全文获取类型
收费全文 | 6863篇 |
免费 | 720篇 |
国内免费 | 15篇 |
专业分类
耳鼻咽喉 | 45篇 |
儿科学 | 268篇 |
妇产科学 | 174篇 |
基础医学 | 995篇 |
口腔科学 | 102篇 |
临床医学 | 801篇 |
内科学 | 1245篇 |
皮肤病学 | 87篇 |
神经病学 | 648篇 |
特种医学 | 197篇 |
外科学 | 842篇 |
综合类 | 133篇 |
一般理论 | 16篇 |
预防医学 | 909篇 |
眼科学 | 165篇 |
药学 | 506篇 |
中国医学 | 16篇 |
肿瘤学 | 449篇 |
出版年
2021年 | 102篇 |
2020年 | 72篇 |
2019年 | 107篇 |
2018年 | 144篇 |
2017年 | 104篇 |
2016年 | 128篇 |
2015年 | 121篇 |
2014年 | 176篇 |
2013年 | 260篇 |
2012年 | 385篇 |
2011年 | 387篇 |
2010年 | 217篇 |
2009年 | 230篇 |
2008年 | 376篇 |
2007年 | 379篇 |
2006年 | 332篇 |
2005年 | 353篇 |
2004年 | 320篇 |
2003年 | 326篇 |
2002年 | 253篇 |
2001年 | 181篇 |
2000年 | 169篇 |
1999年 | 131篇 |
1998年 | 65篇 |
1997年 | 60篇 |
1996年 | 56篇 |
1995年 | 68篇 |
1994年 | 57篇 |
1993年 | 75篇 |
1992年 | 145篇 |
1991年 | 131篇 |
1990年 | 150篇 |
1989年 | 95篇 |
1988年 | 104篇 |
1987年 | 122篇 |
1986年 | 91篇 |
1985年 | 116篇 |
1984年 | 82篇 |
1983年 | 66篇 |
1982年 | 38篇 |
1981年 | 41篇 |
1980年 | 35篇 |
1979年 | 60篇 |
1978年 | 40篇 |
1975年 | 55篇 |
1974年 | 56篇 |
1973年 | 47篇 |
1972年 | 36篇 |
1971年 | 40篇 |
1970年 | 41篇 |
排序方式: 共有7598条查询结果,搜索用时 15 毫秒
1.
Marc Evans MD Susanne Engberg MD Mads Faurby MSc João Diogo Da Rocha Fernandes MSc Pollyanna Hudson MSc William Polonsky PhD 《Diabetes, obesity & metabolism》2022,24(3):377-390
We designed a systematic literature review to identify available evidence on adherence to and persistence with antidiabetic medication in people with type 2 diabetes (T2D). Electronic screening and congress searches identified real-world noninterventional studies (published between 2010 and October 2020) reporting estimates of adherence to and persistence with antidiabetic medication in adults with T2D, and associations with glycaemic control, microvascular and/or macrovascular complications, hospitalizations and healthcare costs. Ninety-two relevant studies were identified, the majority of which were retrospective and reported US data. The proportions of patients considered adherent (median [range] 51.2% [9.4%-84.3%]) or persistent (median [range] 47.7% [16.9%-94.0%]) varied widely across studies. Multiple studies reported an association between greater adherence/persistence and greater reductions in glycated haemoglobin levels. Better adherence/persistence was associated with fewer microvascular and/or macrovascular outcomes, although there was little consistency across studies in terms of which outcomes were improved. More adherent and more persistent patients were typically less likely to be hospitalized or to have emergency department visits/admissions and spent fewer days in hospital annually than less adherent/persistent patients. Greater adherence and persistence were generally associated with lower hospitalization costs, higher pharmacy costs and lower or budget-neutral total healthcare costs compared with lower adherence/persistence. In conclusion, better adherence and persistence in people with T2D is associated with lower rates of microvascular and/or macrovascular outcomes and inpatient hospitalization, and lower or budget-neutral total healthcare expenditure. Education and treatment strategies to address suboptimal adherence and persistence are needed to improve clinical and economic outcomes. 相似文献
2.
Malinda Itchins Brandon Lau Amanda L. Hudson Helen Westman Cathy Yi Xia Sarah A. Hayes Viive M. Howell Michael Rodriguez Wendy A. Cooper Heng Wei Michael Buckland Bob T. Li Mark Li Vivek Rathi Stephen B. Fox Anthony J. Gill Stephen J. Clarke Michael J. Boyer Nick Pavlakis 《The oncologist》2020,25(8):641-649
3.
4.
5.
