全文获取类型
收费全文 | 2055篇 |
免费 | 139篇 |
国内免费 | 73篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 66篇 |
妇产科学 | 29篇 |
基础医学 | 266篇 |
口腔科学 | 36篇 |
临床医学 | 320篇 |
内科学 | 491篇 |
皮肤病学 | 63篇 |
神经病学 | 88篇 |
特种医学 | 279篇 |
外科学 | 181篇 |
综合类 | 42篇 |
一般理论 | 1篇 |
预防医学 | 136篇 |
眼科学 | 36篇 |
药学 | 110篇 |
中国医学 | 5篇 |
肿瘤学 | 113篇 |
出版年
2021年 | 12篇 |
2020年 | 16篇 |
2019年 | 13篇 |
2018年 | 21篇 |
2017年 | 15篇 |
2016年 | 17篇 |
2015年 | 24篇 |
2014年 | 40篇 |
2013年 | 47篇 |
2012年 | 77篇 |
2011年 | 88篇 |
2010年 | 70篇 |
2009年 | 85篇 |
2008年 | 87篇 |
2007年 | 111篇 |
2006年 | 65篇 |
2005年 | 74篇 |
2004年 | 61篇 |
2003年 | 43篇 |
2002年 | 53篇 |
2001年 | 60篇 |
2000年 | 68篇 |
1999年 | 37篇 |
1998年 | 95篇 |
1997年 | 80篇 |
1996年 | 65篇 |
1995年 | 57篇 |
1994年 | 48篇 |
1993年 | 52篇 |
1992年 | 45篇 |
1991年 | 38篇 |
1990年 | 44篇 |
1989年 | 66篇 |
1988年 | 53篇 |
1987年 | 43篇 |
1986年 | 37篇 |
1985年 | 38篇 |
1984年 | 33篇 |
1983年 | 20篇 |
1982年 | 25篇 |
1981年 | 13篇 |
1980年 | 21篇 |
1979年 | 21篇 |
1978年 | 17篇 |
1977年 | 32篇 |
1976年 | 25篇 |
1975年 | 20篇 |
1974年 | 9篇 |
1973年 | 9篇 |
1970年 | 12篇 |
排序方式: 共有2267条查询结果,搜索用时 15 毫秒
1.
Guang Hua Yim Ojas Jyoti Singh Pujji Indervir Singh Bharj Edmund Farrar 《Burns : journal of the International Society for Burn Injuries》2019,45(8):1783-1791
IntroductionThe prevalence of obese adults is rising across the world with a tripling of rates since 1975. The resuscitation of large burns in obese patients brings unique challenges leading some to advocate the use of a bariatric specific burn chart.AimsWe sought to determine whether bariatric burn specific charts can better estimate burn percentage to prevent under resuscitation. We also reviewed the impact of obesity upon the length of hospital stay, morbidity and mortality at our institution.MethodsA retrospective case note review, of patients identified from the prospective International Burns Injury Database (iBID), was undertaken of patients’ ≥18 years of age with burns ≥15% of their total body surface area.ResultsThere were 79 overweight and 53 bariatric patients from a total of 232 patients identified. There was no statistical difference in burn percentage or fluid input estimation between the Lund & Browder and Neaman charts. Complications were seen in 51% of the normal weight patients. Obese patients had a similar incidence of death (24%) compared to the normal weight group (26%). The class I obese had the lowest complication rate at 28% and lowest mortality rate at 11%.ConclusionsBariatric specific charts did not demonstrate any benefits in optimising bariatric resuscitation. There appears to be a ‘physiological benefit’ in the class I obese who sustained burns undergoing resuscitation. 相似文献
2.
3.
Phung Duc Thuan Nguyen Thuy Nha Ca Pham Van Toi Nguyen Thanh Thuy Nhien Ngo Viet Thanh Nguyen Duc Anh Nguyen Hoan Phu Cao Quang Thai Le Hong Thai Nhu Thi Hoa Le Thanh Dong Mai Anh Loi Do Hung Son Tran Tinh Ngoc Khanh Christiane Dolecek Ho Thi Nhan Marcel Wolbers Guy Thwaites Jeremy Farrar Nicholas J. White Tran Tinh Hien 《The American journal of tropical medicine and hygiene》2016,94(4):879-885
A total of 128 Vietnamese patients with symptomatic Plasmodium vivax mono-infections were enrolled in a prospective, open-label, randomized trial to receive either chloroquine or dihydroartemisinin–piperaquine (DHA-PPQ). The proportions of patients with adequate clinical and parasitological responses were 47% in the chloroquine arm (31 of 65 patients) and 66% in the DHA-PPQ arm (42 of 63 patients) in the Kaplan–Meier intention-to-treat analysis (absolute difference 19%, 95% confidence interval = 0–37%), thus establishing non-inferiority of DHA-PPQ. Fever clearance time (median 24 versus 12 hours, P = 0.02), parasite clearance time (median 36 versus 18 hours, P < 0.001), and parasite clearance half-life (mean 3.98 versus 1.80 hours, P < 0.001) were all significantly shorter in the DHA-PPQ arm. All cases of recurrent parasitemia in the chloroquine arm occurred from day 33 onward, with corresponding whole blood chloroquine concentration lower than 100 ng/mL in all patients. Chloroquine thus remains efficacious for the treatment of P. vivax malaria in southern Vietnam, but DHA-PPQ provides more rapid symptomatic and parasitological recovery. 相似文献
4.
