Sex-biased autophagy as a potential mechanism mediating sex differences in ischemic stroke outcome

Stroke is the second leading cause of death and a major cause of disability worldwide, and biological sex is an important determining factor in stroke incidence and pathology. From childhood through adulthood, men have a higher incidence of stroke compared with women. Abundant research has confirmed the beneficial effects of estrogen in experimental ischemic stroke but genetic factors such as the X-chromosome complement can also play an important role in determining sex differences in stroke. Au...     

Gangliosides in nervous system development,regeneration, and pathologies

Gangliosides, sialic acid-containing sphingolipids, are major constituents of neuronal membranes. According to the number of sialic acids and the structure of the oligosaccharide chain, gangliosides can be classified as simple or complex and grouped in different ganglio-series. Hundreds of gangliosides have been identified in vertebrate cells, with different expression patterns during development and related to several physiological processes, especially in the nervous system. While GD3 and its ...     

基于实体瘤疗效评价标准1.1版(RECIST1.1)中的体积阈值:肝转移瘤治疗效果评估

正摘要目的根据临床经验确定肝转移瘤的体积阈值,以评估肝转移瘤的治疗效果及其进展,并使其与线性RECIST阈值保持一致。方法选取最初参加多中心临床Ⅲ期试验的     

可疑儿童急性阑尾炎的首选MRI诊断评估

正摘要随着腹部MRI技术的进步,无需静脉注射或口服对比剂即可实现快速、自由呼吸成像。对于疑似阑尾炎,MRI作为首选成像方法尚未有相关研究。目的探讨MRI作为可     

X线平片上未见膝关节骨性关节炎的中老年人半月板体部突出及软骨覆盖的情况

正摘要目的探讨X线平片未见胫股骨性关节炎(KL评分为0)的中老年人膝关节半月板体部突出和覆盖软骨的MR影像及其相关因素。方法纳入718例X线平片未见胫     

CT影像评估不透射线药物洗脱微球经动脉化学栓塞术后药物剂量在兔肿瘤模型中的分布

正摘要目的探讨在兔肿瘤模型中用不透射线的药物洗脱微球(DEB)行经动脉化学栓塞术(TACE)后,CT影像中微球的位置和衰减情况与进入肝脏的药物含量和分布之间的     

在MRI和CT检查中含铜避孕器的风险评估:宫内植入避孕器对女性的影响

正摘要目的评估宫内植入含铜避孕器(IUD)者在MRI和CT检查中的风险。方法本实验中建立了一个适合本项研究的仿真体模。选取7种不同类型的含铜IUD,在1.5 T和     

From regenerative strategies to pharmacological approaches:can we fine-tune treatment for Parkinson's disease?

Parkinson's disease is the second most prevalent neurodegenerative disorder worldwide.Clinically,it is characterized by severe motor complications caused by progressive degeneration of dopaminergic neurons.Current treatment is focused on mitigating the symptoms through the administration of levodopa,rather than on preventing dopaminergic neuronal damage.Therefore,the use and development of neuroprotective/disease-modifying strategies is an absolute need that can lead to promising gains on translational research of Parkinson's disease.For instance,N-acetylcysteine,a natural compound with strong antioxidant effects,has been shown to modulate oxidative stress,preventing dopamine-induced cell death.Despite the evidence of neuroprotective and modulatory effects of this drug,as far as we know,it does not induce per se any regenerative process.Therefore,it would be of interest to combine the latter with innovative therapies that induce dopaminergic neurons repair or even differentiation,as stem cell-based strategies.Stem cells secretome has been proposed as a promising therapeutic approach for Parkinson's disease,given its ability to modulate cell viability/preservation of dopaminergic neurons.Such approach represents a shift in the paradigm,showing that cell-transplantation free therapies based on the use of stem cells secretome may represent a potential alternative for regenerative medicine of Parkinson's disease.Thus,in this review,we address the current understanding of the potential combination of stem cell free-based strategies and neuroprotective/disease-modifying strategies as a new paradigm for the treatment of central nervous system neurodegenerative diseases,like Parkinson's disease.     

慢性丙型肝炎患者直接抗病毒治疗后的临床结局——一项前瞻性队列研究

<正>【据《Lancet》2019年2月报道】题:慢性丙型肝炎患者直接抗病毒治疗后的临床结局——一项前瞻性队列研究(作者Carrat F等)虽然直接抗病毒药物已广泛用于慢性HCV感染者的治疗,但其临床效果尚未得到充分报道。来自法国皮埃尔·路易斯流行病学和公共卫生研究所的Carrat等比较了法国国家艾滋病研究署(ANRS) CO22 Hepather队列中直接抗病