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1.
肾细胞癌(renal cell carcinoma, RCC)是一种常见的泌尿系恶性肿瘤,随着早期肾细胞癌诊断率的不断提升,保留肾单位手术(nephron-sparing surgery, NSS)成为治疗T1期和部分T2期肾细胞癌的金标准,以肾部分切除术(partial nephrectomy, PN)应用广泛,但是该手术方式以及术后并发症存在一定的风险,因此术后评估肾功能对于评价手术安全性以及预测患者预后至关重要。本文介绍了近年来PN术后肾功能评估方法的研究进展。 相似文献
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甲氧基聚乙二醇体外修饰移植物细胞对单倍体相合小鼠造血干细胞移植后GVHD的影响 总被引:1,自引:0,他引:1
本研究探讨甲氧基聚乙二醇(mPEG)化学修饰移植物细胞对小鼠单倍体相合干细胞移植后移植物抗宿主病(GVHD)的影响.取经mPEG修饰及未修饰的成年CB6小鼠脾细胞悬液注入BALB/c新生幼鼠的腹腔(5×106脾细胞/只),以脾增大指标判断新生BALB/c小鼠注射单倍体相合供鼠脾细胞后的GVHD反应;取经mPEG修饰及未修饰的成年BALB/c小鼠骨髓及脾细胞混合悬液(BMS)尾静脉注入接受致死量γ射线照射后的成年BALB/c小鼠(2×105个BMS/只),注射后第8天取受鼠脾脏,计数脾结节数.结果表明修饰组脾指数1(SI1)较未修饰组减低,修饰组脾指数2(SI2)值<1.3,未修饰组SI2值>1.3,提示接受mPEG修饰的单倍体相合脾细胞输注后,修饰组GVHD程度较未修饰组轻;未修饰组与修饰组相比较,脾结节形成的数量差异无显著性意义(p>0.05),说明mPEG修饰不影响造血干祖细胞的活性.结论mPEG修饰移植物可减轻小鼠单倍体相合干细胞移植后的GVHD,而不影响干祖细胞活性. 相似文献
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<正>临床资料患者,男,27岁。因右下肢屈侧棕褐色丘疹4年,来我院就诊。患者4年前于右下肢屈侧发现一黄豆大棕褐色丘疹,边缘微红,表面光滑,界清,质硬,自诉捏之稍有痛感,否认其他自觉症状,无出血、破溃等现象,否认发病前局部外伤史及蚊虫叮咬史,未予治疗。其后患者自觉皮损渐增大,色加深,为求明确诊断,遂至我院就诊。患者自发病以来,饮 相似文献
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Background:AccordingtoAmericanHeartAssociation'sre-port,deathcompositionofcerebrovascularandcerebrovasculardis-easewasincreasedto29%in1996,andnow33%from25%in1992.Now,atherosclerosisseriouslyendangerhuman'shealth.Hypertension,hyperlipemiaandhyperviscositysyndromearemainriskfactorsofcardiovascularandcerebrovasculardis-eases.Thereconditionsoftenexistedsimultaneouslyinel-ders.Interventiontothesediseasescanpreventcardiovascularandcerebrovascularevents,whichisfeasi… 相似文献
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Background:According to American Heart Association's report,death composition of cerebrovascular and cerebrovascular disease was increased to 29% in 1996,and now 33% from 25% in 1992.Now,atherosclerosis seriously endanger human's health.Hypertension,hyperlipemia and hyperviscosity syndrome are main risk factors of cardiovascular and cerebrovascular diseases.There conditions often existed simultaneously in elders.Intervention to these diseases can prevent cardiovascular and cerebrovascular events,which is feasible. Objective:To investigate impact of hypertension,hyperlipemia and hyperviscosity syndrome on incidence of cardiovascular and cereborvascular events. Design:Random,controlled study. Unit:Department of Senile Diseases, Qianfoshan Hospital of Shandong. Subjects:In study group, 52 senile subjects with complete hospitalizing data were recruited from 1995~ 2000.Patients with hypertension,hyperlipemia ,hyperviscosity syndrome were included in the current study.13 subjects asked medical help due to hypertension,25 due to hyperlipemia and 14 due to hyperviscosity syndrome.Sometimes blood pressure of hypertension patients was 140~ 160/90~ 100 mmHg.Patients' mean age was 65.21.Ratio of male to female was 13:1.In control group,50 outpatients were included who had similar diseases those in study group.Mean age was 62.34 and ratio of male to female was 17.33:1. Intervention:In study group,calcium antagonist such as adalatcc, nitrendipine, plendil and/or ASCE inhibitor such as perindopril and captopril were given o.s.Blood pressure was con trolled to normal level.Blood lipid regulating drugs such as pravastatin, ticlopidine,and lipanthy were given for hyperlipemia patients.For patients with hyperviscosity syndrome,enteral aspirin or persantine was given,50~ 75 mg/day.Interval of drugs was 1 day to 2 months.Detailed data was unavailable.Red sage root or its compound form injecto was given i.v.,70 mg/day,pueraria root was given i.v.300~ 500 mg/day;astraglaus root was given 20~ 214 g/day,ginkgo leaf,70 mg/day.10~ 15 days was a disease course.Drugs were given for once in 17 subjects and twice 35 subjects.No subjects received 3 times of therapy.In control group,patients received no described treatment during 5 years.Outpatients' medical records as well as discharge record for inpatients were read to study conditions during five 5 years retrospectively. Main prognosis indexes:Collection point for statistical analysis was determined as begging phase of obervation and end point after 5 years.Cardiovascular events such as heart infarction,cerebrovascular disease such as cerebral infarction,cerebral hemorrhage and TIA were evaluated. Result: Incidence of cardiovascular and cerebrovascular events was markedly lower in study group compared with that in control group.In study group,2 subjects developed acute heart infarction(3.84% ),11 subejcts developed heart infarction in control group(22.00% )(P< 0.01).Ischemic cerebrovascular disease occurred in 1 subject(1.92% ) in study group and 7 in control group(14.00% ).Amount of cerebral hemorrhage showed no significant decrease in 1 subject (1.92% )in study group and 3 subjects in control group(6.00% )(P >0.05). Conclusion:Risk factors of cardiovascular and cerebrovascular disease in elders should be actively intervened to reduce development of cardiovascular and cerebrovascular disease. 相似文献
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功能性消化不良患者心理状态的调查分析 总被引:10,自引:0,他引:10
功能性消化不良(functional dyspepsia,FD)是指具有上腹痛、上腹胀、早饱、嗳气、食欲不振、恶心、呕吐等上腹不适症状,经检查排除引起这些症状的器质性疾病的一组临床综合征,症状可持续或反复发作,病程一般规定为超过1个月[1],是消化科的常见病.国外文献报道FD患病率为20%~40%[2]. 目前FD的发病机制尚未明确,但精神紧张和心理异常是重要成因为许多学者所共识[3].这部分患者在消化科门诊中占相当比例,尤其合并心理异常者认为症状严重和难以治疗而频繁就诊,这不仅影响患者生活质量,而且构成了相当高的医疗费用.我们对91例以消化道症状或失眠为主诉而被诊断为FD的患者进行心理测验,探讨FD患者焦虑、抑郁等不良心理状态,为临床治疗及有针对性的护理干预提供理论依据,从而提高患者的生活质量. 相似文献