全文获取类型
收费全文 | 202696篇 |
免费 | 4410篇 |
国内免费 | 505篇 |
专业分类
耳鼻咽喉 | 2923篇 |
儿科学 | 7635篇 |
妇产科学 | 5895篇 |
基础医学 | 26078篇 |
口腔科学 | 6004篇 |
临床医学 | 15609篇 |
内科学 | 36913篇 |
皮肤病学 | 4602篇 |
神经病学 | 12268篇 |
特种医学 | 11056篇 |
外国民族医学 | 97篇 |
外科学 | 30883篇 |
综合类 | 1130篇 |
一般理论 | 2篇 |
预防医学 | 16525篇 |
眼科学 | 4353篇 |
药学 | 13995篇 |
2篇 | |
中国医学 | 143篇 |
肿瘤学 | 11498篇 |
出版年
2018年 | 3687篇 |
2017年 | 3988篇 |
2016年 | 3358篇 |
2015年 | 5041篇 |
2014年 | 4511篇 |
2013年 | 3612篇 |
2012年 | 10231篇 |
2011年 | 5167篇 |
2010年 | 2504篇 |
2009年 | 4111篇 |
2008年 | 2449篇 |
2007年 | 3200篇 |
2006年 | 3502篇 |
2005年 | 11611篇 |
2004年 | 13067篇 |
2003年 | 8641篇 |
2002年 | 3826篇 |
2001年 | 4505篇 |
2000年 | 1871篇 |
1999年 | 6054篇 |
1998年 | 626篇 |
1995年 | 458篇 |
1992年 | 7010篇 |
1991年 | 7240篇 |
1990年 | 7483篇 |
1989年 | 7098篇 |
1988年 | 6601篇 |
1987年 | 6361篇 |
1986年 | 6067篇 |
1985年 | 5347篇 |
1984年 | 3659篇 |
1983年 | 2971篇 |
1982年 | 1036篇 |
1981年 | 790篇 |
1980年 | 882篇 |
1979年 | 3879篇 |
1978年 | 2396篇 |
1977年 | 1811篇 |
1976年 | 1580篇 |
1975年 | 2486篇 |
1974年 | 3126篇 |
1973年 | 2758篇 |
1972年 | 2774篇 |
1971年 | 2768篇 |
1970年 | 2580篇 |
1969年 | 2488篇 |
1968年 | 2261篇 |
1967年 | 2178篇 |
1966年 | 1918篇 |
1965年 | 1141篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Buket Bakan Fatih Oltulu Yeliz Y?ld?r?m Altu? Yava?o?lu Sinan Akg?l Nefise ülkü Karabay Yava?o?lu 《Arhiv za higijenu rada i toksikologiju》2023,74(3):207
The aim of this safety study in mice was to determine in vivo toxicity and biodistribution potential of a single and multiple doses of L-glutamic acid-g-p(HEMA) polymeric nanoparticles as a drug delivery system. The single dose did not cause any lethal effect, and its acute oral LD50 was >2.000 mg/kg body weight (bw). Multiple doses (25, 50, or 100 mg/kg bw) given over 28 days resulted in no significant differences in body and relative organ weights compared to control. These results are supported by biochemical and histological findings. Moreover, nanoparticle exposure did not result in statistically significant differences in micronucleus counts in bone marrow cells compared to control. Nanoparticle distribution was time-dependent, and they reached the organs and even bone marrow by hour 6, as established by ex vivo imaging with the IVIS® spectrum imaging system. In conclusion, L-glutamic acid-g-p(HEMA) polymeric nanoparticles appear biocompatible and have a potential use as a drug delivery system.KEY WORDS: biocompatibility, blood biochemistry, genotoxicity, histology, in vivo toxicity, micronucleus test, polymers 相似文献
2.
3.
4.
