全文获取类型
收费全文 | 6638篇 |
免费 | 463篇 |
国内免费 | 19篇 |
专业分类
耳鼻咽喉 | 70篇 |
儿科学 | 262篇 |
妇产科学 | 105篇 |
基础医学 | 765篇 |
口腔科学 | 159篇 |
临床医学 | 1347篇 |
内科学 | 1073篇 |
皮肤病学 | 53篇 |
神经病学 | 680篇 |
特种医学 | 69篇 |
外科学 | 526篇 |
综合类 | 97篇 |
一般理论 | 6篇 |
预防医学 | 901篇 |
眼科学 | 102篇 |
药学 | 431篇 |
1篇 | |
中国医学 | 4篇 |
肿瘤学 | 469篇 |
出版年
2023年 | 58篇 |
2022年 | 22篇 |
2021年 | 120篇 |
2020年 | 105篇 |
2019年 | 147篇 |
2018年 | 175篇 |
2017年 | 112篇 |
2016年 | 128篇 |
2015年 | 159篇 |
2014年 | 250篇 |
2013年 | 390篇 |
2012年 | 529篇 |
2011年 | 551篇 |
2010年 | 295篇 |
2009年 | 279篇 |
2008年 | 420篇 |
2007年 | 499篇 |
2006年 | 445篇 |
2005年 | 475篇 |
2004年 | 411篇 |
2003年 | 369篇 |
2002年 | 371篇 |
2001年 | 39篇 |
2000年 | 37篇 |
1999年 | 50篇 |
1998年 | 62篇 |
1997年 | 43篇 |
1996年 | 28篇 |
1995年 | 45篇 |
1994年 | 35篇 |
1993年 | 40篇 |
1992年 | 30篇 |
1991年 | 20篇 |
1990年 | 30篇 |
1989年 | 16篇 |
1988年 | 20篇 |
1987年 | 21篇 |
1986年 | 16篇 |
1985年 | 25篇 |
1984年 | 24篇 |
1983年 | 25篇 |
1982年 | 39篇 |
1981年 | 29篇 |
1980年 | 22篇 |
1979年 | 16篇 |
1978年 | 13篇 |
1977年 | 12篇 |
1976年 | 8篇 |
1975年 | 11篇 |
1974年 | 8篇 |
排序方式: 共有7120条查询结果,搜索用时 24 毫秒
1.
Cynthia S. E. Hendrikse MD Phyllis van der Ploeg MD PhD Nienke M. A. van de Kruis MD Jody H. C. Wilting MD Floor Oosterkamp BSc Pauline M. M. Theelen MSc Christianne A. R. Lok MD PhD Joanne A. de Hullu MD PhD Huberdina P. M. Smedts MD PhD M. Caroline Vos MD PhD Brenda M. Pijlman MD Loes F. S. Kooreman MD Johan Bulten MD PhD Marjolein H. F. M. Lentjes-Beer MD PhD Steven L. Bosch MD PhD Anja van de Stolpe MD PhD Sandrina Lambrechts MD PhD Ruud L. M. Bekkers MD PhD Jurgen M. J. Piek MD PhD 《Cancer》2023,129(9):1361-1371
Background
Advanced low-grade ovarian carcinoma (LGOC) is difficult to treat. In several studies, high estrogen receptor (ER) protein expression was observed in patients with LGOC, which suggests that antihormonal therapy (AHT) is a treatment option. However, only a subgroup of patients respond to AHT, and this response cannot be adequately predicted by currently used immunohistochemistry (IHC). A possible explanation is that IHC only takes the ligand, but not the activity, of the whole signal transduction pathway (STP) into account. Therefore, in this study, the authors assessed whether functional STP activity can be an alternative tool to predict response to AHT in LGOC.Methods
Tumor tissue samples were obtained from patients with primary or recurrent LGOC who subsequently received AHT. Histoscores of ER and progesterone receptor (PR) were determined. In addition, STP activity of the ER STP and of six other STPs known to play a role in ovarian cancer was assessed and compared with the STP activity of healthy postmenopausal fallopian tube epithelium.Results
Patients who had normal ER STP activity had a progression-free survival (PFS) of 16.1 months. This was significantly shorter in patients who had low and very high ER STP activity, with a median PFS of 6.0 and 2.1 months, respectively (p < .001). Unlike ER histoscores, PR histoscores were strongly correlated to the ER STP activity and thus to PFS.Conclusions
Aberrant low and very high functional ER STP activity and low PR histoscores in patients with LGOC indicate decreased response to AHT. ER IHC is not representative of functional ER STP activity and is not related to PFS. 相似文献2.
James I. Geller MD Joseph G. Pressey MD Malcolm A. Smith MD Rachel A. Kudgus PhD Mariana Cajaiba MD Joel M. Reid PhD David Hall PhD Donald A. Barkauskas PhD Stephen D. Voss MD Steve Y. Cho MD Stacey L. Berg MD Jeffrey S. Dome MD PhD Elizabeth Fox MD Brenda J. Weigel MD 《Cancer》2020,126(24):5303-5310
3.
