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1.
Pandey Manisha Choudhury Hira Vijayagomaran Prathiba A/P Lian Pauline Ng Poh Ning Tan Jing Wai Ng Zing Xian-Zhuang Ng Le Er Chong Rahmah Nur Suraiza Nabila Kamaruzzaman Nur Dayana Binti Mayuren Jayashree Candasamy Mayuren Gorain Bapi Chawla Pooja A. Amin Mohd Cairul Iqbal Mohd 《Pharmaceutical research》2022,39(6):1115-1134
Pharmaceutical Research - Cancer is associated with a comprehensive burden that significantly affects patient’s quality of life. Even though patients’ disease condition is improving... 相似文献
2.
Rozhkov V. P. Trifonov M. I. Soroko S. I. 《Neuroscience and behavioral physiology》2022,52(3):383-394
Neuroscience and Behavioral Physiology - We present here results from analysis of the formation of brain bioelectrical activity in children and adolescents living in the northern region of Russia... 相似文献
3.
Richardson Matthew L. Guérit François Gransier Robin Wouters Jan Carlyon Robert P. Middlebrooks John C. 《Journal of the Association for Research in Otolaryngology》2022,23(4):491-512
Journal of the Association for Research in Otolaryngology - Cochlear implant (CI) users show limited sensitivity to the temporal pitch conveyed by electric stimulation, contributing to impaired... 相似文献
4.
Biniam Kidane MD MSc Ian J. Gerard MD PhD Jonathan Spicer MD PhD Julian O. Kim MD MSc BEng Pierre O. Fiset MD PhD Paul Wawryko MD Matthew J. Cecchini MD PhD Richard Inculet MD Bassam Abdulkarim MD PhD Dalilah Fortin MD Mehdi Qiabi MD MSc Gefei Qing MD Stephanie Enns BSc Bashir Bashir MBBS James Tankel MD Elliot Wakeam MD Andrew Warner MSc Neil Kopek MD Brian P. Yaremko MD MSc PEng George B. Rodrigues MD PhD Joanna M. Laba MD Melody Qu MD MPH Richard A. Malthaner MD MSc David A. Palma MD PhD 《Cancer》2023,129(18):2798-2807
Background
During coronavirus disease 2019 (COVID-19)–related operating room closures, some multidisciplinary thoracic oncology teams adopted a paradigm of stereotactic ablative radiotherapy (SABR) as a bridge to surgery, an approach called SABR-BRIDGE. This study presents the preliminary surgical and pathological results.Methods
Eligible participants from four institutions (three in Canada and one in the United States) had early-stage presumed or biopsy-proven lung malignancy that would normally be surgically resected. SABR was delivered using standard institutional guidelines, with surgery >3 months following SABR with standardized pathologic assessment. Pathological complete response (pCR) was defined as absence of viable cancer. Major pathologic response (MPR) was defined as ≤10% viable tissue.Results
Seventy-two patients underwent SABR. Most common SABR regimens were 34 Gy/1 (29%, n = 21), 48 Gy/3–4 (26%, n = 19), and 50/55 Gy/5 (22%, n = 16). SABR was well-tolerated, with one grade 5 toxicity (death 10 days after SABR with COVID-19) and five grade 2–3 toxicities. Following SABR, 26 patients underwent resection thus far (13 pending surgery). Median time-to-surgery was 4.5 months post-SABR (range, 2–17.5 months). Surgery was reported as being more difficult because of SABR in 38% (n = 10) of cases. Thirteen patients (50%) had pCR and 19 (73%) had MPR. Rates of pCR trended higher in patients operated on at earlier time points (75% if within 3 months, 50% if 3–6 months, and 33% if ≥6 months; p = .069). In the exploratory best-case scenario analysis, pCR rate does not exceed 82%.Conclusions
The SABR-BRIDGE approach allowed for delivery of treatment during a period of operating room closure and was well-tolerated. Even in the best-case scenario, pCR rate does not exceed 82%. 相似文献5.
6.
Dawson Luke P. Dinh Diem T. Stub Dion Ahern Susannah Bloom Jason E. Duffy Stephen J. Lefkovits Jeffrey Brennan Angela Reid Christopher M. Oqueli Ernesto 《Quality of life research》2022,31(8):2375-2385
Quality of Life Research - During the COVID-19 pandemic, widespread public health measures were implemented to control community transmission. The association between these measures and... 相似文献
7.
Ghemame M. Cathelineau C. Carsin-Nicol B. Eliat P.-A. Saint-Jalmes H. Ferré J.-C. Mouriaux F. 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2022,260(1):311-318
Graefe's Archive for Clinical and Experimental Ophthalmology - Ferromagnetic foreign bodies (FFB) present during magnetic resonance imaging (MRI) explorations can lead to tissue injury due to... 相似文献
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10.
Seah Davinia S. Tayob Nabihah Leone Jose Pablo Hu Jiani Yin Jun Hughes Melissa Scott Sarah M. Lederman Ruth I. Frank Elizabeth Sohl Jessica J. Stadler Zsofia K. Erick Timothy K. Peppercorn Jeffrey Winer Eric P. Silverman Stuart G. Come Steven E. Lin Nancy U. 《Breast cancer research and treatment》2022,192(1):201-210
Breast Cancer Research and Treatment - We sought to understand the attitudes of individuals with abnormal breast imaging findings prompting a diagnostic breast biopsy toward donation of blood,... 相似文献