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排序方式: 共有1321条查询结果,搜索用时 31 毫秒
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Felicity Dewhurst Hannah Billett Lauri Simkiss Charlotte Bryan Julie Barnsley Max Charles Elizabeth Fleming Jennifer Grieve Sade Hacking Kate Howorth Amy Huggin Emily Kavanagh Rachel Kiltie Lucy Lowery Dene Miller Alex Nicholson Lucy Nicholson Ann Paxton Katherine Frew 《Journal of pain and symptom management》2021,61(5):e7-e12
ContextThe pandemic has substantially increased the workload of hospital palliative care providers, requiring them to be responsive and innovative despite limited information on the specific end of life care needs of patients with COVID-19. Multi-site data detailing clinical characteristics of patient deaths from large populations, managed by specialist and generalist palliative care providers are lacking.ObjectivesTo conduct a large multicenter study examining characteristics of COVID-19 hospital deaths and implications for care.MethodsA multi-center retrospective evaluation examined 434 COVID-19 deaths in 5 hospital trusts over the period March 23, 2020 to May 10, 2020.ResultsEighty three percent of patients were over 70.32% were admitted from care homes. Diagnostic timing indicated over 90% of those who died contracted the virus in the community. Dying was recognized in over 90% of patients, with the possibility of dying being identified less than 48 hours from admission for a third. In over a quarter, death occurred less than 24 hours later. Patients who were recognized to be dying more than 72 hours prior to death were most likely to have access to medication for symptom control.ConclusionThis large multicenter study comprehensively describes COVID-19 deaths throughout the hospital setting. Clinicians are alert to and diagnose dying appropriately in most patients. Outcomes could be improved by advance care planning to establish preferences, including whether hospital admission is desirable, and alongside this, support the prompt use of anticipatory subcutaneous medications and syringe drivers if needed. Finally, rapid discharges and direct hospice admissions could better utilize hospice beds and improve care. 相似文献
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Felicity M. Bright Georgia K. Chaseling Ollie Jay Nathan B. Morris 《Journal of Science and Medicine in Sport》2019,22(3):371-377
Objectives
To investigate whether the exercise performance benefits with neck cooling in the heat are attributable to neck-specific cooling, general body cooling, a cooler site-specific thermal perception or a combination of the above.Design
Counter-balanced crossover design.Methods
Twelve healthy participants cycled in the heat (34 °C, 30% relative humidity), at a power output (PO) self-selected to maintain a fixed rating of perceived exertion (RPE) of 16. Each participant underwent four experimental trials: no cooling (CON), neck cooling (NEC), abdominal cooling (ABD), or neck cooling with menthol (MEN). Participants cycled for 90 min or until their workload reduced by <70% of their initial PO. Changes in PO, rectal temperature (Tre), mean skin temperature (Tsk), whole-body thermal sensation (TSwb) and thermal sensation of the neck (TSneck) were recorded throughout.Results
The mean reduction in PO throughout exercise was similar (p = 0.431) for CON (175 ± 10 W), NEC (176 ±12 W), ABD (172 ± 13 W) and MEN (174 ± 12 W). The ΔTre at the end of exercise was similar (p = 0.874) for CON (0.83 ± 0.5 °C), NEC (0.85 ± 0.5 °C), ABD (0.82 ± 0.5 °C) and MEN (0.81 ± 0.5 °C). TSwb was cooler (p < 0.013) in MEN (125 ± 8 mm) compared to CON (146 ± 19 mm), NEC (135 ± 11 mm) and ABD (141 ± 16 mm).Conclusions
No differences in exercise performance or thermal strain were observed in any of the cooling trials compared to the CON trial, despite significantly cooler TSwb values in the MEN and NEC trials compared to the CON trial. These findings differ from previous observations and highlight that the benefit of neck cooling may be situation dependent. 相似文献4.
Standardised virtual fracture clinic management of Achilles tendon ruptures is safe and reproducible
Alastair Robertson Charles Godavitarne Simon Bellringer Enis Guryel Felicity Auld Lucy Cassidy James Gibbs 《Foot and Ankle Surgery》2019,25(6):782-784
BackgroundTraditional fracture clinics are some of the busiest clinics in a hospital, often with significant patient waiting times and delays. The use of virtual fracture clinic (VFC) for the management of certain injuries to reduce the workload on the traditional fracture clinic, in addition to reducing costs is growing in popularity. The tendoachilles is the most frequently ruptured tendon in the body but despite this, management remains a keenly debated topic.MethodsAll adult patients referred to the VFC with an actual or suspected Achilles tendon rupture were identified between January 2015 to October 2017.ResultsThis study found that patient with and acute achilles tendon ruptures managed according to a standardised VFC protocol had a re-rupture rate of 3.82%.ConclusionsOne of the advantages of a VFC model that is standardised, initiated in the ED, is that it has no variation in outcome seen in our patient group. 相似文献
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Jennifer L. Beebe-Dimmer MPH PhD Julie J. Ruterbusch MPH Felicity W. K. Harper PhD Tara M. Baird MS David G. Finlay BS Andrew G. Rundle MPH DrPH Stephanie S. Pandolfi PhD Theresa A. Hastert PhD Kendra L. Schwartz MD Gerold Bepler MD Michael S. Simon MD Julia Mantey MPH Judy Abrams PhD Teri L. Albrecht PhD Ann G. Schwartz MPH PhD 《Cancer》2020,126(9):1987-1994
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Comparative analgesic efficacy of pregabalin administered according to either a prevention protocol or an intervention protocol in rats with cisplatin‐induced peripheral neuropathy 下载免费PDF全文
Felicity Y Han Andy Kuo Janet R Nicholson Laura Corradinni Maree T Smith 《Clinical and experimental pharmacology & physiology》2018,45(10):1067-1075
Chemotherapy‐induced peripheral neuropathy (CIPN) is a type of peripheral neuropathic pain that may be dose‐limiting in patients administered potentially curative cancer chemotherapy dosing regimens. In cancer survivors, persistent CIPN adversely affects patient quality of life and so adjuvant drugs (anticonvulsants eg pregabalin or antidepressants eg amitriptyline) are recommended for the relief of CIPN. However, most studies in rodent models of CIPN involve administration of single bolus doses of adjuvant drugs to assess pain‐relieving efficacy. Hence this study was designed to assess the efficacy of pregabalin administered to CIPN‐rats according to either a prevention or an intervention protocol. Groups of male Sprague‐Dawley rats received four single intraperitoneal bolus doses of cisplatin at 3 mg/kg at once‐weekly intervals to induce CIPN. For the prevention protocol, oral pregabalin (or vehicle) was administered to CIPN‐rats once‐daily for 21 consecutive days from day 0 to day 20 inclusive. For the intervention protocol, oral pregabalin was administered once‐daily for 21 consecutive days from day 28 to day 48, inclusive. Mechanical allodynia and mechanical hyperalgesia in the bilateral hindpaws were assessed just prior to each dose of cisplatin and at least once weekly until study completion (day 27, prevention protocol; or day 48, intervention protocol). Mechanical allodynia and mechanical hyperalgesia were also determined at the time of peak effect at about 2 hours post pregabalin/vehicle administration, once weekly until study completion. For the prevention protocol in CIPN‐rats, pregabalin alleviated mechanical hyperalgesia but not mechanical allodynia. For the intervention protocol, pregabalin alleviated both mechanical allodynia and mechanical hyperalgesia in the hindpaws. 相似文献