全文获取类型
收费全文 | 396篇 |
免费 | 14篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 26篇 |
妇产科学 | 4篇 |
基础医学 | 27篇 |
口腔科学 | 6篇 |
临床医学 | 25篇 |
内科学 | 128篇 |
皮肤病学 | 9篇 |
神经病学 | 28篇 |
外科学 | 69篇 |
综合类 | 3篇 |
预防医学 | 15篇 |
眼科学 | 8篇 |
药学 | 40篇 |
中国医学 | 1篇 |
肿瘤学 | 20篇 |
出版年
2021年 | 9篇 |
2019年 | 4篇 |
2018年 | 6篇 |
2016年 | 8篇 |
2015年 | 14篇 |
2014年 | 17篇 |
2013年 | 12篇 |
2012年 | 11篇 |
2011年 | 6篇 |
2010年 | 9篇 |
2009年 | 11篇 |
2008年 | 6篇 |
2007年 | 14篇 |
2006年 | 19篇 |
2005年 | 13篇 |
2004年 | 9篇 |
2003年 | 13篇 |
2002年 | 5篇 |
2001年 | 6篇 |
2000年 | 4篇 |
1999年 | 7篇 |
1998年 | 15篇 |
1997年 | 20篇 |
1996年 | 12篇 |
1995年 | 13篇 |
1994年 | 16篇 |
1993年 | 13篇 |
1992年 | 11篇 |
1991年 | 5篇 |
1990年 | 5篇 |
1989年 | 6篇 |
1988年 | 4篇 |
1987年 | 5篇 |
1986年 | 4篇 |
1985年 | 4篇 |
1984年 | 3篇 |
1983年 | 2篇 |
1982年 | 2篇 |
1980年 | 2篇 |
1979年 | 4篇 |
1978年 | 5篇 |
1972年 | 1篇 |
1971年 | 2篇 |
1969年 | 1篇 |
1958年 | 18篇 |
1957年 | 8篇 |
1956年 | 10篇 |
1955年 | 4篇 |
1954年 | 5篇 |
1948年 | 1篇 |
排序方式: 共有410条查询结果,搜索用时 15 毫秒
1.
2.
3.
Hiroyasu KOIZUMI Eiichi SUEHIRO Yuichi FUJIYAMA Kazutaka SUGIMOTO Takao INOUE Michiyasu SUZUKI 《Neurologia medico-chirurgica》2014,54(11):870-877
Intracranial pressure (ICP) measurements are fundamental in the present protocols for intensive care of patients during the acute stage of severe traumatic brain injury. However, the latest report of a large scale randomized clinical trial indicated no association of ICP monitoring with any significant improvement in neurological outcome in severely head injured patients. Aggressive treatment of patients with therapeutic hypothermia during the acute stage of traumatic brain injury also failed to show any significant beneficial effects on clinical outcome. This lack of significant results in clinical trials has limited the therapeutic strategies available for treatment of severe traumatic brain injury. However, combined application of different types of neuromonitoring, including ICP measurement, may have potential benefits for understanding the pathophysiology of damaged brains. The combination of monitoring techniques is expected to increase the precision of the data and aid in prevention of secondary brain damage, as well as assist in determining appropriate time periods for therapeutic interventions. In this study, we have characterized the techniques used to monitor patients during the acute severe traumatic brain injury stage, in order to establish the beneficial effects on outcome observed in clinical studies conducted in the past and to follow up any valuable clues that point to additional strategies for aggressive management of these patients. 相似文献
4.
Kuniyasu NIIZUMA Hiroaki SHIMIZU Takashi INOUE Mika WATANABE Teiji TOMINAGA 《Neurologia medico-chirurgica》2014,54(10):812-818
Carotid endarterectomy (CEA) is intended to remove atheromatous plaque by dissecting a plane between the intima and the media (circular medial fibers), but this may not be the optimal dissection plane. The present technique is based on identifying the plane that divides the media from the plaque, so preserving the media on the adventitia as much as possible. This plane is more difficult to find and follow than the easy-to-dissect plane usually located between the media and the adventitia, because the plaque invades the media and so the dividing plane is located within the media. In this prospective observational study, CEA was performed in 22 patients to histologically examine the excised plaques and small samples of the whole arterial wall, and evaluate the clinical outcomes. Plaque had invaded the luminal part of the media in the whole arterial wall sample of 80% of cases. Thin medial layers covering > 80% of the surface of the plaque were found in 16 of 22 plaques (73%). Some atheromatous component was sometimes left in the preserved media, rather than completely removed with the media. No morbidity or mortality had occurred by discharge. Only 1 small ipsilateral infarction (4.5%) and no restenosis of greater than 50% were detected during the mean follow-up period of 7 years. Since the plaque usually invades the media, the optimum dissection plane may be located within the media, dividing it into two layers. The presence of some remnant atheromatous components in the preserved media was not associated with surgical complications or restenosis. 相似文献
5.
