首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   27321篇
  免费   1573篇
  国内免费   241篇
耳鼻咽喉   232篇
儿科学   536篇
妇产科学   578篇
基础医学   2762篇
口腔科学   695篇
临床医学   1897篇
内科学   7862篇
皮肤病学   349篇
神经病学   2393篇
特种医学   1037篇
外科学   5151篇
综合类   55篇
一般理论   5篇
预防医学   978篇
眼科学   515篇
药学   1658篇
中国医学   55篇
肿瘤学   2377篇
  2023年   271篇
  2022年   233篇
  2021年   780篇
  2020年   579篇
  2019年   825篇
  2018年   992篇
  2017年   732篇
  2016年   860篇
  2015年   894篇
  2014年   1215篇
  2013年   1501篇
  2012年   2284篇
  2011年   2173篇
  2010年   1246篇
  2009年   1207篇
  2008年   1883篇
  2007年   1841篇
  2006年   1715篇
  2005年   1695篇
  2004年   1595篇
  2003年   1369篇
  2002年   1230篇
  2001年   127篇
  2000年   125篇
  1999年   157篇
  1998年   166篇
  1997年   140篇
  1996年   131篇
  1995年   147篇
  1994年   123篇
  1993年   115篇
  1992年   90篇
  1991年   68篇
  1990年   71篇
  1989年   52篇
  1988年   42篇
  1987年   44篇
  1986年   48篇
  1985年   43篇
  1984年   36篇
  1983年   36篇
  1982年   47篇
  1981年   28篇
  1980年   28篇
  1979年   19篇
  1978年   14篇
  1976年   12篇
  1975年   8篇
  1974年   11篇
  1933年   6篇
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Graefe's Archive for Clinical and Experimental Ophthalmology - To report a longitudinal analysis of specific optical coherence tomography (OCT) features in eyes with diabetic macular edema...  相似文献   
2.
Malignant melanoma (MM) is a highly aggressive neoplasm with a growing worldwide incidence. It is not uncommon that the disease is already metastatic at the time of the first diagnosis. Regional lymph nodes and skin are the first and most common metastatic sites, followed by distant visceral sites (lungs, liver, and central nervous system) and bone. In this clinical setting, fine-needle aspiration (FNA) often represents the first diagnostic approach. FNA is a useful tool to obtain a rapid and accurate diagnosis, in conjunction with ancillary techniques and molecular analysis, as recommended by recent guidelines. The aim of this review was to describe the cytomorphology, immunocytochemical tools, and molecular tools used for the diagnosis of MM metastases on FNA.  相似文献   
3.
4.
5.
6.
7.
8.
In 1952, renal cell carcinomas had been divided into 2 categories—clear cell or granular cell—depending upon their cytoplasmic staining characteristics. In the following years, the inventory of renal epithelial tumors has expanded by the addition of tumors named by their architectural pattern (i.e., papillary RCC, tubulocystic RCC), anatomic location (i.e., collecting duct carcinoma, renal medullary carcinoma), associated diseases (i.e., acquired cystic disease-associated RCCs). With the extensive application of molecular diagnostic techniques, it becomes possible to detect genetic distinctions between various types of renal neoplasm and discover new entities, otherwise misdiagnosed or diagnosed as unclassified RCC. Some tumors such as ALK rearrangement-associated RCC, MiT family translocation renal carcinomas, SDH-deficient renal cancer or FH-deficient RCC, are defined by their molecular characteristics. The most recent World Health Organization (WHO) classification of renal neoplasms account for more than 50 entities and provisional entities. New entities might be included in the upcoming WHO classification. The aim of this review is to summarise and discuss the newly acquired data and evidence on the clinical, pathological, molecular features and on the prognosis of new RCC entities, which will hopefully increase the awareness and the acceptance of these entities among clinicians and improve prognostication for individual patients.  相似文献   
9.
We investigated the occurrence and management of therapy‐related hematological disorders (tr‐HDs) in women with epithelial ovarian cancer (EOC) exposed to poly‐ADP‐ribose polymerase inhibitors (PARPi), after previous chemotherapy. We analyzed 130 consecutive EOC patients treated with PARPi at the European Institute of Oncology, Milan. In line with the literature, overall survival of the entire population was 37% at 5.5 years (89% were advanced stages). Cell blood counts were collected prior to start PARPi, at each new cycle and at monthly intervals. Patients displaying persistent and/or marked hematological abnormalities underwent bone marrow evaluation, with cytogenetic and molecular analysis. Nine patients (6,9%) developed tr‐HDs, after a median 22.8 months of PARPi exposure. Two patients died early and could not be treated. Two patients have no indication for active treatment and are presently under close hematological monitoring. Five patients underwent chemotherapy followed, in three cases, by allogeneic hematopoietic transplantation: three patients are in complete remission of their hematological and gynecological malignancies at 13, 19, and 25 months; the remaining two patients died due to progression of their hematological disease. We show the potential risk of hematological disorders in EOC patients treated with chemotherapy and prolonged PARPi therapy. In our series, tr‐HDs incidence was higher compared to recent reports in large series. Our observations suggest careful monitoring in order to conclusively define, on large series and prolonged follow‐up, the actual risk of tr‐HDs in patients under PARPi. Notably, prompt diagnosis of hematological abnormalities and appropriate management allow achievement of remission from severe hematological complications, at least in most patients.  相似文献   
10.
Mechanical intravascular hemolysis is frequently observed following procedures on heart valves and uncommonly observed in native valvular disease. In most cases, its severity is mild. Nevertheless, it can be clinically significant and even life threatening, requiring multiple blood transfusions and renal replacement therapy. This paper reviews the current knowledge on mechanical intravascular hemolysis in valvular disease, before and after correction, focusing on pathophysiology, approach to diagnosis, and impact of other hematological conditions on the resultant anemia. The importance of a multidisciplinary management is underscored. Laboratory data are provided about subclinical hemolysis that is commonly observed following the implantation of surgical and transcatheter valve prostheses and devices. Finally, clinical scenarios are reviewed and current medical and surgical treatments are discussed, including alternative options for inoperable patients.  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号