Charlotte W Ockeloen Marjolein H Willemsen Sonja de Munnik Bregje WM van Bon Nicole de Leeuw Aad Verrips Sarina G Kant Elizabeth A Jones Han G Brunner Rosa LE van Loon Eric EJ Smeets Mieke M van Haelst Gijs van Haaften Ann Nordgren Helena Malmgren Giedre Grigelioniene Sascha Vermeer Pedro Louro Lina Ramos Thomas JJ Maal Celeste C van Heumen Helger G Yntema Carine EL Carels Tjitske Kleefstra 《European journal of human genetics : EJHG》2015,23(9):1270-1185
Loss-of-function variants in ANKRD11 were identified as the cause of KBG syndrome, an autosomal dominant syndrome with specific dental, neurobehavioural, craniofacial and skeletal anomalies. We present the largest cohort of KBG syndrome cases confirmed by ANKRD11 variants reported so far, consisting of 20 patients from 13 families. Sixteen patients were molecularly diagnosed by Sanger sequencing of ANKRD11, one familial case and three sporadic patients were diagnosed through whole-exome sequencing and one patient was identified through genomewide array analysis. All patients were evaluated by a clinical geneticist. Detailed orofacial phenotyping, including orthodontic evaluation, intra-oral photographs and orthopantomograms, was performed in 10 patients and revealed besides the hallmark feature of macrodontia of central upper incisors, several additional dental anomalies as oligodontia, talon cusps and macrodontia of other teeth. Three-dimensional (3D) stereophotogrammetry was performed in 14 patients and 3D analysis of patients compared with controls showed consistent facial dysmorphisms comprising a bulbous nasal tip, upturned nose with a broad base and a round or triangular face. Many patients exhibited neurobehavioural problems, such as autism spectrum disorder or hyperactivity. One-third of patients presented with (conductive) hearing loss. Congenital heart defects, velopharyngeal insufficiency and hip anomalies were less frequent. On the basis of our observations, we recommend cardiac assessment in children and regular hearing tests in all individuals with a molecular diagnosis of KBG syndrome. As ANKRD11 is a relatively common gene in which sequence variants have been identified in individuals with neurodevelopmental disorders, it seems an important contributor to the aetiology of both sporadic and familial cases. 相似文献
5.
6.
7.
A Mocroft B Neesgard R Zangerle A Rieger A Castagna V Spagnuolo A Antinori FC Lampe M Youle JJ Vehreschild C Mussini V Borghi J Begovac C Duvivier HF Gunthard A Rauch J Tiraboschi N Chkhartishvili N Bolokadze F Wit JC Wasmuth S De Wit C Necsoi C Pradier V Svedhem C Stephan K Petoumenos H Garges F Rogatto L Peters L Ryom 《HIV medicine》2020,21(9):599-606
8.
9.
Regina K. Rowe David M. Pyle J. David Farrar Michelle A. Gill 《European journal of immunology》2020,50(10):1550-1559
Rhinovirus (RV) infections are linked to the development and exacerbation of allergic diseases including allergic asthma. IgE, another contributor to atopic disease pathogenesis, has been shown to regulate DC antiviral functions and influence T cell priming by monocytes. We previously demonstrated that IgE-mediated stimulation of monocytes alters multiple cellular functions including cytokine secretion, phagocytosis, and influenza-induced Th1 development. In this study, we investigate the effects of IgE-mediated stimulation on monocyte-driven, RV-induced T cell development utilizing primary human monocyte-T cell co-cultures. We demonstrate that IgE crosslinking of RV-exposed monocytes enhances monocyte-driven Th2 differentiation. This increase in RV-induced Th2 development was regulated by IgE-mediated inhibition of virus-induced type I IFN and induction of IL-10. These findings suggest an additional mechanism by which two clinically significant risk factors for allergic disease exacerbations—IgE-mediated stimulation and rhinovirus infection—may synergistically promote Th2 differentiation and allergic inflammation. 相似文献