Kensuke Kudou Hiroshi Saeki Yuichiro Nakashima Shun Sasaki Tomoko Jogo Kosuke Hirose Qingjiang Hu Yasuo Tsuda Koichi Kimura Ryota Nakanishi Nobuhide Kubo Koji Ando Eiji Oki Tetsuo Ikeda Yoshihiko Maehara 《American journal of surgery》2019,217(4):757-763
Background
There were few studies assessed the postoperative sarcopenia in patients with cancers. The objective of present study was to assess whether postoperative development of sarcopenia could predict a poor prognosis in patients with adenocarcinoma of esophagogastric junction, (AEG) and upper gastric cancer (UGC).Methods
Patients with AEG and UGC who were judged as non-sarcopenic before surgery were reassessed the presence of postoperative development of sarcopenia 6 months after surgery. Patients were divided into the development group or non-development group, and clinicopathological factors and prognosis between these two groups were analyzed.Results
The 5-year overall survival rates were significantly poorer in the development group than non-development group (68.0% vs. 92.6%, P?=?0.0118). Multivariate analyses showed that postoperative development of sarcopenia was an independent prognostic factor for poor overall survival (P?=?0.0237).Conclusions
Postoperative development of sarcopenia was associated with a poor prognosis in patients with AEG and UGC. 相似文献5.
6.
Masaki Shiota Eiji Kashiwagi Tomohiko Murakami Ario Takeuchi Kenjiro Imada Junichi Inokuchi Katsunori Tatsugami Masatoshi Eto 《Urologic oncology》2019,37(3):180.e19-180.e24
Purpose
Currently, several therapeutic options for castration-resistant prostate cancer (CRPC) are available, for which predictive biomarkers have not been established. Therefore, we aimed to reveal the association between pretreatment serum testosterone level and antitumor outcomes when treated with androgen receptor axis-targeting agents and taxane chemotherapies for CRPC.Patients and methods
The present study included Japanese patients with metastatic prostate cancer whose serum testosterone levels during androgen-deprivation therapy were available. The antitumor outcomes when treated with enzalutamide, abiraterone, docetaxel, and cabazitaxel with clinicopathological parameters including serum testosterone levels during androgen-deprivation therapy, as well as prognoses including progression-free survival and overall survival, were examined.Results
Progression-free survival among men with higher serum testosterone level was superior to that among men with lower serum testosterone level when treated with enzalutamide. On the contrary, progression-free survival and overall survival among men with higher serum testosterone level were significantly inferior to those among men with lower serum testosterone level when treated with docetaxel and cabazitaxel, respectively.Conclusions
The present study indicated distinct prognostic values of serum testosterone level when treated with androgen receptor axis-targeting agent and taxane chemotherapy for CRPC, suggesting that serum testosterone level may be useful predictive biomarker to navigate the appropriate therapy in patients with CRPC. 相似文献7.
Takahiro Hosokawa Hiroaki Takahashi Yutaka Tanami Yumiko Sato Mayumi Hosokawa Eiji Oguma 《Journal of ultrasound in medicine》2019,38(2):533-538
Portal venous gas is occasionally encountered in children with intestinal pneumatosis, identified on real‐time ultrasound imaging as hyperechoic foci with quick movement. The origin of the portal venous gas can be identified by following the hyperechoic foci along the branches of the portal vein, providing an estimate of the location of intestinal pneumatosis. This approach may be useful for predicting the patient's prognosis. Our report describes 2 cases of portal venous gas while estimating the area of intestinal pneumatosis, which were evaluated with real‐time ultrasound. 相似文献
8.
<正>what is the rationale for immunotherapies in Parkinsonian syndromes(PS)? PS are neurodegenerative diseases which are clinically characterized by a hypokinetic phenotype in combination with additional motor and non-motor symptoms. One major patholog- 相似文献
9.
10.
Ota Yumiko Takahari Daisuke Suzuki Takeshi Osumi Hiroki Nakayama Izuma Oki Akira Wakatsuki Takeru Ichimura Takashi Ogura Mariko Shinozaki Eiji Suenaga Mitsukuni Chin Keisho Yamaguchi Kensei 《Cancer chemotherapy and pharmacology》2020,85(2):265-272
Cancer Chemotherapy and Pharmacology - In the ATTRACTION-2 trial, nivolumab significantly improved the survival of advanced gastric cancer patients. The pretreatment neutrophil-to-lymphocyte ratio... 相似文献