全文获取类型
收费全文 | 8556篇 |
免费 | 710篇 |
国内免费 | 16篇 |
专业分类
耳鼻咽喉 | 63篇 |
儿科学 | 402篇 |
妇产科学 | 250篇 |
基础医学 | 997篇 |
口腔科学 | 161篇 |
临床医学 | 969篇 |
内科学 | 1497篇 |
皮肤病学 | 68篇 |
神经病学 | 733篇 |
特种医学 | 650篇 |
外科学 | 1320篇 |
综合类 | 196篇 |
一般理论 | 2篇 |
预防医学 | 742篇 |
眼科学 | 171篇 |
药学 | 561篇 |
1篇 | |
中国医学 | 4篇 |
肿瘤学 | 495篇 |
出版年
2021年 | 99篇 |
2020年 | 67篇 |
2019年 | 101篇 |
2018年 | 125篇 |
2017年 | 99篇 |
2016年 | 100篇 |
2015年 | 115篇 |
2014年 | 158篇 |
2013年 | 269篇 |
2012年 | 301篇 |
2011年 | 349篇 |
2010年 | 189篇 |
2009年 | 182篇 |
2008年 | 315篇 |
2007年 | 353篇 |
2006年 | 359篇 |
2005年 | 307篇 |
2004年 | 300篇 |
2003年 | 280篇 |
2002年 | 266篇 |
2001年 | 297篇 |
2000年 | 293篇 |
1999年 | 278篇 |
1998年 | 200篇 |
1997年 | 161篇 |
1996年 | 163篇 |
1995年 | 144篇 |
1994年 | 112篇 |
1993年 | 119篇 |
1992年 | 196篇 |
1991年 | 189篇 |
1990年 | 202篇 |
1989年 | 197篇 |
1988年 | 198篇 |
1987年 | 171篇 |
1986年 | 194篇 |
1985年 | 200篇 |
1984年 | 166篇 |
1983年 | 133篇 |
1982年 | 91篇 |
1981年 | 90篇 |
1980年 | 83篇 |
1979年 | 112篇 |
1978年 | 87篇 |
1977年 | 85篇 |
1976年 | 66篇 |
1975年 | 90篇 |
1974年 | 74篇 |
1973年 | 77篇 |
1972年 | 62篇 |
排序方式: 共有9282条查询结果,搜索用时 0 毫秒
1.
R. Jayasuriya V. Westley-Wise T. Dunn K. Nydam D. Jeffs 《Internal medicine journal》1993,23(6):672-677
Background: The management and follow-up of asthma patients presenting at Accident and Emergency (A&E) departments have mostly been studied in children's hospitals or specialised teaching hospitals. Aims: To study the adequacy of assessment, treatment and follow-up of patients presenting at A&E departments in non-teaching hospitals. Methods: A twenty-five per cent sample of presentations to A&E departments in all public hospitals in the Illawarra for one year was selected for a case note audit. Information on demographics, assessment, management and referral was extracted from the A&E case notes and medical records of cases with documentation of a final diagnosis of asthma. Chi square and Fischer's Exact tests were used for comparisons among hospitals. Results: Of 359 presentations with a final diagnosis of asthma, 88% were self referred and only 5% were first presentations. Objective measures of airways obstruction was not documented in 34% of admissions and 48% of nonadmissions. There was no documented follow-up in 28% of cases. The assessment and management of asthma in A&E was significantly poorer in smaller hospitals. Conclusion: Evidence of high use of A&E as a primary care facility by asthma patients was found in the study. There is a need to implement protocols to optimise assessment and treatment of asthma in smaller hospitals. (Aust NZ J Med 1993; 23: 672–677.). 相似文献
2.
Timothy J Halligan Nathan G Russell William J Dunn Steven J Caldroney Timothy B Skelton 《Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics》2005,100(6):688-692
Scurvy is a nondiscriminatory disease process resulting from a nutritional deficiency of ascorbic acid (vitamin C). The severe vitamin deficiency produces a breakdown in the cellular structure of the body. This case report describes a middle-age woman with a history of edema, bruising of the lower extremities, anemia, and severe periodontal disease. Her presentation and medical history are classic for the signs of scurvy. Scurvy is now only uncommonly seen in developed countries, but there are still vulnerable populations whose nutritional status can lead to scurvy. The aim of this report is to help the clinician identify and treat scurvy, a disease that was once feared for its high mortality but is now easily treatable, even in cases that have progressed to multiple organ dysfunction and failure. 相似文献
3.
D. W. Barnes, D. A. Sirbasku & G. H. Sato, (eds.): Cell culture methods for molecular and cell biology. P. M. Gootman (ed.): Developmental neurobiology of the autonomic nervous system. M. Sandler, C. Feuerstein, B. Scatton (eds.): Neurotransmitter interactions in the basal ganglia. Harry M. Zimmerman (ed). Progress in neuropathology. M. Yahr & K. J. Bergmann (eds.): Parkinson's disease. G. Bock & M. O'Connor (eds.): Selective neuronal death. H. Julia Hannay (ed.): Experimental techniques in human neuropsychology. D. Papakostopoulos, S. Butler, I. Martin (eds.): Clinical and experimental neuropsychophysiology J. C. Rothwell: Control of human voluntary movement. 相似文献
4.
