months 1, 3 and 5) and chlorambucil (0.15
mg/kg/day months 2, 4 and 6); or (ii) (n = 17) oral cyclophosphamide
(1.5-2.0 mg/kg/day for 1 year) and steroids in a comparable dose. The
groups were comparable in age, renal function and levels of proteinuria.
During the 6 months preceding treatment, serum creatinine levels increased
from 148 +/- 50 to 219 +/- 73 mumol/l in the chlorambucil group and from
164 +/- 86 to 274 +/- 126 mumol/l in the cyclophosphamide group. Median
(range) follow-ups were: chlorambucil 38 months (8-71); cyclophosphamide 26
months (5-68) (NS). Renal function improved in both groups, but the
improvement was short-lived in the chlorambucil group; 12 months after
starting treatment, mean serum creatinine was 6.3 mumol/l lower in the
chlorambucil group and 121 mumol/l lower in the cyclophosphamide group (p
< 0.01). Four chlorambucil-treated patients developed ESRD, and five
needed a second course of therapy, whereas only one
cyclophosphamide-treated patient developed ESRD (p < 0.05). Remissions
of proteinuria occurred more frequently after cyclophosphamide treatment
(15/17 vs. 5/15; p < 0.01). Side-effects necessitated interruption of
treatment in six patients on cyclophosphamide and in 11 on chlorambucil (p
< 0.05). In our patients, oral cyclophosphamide was better tolerated
than oral chlorambucil. The suggested greater efficacy of the oral
cyclophosphamide regimen needs to be ascertained by longer follow-up.
相似文献
9.
Intra-articular Chlamydial Antigen and Inflammatory Arthritis 总被引:1,自引:0,他引:1
HUGHES RA; HYDER E; TREHARNE JD; KEAT ACS 《QJM : monthly journal of the Association of Physicians》1991,80(1):575-588
Joint material from 133 patients with well-characterized inflammatoryarthritis, including individuals likely to have suffered reactivearthiritis, was studied. The majority of patients were alsoexamined for the presence of genital tract infection with Chlamydiatrachomatis. Fluorescein-conjugated monoclonal antibodies demonstratedthe presence of C. trachomatis antigen in synovial fluid celldeposits or synovial sections from inflamed knee joints of sevenpatients with reactive arthritis. The significance of thesefindings is discussed, as is the low rate of detection of chlamydialantigen in either the genital tract or the joint from patientsin this study. We emphasize the need for further work aimedat identifying the relevant immunogenic chlamydial antigensresponsible for the initiation of reactive arthritis. 相似文献
10.