Maciej M. Mrugala Bryan Kim Akanksha Sharma Natalie Johnson Carrie Graham Brenda F. Kurland Julie Gralow 《Clinical breast cancer》2019,19(5):311-316
Metastatic breast cancer frequently leads to brain metastases and, less commonly, leptomeningeal carcinomatosis (LC). Once cerebrospinal fluid involvement occurs, the prognosis is poor. There are limited treatment options available, but none offer significant survival benefit. Methotrexate, given systemically at high doses (3.5-8 gm/m2), achieves cytotoxic concentrations in the CSF and has been shown to prolong survival in patients with LC. Intrathecal liposomal cytarabine has been shown to increase time to neurologic progression in patients with breast cancer and LC. The combination of these 2 agents in LC has not been studied extensively. Here, we present the results of the phase II study with this combination showing promising efficacy and very good tolerability. 相似文献
4.
5.
6.
Yang Lin Wu Hui de Winter Brenda C. M. Sheng Chang-cheng Qiu Hong-qiang Cheng Yu Chen Juan Zhao Qiu-ling Huang Jing Jiao Zheng Xie Rui-xiang 《Cancer chemotherapy and pharmacology》2020,85(5):881-897
Cancer Chemotherapy and Pharmacology - High-dose methotrexate (HD-MTX) is widely used in the treatment of non-Hodgkin lymphoma (NHL), but the pharmacokinetic properties of HD-MTX in Chinese adult... 相似文献
7.
Brenda Laky Isabella Alram Julia K. Frank Leo Pauzenberger Werner Anderl Karl-Heinz Wagner Philipp R. Heuberer 《Journal of orthopaedic research》2020,38(9):2074-2082
Increasing numbers of arthroplasties are also accompanied by postoperative infections. The main purpose was to evaluate preoperative serum bilirubin levels between patients with and without infections after shoulder and knee arthroplasties. For this retrospective case-control single-center study, a total of 108 patients were extracted from a prospectively collected database. Eighteen patients with infections after shoulder (n = 8) and knee (n = 10) arthroplasty were matched by age, gender, and implant type in a 1:5-scenario to 90 patients (40 shoulders and 50 knees) without postoperative infection. Demographic data, preoperative blood parameters, and postoperative infection-related outcomes were evaluated. Total bilirubin was the only preoperative parameter significantly different between the infection (8.21 ± 3.25 μmol/L or 0.48 ± 0.19 mg/dL) and noninfection (10.78 ± 4.62 μmol/L or 0.63 ± 0.27 mg/dL; P = .014) group, while C-reactive protein and other liver parameters were similar between the groups. Significantly more controls (92.1%) had preoperative bilirubin levels above 8.72 μmol/L or 0.51 mg/dL than cases (7.9%; P = .007). The 5-year infection survival-rate was 65.6% for patients with preoperative bilirubin levels < 8.72 μmol/L or < 0.51 mg/dL and 91.2% with ≥ 8.72 μmol/L or ≥ 0.51 mg/dL. Mildly decreased preoperative bilirubin levels with a cutoff at 8.72 μmol/L or 0.51 mg/dL were significantly associated to patients with infections after shoulder and knee arthroplasty. There were no differences in other blood parameters or comorbidities between patients with infections and their matched-controls. 相似文献
8.
Meagan R. Conner Oluwadamilola M. Adeyemi Brenda J. Anderson Mary F. Kritzer 《The European journal of neuroscience》2020,52(1):2705-2723
Episodic memory involves the integration and recall of discrete events that include information about what happened, where it happened and when it occurred. Episodic memory function is critical to daily life, and its dysfunction is both a first identifiable indicator and an enduring core feature of cognitive decline in ageing and in neuropsychiatric disorders including Alzheimer's disease and schizophrenia. Available evidence from human studies suggests that biological sex and sex hormones modulate episodic memory function in health and disease. However, knowledge of how this occurs is constrained by the limited availability and underutilization of validated animal models in investigating hormone impacts on episodic‐like memory function. Here, adult female, adult male and gonadally manipulated adult male rats were tested on the what–where–when episodic‐like memory task to determine whether rats model human sex differences in episodic memory and how the hormonal milieu impacts episodic‐like memory processes in this species. These studies revealed salient ways in which rats model human sex differences in episodic memory, including a male advantage in spatial episodic memory performance. They also identified domain‐specific roles for oestrogens and androgens in modulating what, where and when discriminations in male rats that were unlike those engaged in corresponding novel object recognition and novel object location tasks. These studies thus identify rats and the what–where–when task as suitable for investigating the neuroendocrine bases of episodic‐like memory, and provide new information about the unique contributions that sex and sex hormones make to this complex mnemonic process. 相似文献
9.
Behzad Bidadi Andrea Watson Brenda Weigel Andre Oliveira Justin Kirkham Carola Arndt 《Pediatric blood & cancer》2020,67(6)
Infantile myofibromatosis (IM) is characterized by solitary musculoskeletal nodules presenting during infancy but can manifest as multiple lesions with visceral involvement. Multicentric IM with visceral involvement carries a high risk of mortality and there is no consensus on treatment. We present a case of a patient with multicentric IM and pulmonary involvement who progressed on several chemotherapeutic regimens and subsequently had a complete response to sorafenib and later imatinib. This report describes the novel use of sorafenib and imatinib to treat generalized IM and the role of continued tyrosine kinase inhibitor therapy to maintain remission. 相似文献