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排序方式: 共有5611条查询结果,搜索用时 15 毫秒
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Orazio Palmieri Tommaso Mazza Gabrio Bassotti Antonio Merla Salvatore Tolone Tommaso Biagini Antonello Cuttitta Fabrizio Bossa Giuseppina Martino Tiziana Latiano Giuseppe Corritore Domenica Gioffreda Orazio Palumbo Massimo Carella Anna Panza Angelo Andriulli Anna Latiano 《Neurogastroenterology and motility》2020,32(3)
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Giacomo Strigini Michele Rendina Matteo Ghiara Fabrizio Quattrini Laura Ghidoni Valeria Burgio Pietro Maniscalco Francesco Benazzo 《Injury》2019,50(2):382-385
Introduction
In this retrospective study we have analyzed a consecutive series of patients affected by isolated radial head Mason III fractures and treated with bone resection or prosthesis.Patients and methods
This study includes 24 patients affected by fractures mentioned above and treated between July 2009 and November 2015.15 patients (average age 48 y.o.) have been treated with prosthesis. The remaining 9 (average age 573) have been treated with a capitellectomy instead.From a clinical point of view, we have evaluated the patients according to main performance indicators such as range of motion, pain, instability and Mayo Elbow Performance Score as parameters.Results
We have found similar results in both group, with an average MEPS value of 95 in the prosthesis group and 966 in the radial head resection group.The range of motion was similar too: between 1,3° and 1203° in the first group and between 4,4° and 120° in the second one. No significant complication has detected in any patient.Discussion
According to most recent literature, it is not precisely defined how to treat isolated Mason III fractures, contrary to what is defined in more complex pattern, in which prosthesis are now evaluated as the best indication.Due to radial head limited contribution to elbow stability, in absence of other bony or ligamentous lesions both capitellectomy and prosthesis can be good treatment in this kind of fracture.Conclusion
According to our experience and to the most recent literature, we recommend prosthesis in patient younger than 50 y.o., high demanding or manual worker, while in other cases we think that radial head resection can be the treatment of choice. 相似文献5.
Vladan Milosevic Joanna Kopecka Iris C. Salaroglio Roberta Libener Francesca Napoli Stefania Izzo Sara Orecchia Preeta Ananthanarayanan Paolo Bironzo Federica Grosso Fabrizio Tabbò Valentina Comunanza Teodora Alexa-Stratulat Federico Bussolino Luisella Righi Silvia Novello Giorgio V. Scagliotti Chiara Riganti 《International journal of cancer. Journal international du cancer》2020,146(1):192-207
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Mario Vaccaro MD PhD Claudio Guarneri MD Fabrizio Guarneri MD PhD Maria Lentini MD Serafinella P. Cannavò MD 《Pediatric dermatology》2020,37(6):1207-1209
We describe a case of pretibial dystrophic epidermolysis bullosa in a 5-year-old girl, her mother, and maternal great aunt. All subjects had trauma-induced blisters and erosions, with scarring, on the knees and lower legs, and nail dystrophy of variable severity. Genetic analysis in all three patients showed a 6849del18 mutation in the COL7A1 gene, causing the production of shortened collagen VII polypeptides and resulting in a mild phenotype, with localized acral blisters and nail involvement. 相似文献
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Lunetta Christian Moglia Cristina Lizio Andrea Caponnetto Claudia Dubbioso Raffaele Giannini Fabio Matà Sabrina Mazzini Letizia Sabatelli Mario Siciliano Gabriele Simone Isabella Laura Sorarù Gianni Toriello Antonella Trojsi Francesca Vedovello Marcella D’Ovidio Fabrizio Filippi Massimo Calvo Andrea 《Journal of neurology》2020,267(11):3258-3267
Journal of Neurology - The aim of the study is to analyze the ALS disease progression and respiratory function of Italian patients treated with edaravone (EVN), as well as the adherence to, and the... 相似文献
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Alyson L. Essex Joshua R. Huot Padmini Deosthale Alison Wagner Jorge Figueras Azaria Davis John Damrath Fabrizio Pin Joseph Wallace Andrea Bonetto Lilian I. Plotkin 《Journal of bone and mineral research》2022,37(7):1366-1381
Previous studies proposed the Triggering Receptor Expressed on Myeloid Cells 2 (TREM2), a receptor expressed in myeloid cells including microglia in brain and osteoclasts in bone, as a link between brain and bone disease. The TREM2 R47H variant is a known risk factor for Alzheimer's disease (AD), the most common form of dementia. To investigate whether altered TREM2 signaling could contribute to bone and skeletal muscle loss, independently of central nervous system defects, we used mice globally hemizygous for the TREM2 R47H variant (TREM2R47H/+), which do not exhibit AD pathology, and wild-type (WT) littermate control mice. Dxa/Piximus showed bone loss in female TREM2R47H/+ animals between 4 and 13 months of age and reduced cancellous and cortical bone (measured by micro-computed tomography [μCT]) at 13 months, which stalled out by 20 months of age. In addition, they exhibited decreased femoral biomechanical properties measured by three-point bending at 13 months of age, but not at 4 or 20 months. Male TREM2R47H/+ animals had decreased trabecular bone geometry but increased ultimate strain and failure force at 20 months of age versus WT. Only male TREM2R47H/+ osteoclasts differentiated more ex vivo after 7 days with receptor activator of nuclear factor κB ligand (RANKL)/macrophage colony-stimulating factor (M-CSF) compared to WT littermates. Yet, estrogen receptor alpha expression was higher in female and male TREM2R47H/+ osteoclasts compared to WT mice. However, female TREM2R47H/+ osteoclasts expressed less complement 3 (C3), an estrogen responsive element, and increased protein kinase B (Akt) activity, suggesting altered estrogen signaling in TREM2R47H/+ cells. Despite lower bone volume/strength in TREM2R47H/+ mice, skeletal muscle function measured by plantar flexion and muscle contractility was increased in 13-month-old female mutant mice. Overall, these data demonstrate that an AD-associated TREM2 variant can alter bone and skeletal muscle strength in a sex-dimorphic manner independent of central neuropathology, potentially mediated through changes in osteoclastic intracellular signaling. © 2022 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR). 相似文献