Perinatal hypoxic-ischemic encephalopathy is a leading cause of neonatal death and disability.Therapeutic hypothermia significantly reduces death and major disability associated with hypoxic-ischemic encephalopathy;however,many infants still experience lifelong disabilities to movement,sensation and cognition.Clinical guidelines,based on strong clinical and preclinical evidence,recommend therapeutic hypothermia should be started within 6 hours of birth and continued for a period of 72 hours,with a target brain temperature of 33.5 ±0.5℃ for infants with moderate to severe hypoxic-ischemic encephalopathy.The clinical guidelines also recommend that infants be re warmed at a rate of 0.5℃ per hour,but this is not based on strong evidence.There are no randomized controlled trials investigating the optimal rate of rewarming after therapeutic hypothermia for infants with hypoxic-ischemic encephalopathy.Preclinical studies of rewarming are conflicting and results were confounded by treatment with sub-optimal durations of hypothermia.In this review,we evaluate the evidence for the optimal start time,duration and depth of hypothermia,and whether the rate of rewarming after treatment affects brain injury and neurological outcomes. 相似文献
6.
The unifying theme for the papers in this volume is that event‐predictive representations play an important role in cognitive processes, and they are a particularly fruitful object of study for cognitive scientists. In this paper, we present our own model of event representations that draws together several disparate strands of research into event representations, relating to event perception, event encodings in working memory and their role in prediction, and events as they are reported in language. Our main claim is that the notion of deictic routines originally developed by Ballard et al. (1997) is of great use in explaining how these different types of event representation interface with one another. 相似文献
7.
Paulo Roberto Lima Falco do Vale Sheila Cerqueira Hudson P. Santos Beth P. Black Evanilda Souza de Santana Carvalho 《Nursing inquiry》2019,26(1)
The rapidly increasing number of cases of Zika virus and limited understanding of its congenital sequelae (e.g., microcephaly) led to stories of fear and uncertainty across social media and other mass communication networks. In this study, we used techniques generic to netnography, a form of ethnography, using Internet‐based computer‐mediated communications as a source of data to understand the experience and perceptions of families with infants diagnosed with Zika‐related microcephaly. We screened 27 YouTube? videos published online between October 2015 and July 2016, during which the Zika epidemic started, peaked, and declined. We identified three themes: (a) experiencing the news of a diagnosis of Zika‐associated microcephaly; (b) experiencing feelings and expectations of the ‘imperfect’ child; and (c) seeking to understand microcephaly to care for the child. We found that families experienced distressing feelings of shock, sadness, hopelessness, and pain, while dealing with emerging and sometimes conflicting information being transmitted by news outlets, uncertainty about the child's health, and healthcare providers’ lack of clarity to guide the family members. The ‘unknown’ factor of ZIKA was an additional stressful factor in the experience of the families. 相似文献
8.
Verbruggen Lisanne C. Hudson Melissa M. Bowers Daniel C. Ronckers Cécile M. Armstrong Gregory T. Skinner Roderick Hoving Eelco W. Janssens Geert O. van der Pal Helena J. H. Kremer Leontine C. M. Mulder Renée L. 《Journal of neuro-oncology》2020,147(2):417-425
Journal of Neuro-Oncology - Childhood, adolescent and young adult (CAYA) cancer survivors treated with cranial radiotherapy are at risk for developing subsequent meningiomas. There is insufficient... 相似文献
9.
10.
Bob Gray Lisa Tuckley Charlotte Cutler Simon Biddle Simon Hudson Simon Gower Lynn Vanhaecke 《Drug testing and analysis》2020,12(6):731-742
Animal sport doping control laboratories are constantly reviewing ways in which they can improve their service offering whilst ensuring that they remain economically viable. This paper describes the development and assessment of a rapid and economical method for the detection of intact glucuronide conjugates of three anabolic steroids and their metabolites along with three corticosteroids in canine urine. The analysis of intact drug conjugates for animal sport doping control is generally not performed routinely as it presents a number of analytical challenges, not least of which is the lack of availability of appropriate reference standards. Here, we report the development of a UHPLC–MS/MS method using APCI in the negative ion mode for the detection of intact phase II conjugates, including the importance of in vitro incubations in order to provide appropriate reference materials. Cross‐validation of the developed method demonstrated that the detection capability of the intact phase II conjugates of stanozolol, boldenone, nandrolone, and their metabolites along with the corticosteroids dexamethasone and methylprednisolone was equivalent to that achieved in routine race‐day screens. The new process has been in operation for approximately 2 years and has been used to analyze in excess of 13500 canine urine samples, resulting in a number of positive screening findings. To the best of our knowledge, this is the first reported use of a routine screen for intact drug conjugates within animal sport doping control. 相似文献