首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   7938篇
  免费   603篇
  国内免费   66篇
耳鼻咽喉   68篇
儿科学   199篇
妇产科学   61篇
基础医学   954篇
口腔科学   185篇
临床医学   508篇
内科学   2265篇
皮肤病学   373篇
神经病学   431篇
特种医学   377篇
外科学   1405篇
综合类   21篇
一般理论   1篇
预防医学   171篇
眼科学   86篇
药学   445篇
中国医学   9篇
肿瘤学   1048篇
  2023年   119篇
  2022年   88篇
  2021年   321篇
  2020年   214篇
  2019年   287篇
  2018年   357篇
  2017年   331篇
  2016年   344篇
  2015年   330篇
  2014年   425篇
  2013年   438篇
  2012年   747篇
  2011年   756篇
  2010年   381篇
  2009年   308篇
  2008年   512篇
  2007年   572篇
  2006年   496篇
  2005年   459篇
  2004年   372篇
  2003年   289篇
  2002年   235篇
  2001年   27篇
  2000年   14篇
  1999年   23篇
  1998年   23篇
  1997年   24篇
  1996年   16篇
  1995年   14篇
  1994年   13篇
  1993年   12篇
  1992年   12篇
  1991年   11篇
  1990年   5篇
  1989年   6篇
  1988年   4篇
  1987年   3篇
  1986年   2篇
  1985年   3篇
  1984年   3篇
  1983年   2篇
  1981年   1篇
  1980年   1篇
  1979年   1篇
  1978年   1篇
  1977年   2篇
  1973年   3篇
排序方式: 共有8607条查询结果,搜索用时 15 毫秒
1.
Tsukamurella species are obligate aerobic, gram-positive, weak acid-fast, nonmotile bacilli. They are found in various environments, such as soil, water, sludge, and petroleum reservoir wastewater, and belong to the order Actinomycetales. In 2016, there was a reclassification of species within the genus Tsukamurella, merging the species Tsukamurella tyrosinosolvens (T. tyrosinosolvens) and Tsukamurella carboxydivorans. Tsukamurella species are clinically considered to be a rare opportunistic pathogen, because most reported cases have been related to bacteremia and intravascular prosthetic devices and immunosuppression. To date, it has been isolated only from human specimens, and has always been associated with clinical disease; human infections are very rare. Reported infections have included pneumonia, brain abscesses, catheter-related bloodstream infections, ocular infections, bacteremia, and sepsis presenting with septic pulmonary emboli in patients who are immunocompromised. To date, there is no commercially available test for identification. On the other hand, sequence-based identification, including matrix-assisted laser desorption ionization time-of-flight mass spectrometry, is an alternative method for identifying clinical isolates that are either slow growers or difficult to identify through biochemical profiling. The golden standards for diagnosis and optimal management still remain to be determined. However, newer molecular biological techniques can provide accurate identification, and contribute to the appropriate selection of definitive therapy for infections caused by this organism. Combinations of several antimicrobial agents have been proposed for treatment, though the length of treatment for infections has yet to be determined, and should be individualized according to clinical response. Immunocompromised patients often experience severe cases due to infection, and life-threatening T. tyrosinosolvens events associated with dissemination and/or failure of source control have occurred. Favorable prognoses can be achieved through earlier identification of the cause of infection, as well as successful management, including appropriate antibiotic therapy together with source control. Further analyses of similar cases are required to establish the most adequate diagnostic methods and treatment regimens for infections.  相似文献   
2.
International Journal of Clinical Oncology - This study aimed to investigate the clinical benefit of dose-dense paclitaxel plus carboplatin (TC) with bevacizumab therapy for advanced ovarian,...  相似文献   
3.
4.
International Journal of Clinical Oncology - Identifying lateral pelvic lymph node (LPN) metastasis in low rectal cancer is crucial before treatment. Several risk factors and prediction models for...  相似文献   
5.
6.
7.
8.
International Journal of Clinical Oncology - The practice of cancer diagnosis disclosure to children has been changed with the times. The regulations of clinical trials in the 2000s might change...  相似文献   
9.
10.
IntroductionAnti-methicillin-resistant Staphylococcus aureus (MRSA) agents have different doses and administration periods. Thus, it is difficult to evaluate antimicrobial use (AMU) of anti-MRSA agents using defined daily doses per 1000 inhabitants per day (DID) or days of therapy per 1000 inhabitants per day (DOTID). This study aimed to evaluate the relationship between anti-MRSA agent use and resistant bacteria using the number of patients per 1000 inhabitants per day (PID) as an alternative index of AMU.MethodsAMU data for anti-MRSA agents were collected from the National Database of Health Insurance Claims and Specific Health Checkups (NDB) in 2016. The relationship between PID and DID or DOTID was evaluated. The number of patients with MRSA isolated was obtained from Japan Nosocomial Infections Surveillance, and their correlation with PID was analyzed. The rate of anti-MRSA agent use in each prefecture was investigated.ResultsPID showed a significant linear relationship with both DID and DOTID (all p < 0.0001). PID was significantly correlated with the number of patients with MRSA isolated. Additionally, the rate of anti-MRSA agent use was markedly different in each region.ConclusionsPID is not affected by doses and administration periods, and thus may be an alternative index for the selective pressure of antibiotics. Evaluating AMU using PID based on NDB data will help in the development of effective antimicrobial resistance measures.  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号