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排序方式: 共有1845条查询结果,搜索用时 15 毫秒
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Dougherty Ryan J. Hoang Tina D. Launer Lenore J. Jacobs David R. Sidney Stephen Yaffe Kristine 《Brain imaging and behavior》2022,16(2):637-644
Brain Imaging and Behavior - The purpose of this study was to investigate whether long-term television viewing patterns, a common sedentary behavior, in early to mid-adulthood is associated with... 相似文献
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Chelsey S. Barrios Samantha Y. Jay Victoria C. Smith Candice A. Alfano Lea R. Dougherty 《Journal of clinical child and adolescent psychology》2018,47(3):382-396
Little research has examined the processes underlying children’s persistent sleep problems and links with later psychopathology. The current study examined the stability of parent–child sleep interactions as assessed with the parent-reported Parent–Child Sleep Interactions Scale (PSIS) and examined whether sleep interactions in preschool-age children predict sleep problems and psychiatric symptoms later in childhood. Participants included 108 preschool-age children (50% female) and their parents. Parents completed the PSIS when children were 3–5 years (T1) and again when they were 6–9 years (T2). The PSIS includes three subscales—Sleep Reinforcement (reassurance of child sleep behaviors), Sleep Conflict (parent–child conflict at bedtime), Sleep Dependence (difficulty going to sleep without parent)—and a total score. Higher scores indicate more problematic bedtime interactions. Children’s sleep problems and psychiatric symptoms at T1 and T2 were assessed with a clinical interview. PSIS scores were moderately stable from T1 to T2, and the factor structure of the PSIS remained relatively consistent over time. Higher total PSIS scores at T1 predicted increases in children’s sleep problems at T2. Higher PSIS Sleep Conflict scores at T1 predicted increases in oppositional defiant disorder symptoms at T2. Children with more sleep problems and higher PSIS Sleep Reinforcement scores at T1 showed increases in attention deficit/hyperactivity disorder, depressive, and anxiety symptoms at T2. These findings provide evidence for the predictive validity of the PSIS and highlight the importance of early parent–child sleep interactions in the development of sleep and psychiatric symptoms in childhood. Parent–child sleep interactions may serve as a useful target for interventions. 相似文献
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An evaluation of the challenges to developing tumor BRCA1 and BRCA2 testing methodologies for clinical practice 下载免费PDF全文
Miika Ahdesmäki Sally Luke Paul M. Waring Andrew Wallace Ronnie Wright Benno Röthlisberger Katja Ludin Sabine Merkelbach‐Bruse Carina Heydt Marjolijn J.L. Ligtenberg Arjen R. Mensenkamp David Gonzalez de Castro Thomas Jones Ana Vivancos Olga Kondrashova Patrick Pauwels Christine Weyn Eric Hahnen Jan Hauke Richie Soong Zhongwu Lai Brian Dougherty T. Hedley Carr Justin Johnson John Mills J. Carl Barrett 《Human mutation》2018,39(3):394-405
Ovarian cancer patients with germline or somatic pathogenic variants benefit from treatment with poly ADP ribose polymerase (PARP) inhibitors. Tumor BRCA1/2 testing is more challenging than germline testing as the majority of samples are formalin‐fixed paraffin embedded (FFPE), the tumor genome is complex, and the allelic fraction of somatic variants can be low. We collaborated with 10 laboratories testing BRCA1/2 in tumors to compare different approaches to identify clinically important variants within FFPE tumor DNA samples. This was not a proficiency study but an inter‐laboratory comparison to identify common issues. Each laboratory received the same tumor DNA samples ranging in genotype, quantity, quality, and variant allele frequency (VAF). Each laboratory performed their preferred next‐generation sequencing method to report on the variants. No false positive results were reported in this small study and the majority of methods detected the low VAF variants. A number of variants were not detected due to the bioinformatics analysis, variant classification, or insufficient DNA. The use of hybridization capture or short amplicon methods are recommended based on a bioinformatic assessment of the data. The study highlights the importance of establishing standards and standardization for tBRCA testing particularly when the test results dictate clinical decisions regarding life extending therapies. 相似文献
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Outcomes of early parent‐child adrenocortical attunement in the high‐risk offspring of depressed parents 下载免费PDF全文
Stephanie M. Merwin Chelsey Barrios Victoria C. Smith Edward P. Lemay Jr Lea R. Dougherty 《Developmental psychobiology》2018,60(4):468-482
This study examined the impact of parent‐child attunement of morning cortisol on parenting and child outcomes in dyads with and without parental depression. Participants included 142 parent‐child dyads (3–5 years‐old) who provided morning cortisol samples at Wave 1, and 98 dyads returned for the 3‐year follow‐up at Wave 2. Results indicated that for parents with a history of depression and for female children, stronger attunement predicted increases in parental hostility from Wave 1 to Wave 2. For females only, stronger attunement was related to children's depressive symptoms at Wave 1 and Wave 2. Stronger attunement was also associated with increases in children's depressive symptoms from Wave 1 to Wave 2, poorer psychosocial functioning at Wave 1, and ADHD symptoms at Wave 2. Findings highlight attunement as an important biological process related to parenting and child outcomes and suggest it may play a role in the intergenerational transmission of depression risk. 相似文献
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Association between early inhibition of DNA synthesis and the MICs and MBCs of carboxyquinolone antimicrobial agents for wild-type and mutant [gyrA nfxB(ompF) acrA] Escherichia coli K-12. 总被引:1,自引:13,他引:1 下载免费PDF全文
R T Chow T J Dougherty H S Fraimow E Y Bellin M H Miller 《Antimicrobial agents and chemotherapy》1988,32(8):1113-1118
Quinolone antimicrobial agents are known to interact with DNA gyrase, but the mechanism by which bacterial cell death occurs is not fully understood. In order to determine whether there is a correlation between quinolone-induced inhibition of early (i.e., 10 to 15 min) DNA synthesis and potency (MICs and MBCs), we measured the rate of DNA synthesis in log-phase Escherichia coli K-12 by using [3H]thymidine incorporation. Three quinolones (ciprofloxacin, norfloxacin, and difloxacin) were selected based on their decreasing activity against reference strain KL16. All three quinolones caused an early 50% inhibition of DNA synthesis which was proportional to MICs and MBCs (r greater than 0.99). Furthermore, 50% inhibition of DNA synthesis and MICs were nearly identical for mutant strains with an altered quinolone target (gyrA) or with decreased [nfxB(ompF)] or increased (acrA) permeability. There were significant differences (P less than 0.001) between individual quinolones in the degree of DNA synthesis inhibition in nalidixic acid-resistant gyrA and nfxB(ompF) mutant strains. The comparison of the three mutants with the wild-type strain permitted an in vivo examination of the effects of alterations of the drug target or entry on the activity determined by DNA synthesis inhibition and MICs. 相似文献
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Cata JP Cordella JV Burton AW Hassenbusch SJ Weng HR Dougherty PM 《Journal of pain and symptom management》2004,27(1):72-78
We present two patients with chemotherapy-induced painful neuropathy that had been poorly controlled with medications but successfully treated with spinal cord stimulation (SCS). A trial period of SCS provided effective pain relief in both patients who subsequently underwent permanent stimulator implantation. Psychophysical tests were performed before and after the implantation of trial and permanent stimulators. SCS improved pain scores and facilitated a reduction of medications. Both patients reported improved gait and one of them also reported an increase in leg flexibility. Psychophysical tests demonstrated an improvement in touch and sharpness detection thresholds. In summary, SCS offers a therapeutic option for patients with chemotherapy-induced peripheral neuropathy who have poor pain relief with standard medical treatment. 相似文献
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