6.
7.
Time‐Dependent Changes in QT Dynamics after Initiation and Termination of Paroxysmal Atrial Fibrillation 下载免费PDF全文
8.
Katsuaki KANBE Kazuhiko INOUE Junji CHIBA Masahiko NOGUCHI Yoriko HIGUCHI Minako MURATA 《International journal of rheumatic diseases》2005,8(2):114-118
Aims: To investigate the efficacy and safety of leflunomide, including the side‐effects, we assessed 84 rheumatoid arthritis (RA) patients who received leflunomide treatment. Methods: We analyzed the C‐reactive protein (CRP), white blood cell count (WBC), KL‐6, and visual analogue scale (VAS) scores, modified Stanford Health Assessment Questionnaire (MHAQ) score, American Rheumatism Association score (ACR20 and ACR50) within a time course after treatment with leflunomide. We treated 84 RA patients, 12 male and 72 female from 28 to 81‐years‐old, with an average age of 63.5 years. The patients were divided into three groups: a group consisting of 38 patients who received 100 mg/day of leflunomide for 3 days followed by 20 mg/day thereafter; a second group of 11 patients who received a no‐loading dose of 10 mg/day; and a third group of 35 patients who received a no loading dose of 20 mg/day. Results: The 50% decrease of CRP seen in 2 weeks was 52% of the total of 84 patients. The WBC score did not change significantly after the medication was given. The KL‐6 score did not change significantly, either. The VAS pain score improved 4 weeks later, and then further improved 8 weeks later. Therefore, RA patients using leflunomide obtained pain relief 4 weeks after commencing medication. The MHAQ score did not change significantly until 8 weeks after the patients started the medication. ACR20 was 62% and ACR50 was 38% at 8 weeks after treatment. The side‐effects of leflunomide observed in our patients were rash, respiratory infection, diarrhea, nausea, alopecia, muscle pain, headache, dizziness and general fatigue. Twenty‐three out of 84 patients experienced side‐effects (27%), and 48/84 (57%) experienced withdrawal. In our hospital, there were no patients who developed severe interstitial pneumonia (IP) or who died after taking leflunomide; however, the incidence of side‐effects of the 100 mg/day loading dose (42.1%) was 2.5 times higher than in the patients who received 20 mg/day (17.1%) of a no‐loading dose. Conclusion: Because of this, it is possible that a 100 mg/day loading dose is a relatively high risk dose in terms of causing side‐effects, especially for severely ill RA patients with a high CRP level. 相似文献
9.
SATORU SUZUKI M.D. Ph.D. NORIO ISHIKAWA Ph.D. YOSHITO INOUE M.D. Ph.D. YASUNORI CHO M.D. Ph.D. SHINYA INOUE M.D. KENICHI HASHIZUME M.D. Ph.D. YUJI AOKI 《Pacing and clinical electrophysiology : PACE》2010,33(9):1063-1073
Background: We have studied the acute and long‐term efficacy of overlapping biphasic impulse (OLBI) stimulation for atrial pacing with VDD pacemakers and demonstrated the feasibility of DDD pacing in OLBI with diagonally arranged half‐ring (Half‐Ring) electrodes. We made two three‐dimensional computational analysis models to verify our clinical studies. Methods and Results: Model I was composed of a heart, a pacemaker, and a human body. Model II was a cube with dimensions of 20 by 20 by 20 mm quarried from Model I for the detailed study of current density distributions. Laplace's equation was solved using the finite element method and the current density J was calculated. For Model I, the distal and proximal voltages were ?10 V, 0 V in bipolar and ?5 V, +5 V in OLBI, using Ring electrodes. In Model II, the actual measurements of electrode impedances obtained from the clinical study (1,180 Ω for Ring and 630 Ω for Half‐Ring) were added to the analysis conditions. Model I showed that OLBI produced more concentrated current density distributions than those by bipolar. According to Model II, at the atrial myocardium position current density produced by Half‐Ring was larger than that by Ring electrodes, 70 μA/mm2 versus 30 μA/mm2 in OLBI configuration. It also indicated that even if electrode impedances were equal between Half‐Ring and Ring electrodes, the maximum current density produced by Half‐Ring would be greater than that by Ring electrodes. Conclusions: It was considered that OLBI configuration with Half‐Ring electrodes provides more effective current density distributions. (PACE 2010; 33:1063–1073) 相似文献
10.
Akiomi Inoue Norito Kawakami Masao Ishizaki Akihito Shimazu Masao Tsuchiya Masaji Tabata Miki Akiyama Akiko Kitazume Mitsuyo Kuroda 《International archives of occupational and environmental health》2010,83(1):29-38