首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   43458篇
  免费   3139篇
  国内免费   152篇
耳鼻咽喉   421篇
儿科学   1631篇
妇产科学   1044篇
基础医学   5024篇
口腔科学   857篇
临床医学   4581篇
内科学   8771篇
皮肤病学   753篇
神经病学   4214篇
特种医学   1447篇
外科学   6774篇
综合类   834篇
一般理论   60篇
预防医学   3577篇
眼科学   1149篇
药学   3071篇
中国医学   43篇
肿瘤学   2498篇
  2023年   143篇
  2021年   510篇
  2020年   421篇
  2019年   714篇
  2018年   837篇
  2017年   664篇
  2016年   662篇
  2015年   854篇
  2014年   1215篇
  2013年   1848篇
  2012年   2821篇
  2011年   3034篇
  2010年   1719篇
  2009年   1577篇
  2008年   2808篇
  2007年   3005篇
  2006年   2971篇
  2005年   3032篇
  2004年   2869篇
  2003年   2640篇
  2002年   2642篇
  2001年   524篇
  2000年   392篇
  1999年   490篇
  1998年   587篇
  1997年   427篇
  1996年   384篇
  1995年   379篇
  1994年   344篇
  1993年   338篇
  1992年   342篇
  1991年   295篇
  1990年   275篇
  1989年   279篇
  1988年   255篇
  1987年   217篇
  1986年   260篇
  1985年   260篇
  1984年   339篇
  1983年   277篇
  1982年   342篇
  1981年   303篇
  1980年   297篇
  1979年   184篇
  1978年   178篇
  1977年   176篇
  1976年   149篇
  1975年   140篇
  1974年   158篇
  1973年   124篇
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Journal of Clinical Immunology - Immune responses to coronavirus disease 2019 (COVID-19) mRNA vaccines in primary antibody deficiencies (PADs) are largely unknown. We investigated antibody and CD4+...  相似文献   
2.
3.
Quality of Life Research - To develop two item content-matched, precise, score-level targeted inpatient physical function (PF) short form (SF) measures: one clinician-reported, one...  相似文献   
4.
5.
G protein-coupled estrogen receptor-1 (GPER), a member of the G protein-coupled receptor (GPCR) superfamily, mediates estrogen-induced proliferation of normal and malignant breast epithelial cells. However, its role in breast cancer stem cells (BCSCs) remains unclear. Here we showed greater expression of GPER in BCSCs than non-BCSCs of three patient-derived xenografts of ER/PR+ breast cancers. GPER silencing reduced stemness features of BCSCs as reflected by reduced mammosphere forming capacity in vitro, and tumor growth in vivo with decreased BCSC populations. Comparative phosphoproteomics revealed greater GPER-mediated PKA/BAD signaling in BCSCs. Activation of GPER by its ligands, including tamoxifen (TMX), induced phosphorylation of PKA and BAD-Ser118 to sustain BCSC characteristics. Transfection with a dominant-negative mutant BAD (Ser118Ala) led to reduced cell survival. Taken together, GPER and its downstream signaling play a key role in maintaining the stemness of BCSCs, suggesting that GPER is a potential therapeutic target for eradicating BCSCs.  相似文献   
6.
7.
8.
In this article, we examine the social management of fatness via an analysis of 4 years of participant‐observation in military‐style fitness boot camps and interviews with camp participants, trainers and organisers/owners. We begin by focusing on popular imagery of the ‘boot camp’. The boot camp model takes various forms; yet, whether it involves civilian participants, as on reality television shows, or the imagined military ones of films, the boot camp model emphasises the re‐fashioning of the individual via the disciplining of bodies and selves. Such constructions of boot camps were employed by our respondents to lay claim to identities which highlight their hard work, strength of character, fundamental ‘goodness’ and self‐discipline, as those qualities are demonstrated through the body – even though participants’ actual bodies change little at camp. Such meanings stand in direct contradiction to broader social constructions of fatness and participants’ own negative perceptions of fat people. Moreover, even within the camps themselves, such identity claims are contested, both by camp trainers and by slimmer and ‘fitter’ attendees. These counterclaims are grounded in ideas about the characterological implications of the fat body, beliefs about the purpose of boot camp and notions of the body's capacity for change.  相似文献   
9.
Hypoalbuminemia is associated with inflammation. Despite being addressed repeatedly in the literature, there is still confusion regarding its pathogenesis and clinical significance. Inflammation increases capillary permeability and escape of serum albumin, leading to expansion of interstitial space and increasing the distribution volume of albumin. The half‐life of albumin has been shown to shorten, decreasing total albumin mass. These 2 factors lead to hypoalbuminemia despite increased fractional synthesis rates in plasma. Hypoalbuminemia, therefore, results from and reflects the inflammatory state, which interferes with adequate responses to events like surgery or chemotherapy, and is associated with poor quality of life and reduced longevity. Increasing or decreasing serum albumin levels are adequate indicators, respectively, of improvement or deterioration of the clinical state. In the interstitium, albumin acts as the main extracellular scavenger, antioxidative agent, and as supplier of amino acids for cell and matrix synthesis. Albumin infusion has not been shown to diminish fluid requirements, infection rates, and mortality in the intensive care unit, which may imply that there is no body deficit or that the quality of albumin “from the shelf” is unsuitable to play scavenging and antioxidative roles. Management of hypoalbuminaemia should be based on correcting the causes of ongoing inflammation rather than infusion of albumin. After the age of 30 years, muscle mass and function slowly decrease, but this loss is accelerated by comorbidity and associated with decreasing serum albumin levels. Nutrition support cannot fully prevent, but slows down, this chain of events, especially when combined with physical exercise.  相似文献   
10.
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号