5.
6.
Both cyproterone acetate (CPA) and the gonadotrophin-releasing hormone
agonist (GnRHa) have been shown to be effective for the treatment of
hirsutism. We wished to compare the effectiveness of CPA in two standard
doses with GnRHa and add-back therapy and to compare the length of
remission after these treatments. A total of 60 hirsute hyperandrogenic
women was assigned to the following treatment groups: CPA 2 mg with 35
microg of ethinylestradiol for 21 days each month (Diane group), CPA 50 mg,
days 5-15, and ethinylestradiol 50 microg, days 5-25, each month (CPA
group) or Decapeptyl 3.75 mg i.m. every 28 days with the addition of
conjugated oestrogen 0.625 mg, days 1-21, and medroxyprogesterone acetate
10 mg, days 12-21 (GnRHa group). Hirsutism was graded by the
Ferriman-Gallwey-Lorenzo (FGL) index and anagen hair shaft diameters and
serum luteinizing hormone (LH) and testosterone were assessed before and
every 3 months during and after treatment. All women were treated for 1
year with 1 year follow-up. At baseline hirsutism and endocrine patterns
were similar in all groups. After one year of treatment, hirsutism
decreased in all groups but the changes were greater (P <0.05) in the
CPA and GnRHa groups than in the Diane group. Serum LH and testosterone
were lowest in the GnRHa group. After withdrawal, hirsutism increased
rapidly in the Diane and CPA groups and after 6 months, FGL scores and hair
shaft diameters were similar to pretreatment values. In the GnRHa group,
hirsutism increased more gradually and after 1 year of withdrawal, FGL
scores and hair diameters were significantly (P <0.05) less than
pretreatment values. Serum LH and testosterone increased rapidly in all
three groups reaching pretreatment values by 6 months. These data suggest
equal efficacy of the GnRHa and the high dose CPA regimen for the treatment
of hirsutism in hyperandrogenic women. GnRHa with add-back treatment
appears to result in a longer remission of hirsutism in comparison with
CPA.
相似文献
7.
Maxillary sinusitis in adults: an evaluation of placebo-controlled double-blind trials 总被引:1,自引:0,他引:1
BACKGROUND: In general practice, acute sinusitis is frequently diagnosed
and treated with antibiotics. OBJECTIVE: This study aimed to determine the
evidence for the effectiveness of antibiotic treatment in acute maxillary
sinusitis in adults by assessing the methodological quality of
placebo-controlled double-blind randomized trials. METHOD: An evaluation by
four raters through a 35-item scoring-scale for internal and external
validity of all placebo-controlled double-blind randomized trials on acute
sinusitis found between January 1966 and July 1996. RESULTS: Eighty-five
trials were excluded because they were not placebo-controlled,
double-blind, randomized, or were carried out in patients with chronic
sinusitis or in children. The three remaining trials were performed in
different populations (one in general practice) between 1973 and 1978. Only
one study claimed superiority of antibiotic treatment. Different inclusion
criteria and major outcome measures were used by the authors. The
reliability of major outcome events was reported poorly or not at all and
in two studies outcome measures were clinically inappropriate. The studies
scored 30-62% of the maximum attainable score for internal validity and
10-20% for external validity. CONCLUSION: The effectiveness of antibiotic
treatment in acute maxillary sinusitis in a general practice population is
not based sufficiently on evidence.
相似文献
8.
L P Mercer S J Dodds M D Weber J D Dunn 《Nutrition (Burbank, Los Angeles County, Calif.)》1990,6(4):273-277
Feeding, a behavior regulated by the central nervous system (CNS), includes the acquisition of specific essential nutrients and the maintenance of energy balance. Modulation of feeding behavior is a normal part of survival, but certain pathological conditions interrupt or modify regulatory aspects of feeding, thereby leading to inappropriate intake. This review examines aspects of metabolism associated with the anorexia seen in animals suffering from protein-energy malnutrition (PEM). The main focus is the indispensable amino acid histidine (His), the biosynthetic precursor of the neurotransmitter histamine (HA). In kwashiorkor-like PEM, His is elevated in plasma and brain, whereas all other indispensable amino acids are decreased. The elevation of His in the brain is to concentrations five times normal. Because the rate of HA synthesis in the brain is a function of the His concentration, His elevation raises the possibility of a profound direct effect of CNS function. In children, PEM consistently produces the symptoms of depressed food intake, edema, growth failure, and psychomotor changes. One known central effect of HA is the stimulation of ACTH and corticosteroid release. Based on these observations, the hypothesis being examined is as follows: one component of the pathophysiological neuroregulation of food intake involved the His-induced variation of HA concentration in the hypothalamus and the subsequently altered neurochemical activity at the corticotropin-releasing factor (CRF) neurons o the paraventricular nucleus (PVN). 相似文献
9.
10.