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排序方式: 共有116条查询结果,搜索用时 62 毫秒
1.
黄芩甙,地塞米松对大鼠感染性脑水肿细胞因子的影响   总被引:20,自引:0,他引:20  
目的:探讨黄芩甙、地塞米松对大鼠感染性脑水肿白细胞介素-1(IL-1β)、肿瘤坏死因子α(TNF-α)的影响。方法:应用大鼠感染性脑水肿模型,采用干湿法、原子吸收分光光度法、ELISA测定各组脑组织水含量、钠离子含量及脑匀浆上清液中IL-β,TNF-α水平的变化;在光镜下观察各组脑组织的细胞形态学改变。结果:在大鼠感染性脑水肿(感脑)组脑水含量、钠离子、IL-1β、TNF-α含量均比生理盐水(对照  相似文献
2.
我国太行山高发区食管癌流行趋势及防治策略   总被引:18,自引:0,他引:18  
目的:对我国太行山区食管癌发病率及死亡率进行趋势分析及预测,并探索加速降低食管发病率和死亡率的策略,方法:采用磁到,林县1988-1997年食管部发病,死亡资料,并运用有反馈的人工神经网络模型预测其发病率,死亡率趋势;以林县临淇镇为例,测算以内间技术为主的早诊早治对于食管癌发病,死亡的降低程度及其把握度。结果:近10年来太行山区食管癌的发病率和死亡率均呈下降趋势,但较为缓慢,预测2002年食管癌发病率男性为115.70/10万,女性为79.88/10万,食管癌死亡率男性为94.00/10万,女性为56.29/10万,食管部发病率,死亡率均仍 较高水平,如推行以内窥镜为主的早诊早治技术8年中,干预组的发病率对照组的1/3,把握度可达到88.3%,死亡率在第5年时为对照组的1/4,把握度可达到89.4%,结论:太行山区食管癌发病率,死亡率均仍属较高水平,提示应该继续深入地在该地区开展食管癌的综合防治工作,推行以内窥镜技术为主的早期诊断,早期治疗,从而可在5-8年内明显地降低食管癌死亡率和发生率,建议在该地区进行较大规模的食管癌二级预防。  相似文献
3.
夜交藤煎剂的镇静催眠作用   总被引:11,自引:0,他引:11  
The sedative-hypnotic effect of Caulis Polygoni multiflori decoction (CPMD) was studied by the rolling cylinder method in mice and by the somnopolygraphic recording method in rats. The result from the rolling method in mice showed that CPMD (9g/kg) did have synergic action with the subthreshold hypnotic dose of sodium pentobarbital (20mg/kg). The result from the somnopolygraphic recording experiment showed that the immediate hypnotic effect of an effective dose of CPMD (20g/kg) was basically similar to that of diazepam (5mg/kg) used under the same experimental condition, chiefly an increase in the duration of slow wave sleep phase (SWS) and a decrease in the duration of paradoxical sleep phase (PS). By the end of a three-day session in dose of twice a day the hypnotic effect appeared more prominent and the reduction of SWS latency became significant.  相似文献
4.
保元汤对慢性乙型肝炎患者免疫调节的作用   总被引:11,自引:0,他引:11  
对60例慢性乙型肝炎患者外周血TL-CFU,mIL-2R,T细胞亚群免疫指标进行测定。结果表明:患者外周血TL-CFU值,mIL-2R,CD3^+,CD4^+和CD4^+/CD8^+值下降。CD8^+值均增高。经保元汤治疗后,上述各项指标(CD8^+降低外)均明显提高。提示慢性乙型肝炎患者存在免疫调节紊乱;保元汤有提高其免疫功能的作用。  相似文献
5.
内皮素及细胞因子在冠心病发病中的意义   总被引:9,自引:0,他引:9  
检测35例冠心病患者及20例健康才血浆内皮素(ET)、血清肿瘤坏死因子(TNF)及白细胞介素-6(IL-6)的水平。结果显示:与正常组比较,冠心病组ET及TNF水平均增高,尤以心肌梗死明显;冠状动脉狭窄组与对照组比较,IL-6水平无明显变化,但心肌梗死组IL-6水平则明显增高,提示血浆ET浓度及细胞因子的作用与冠心病的发生发展有关,而IL-6水平与急性心梗的免疫损伤有关。  相似文献
6.
72例多发性骨髓瘤单克隆蛋白分析   总被引:5,自引:0,他引:5  
Serum and urinary monoclonal proteins (M protein) were measured in 72 cases of multiple myeloma (MM) using rate nephelometry. In IgG and IgA types of MM, the level of immunoglobulin (Ig) corresponding to the malignant isotype was significantly higher and that of Ig uncorresponding to the malignant isotype lower than the normal level. The light chain corresponding to the malignant isotype in serum was increased and the light chain uncorresponding to that in serum was decreased either kappa-IgG, IgA types or lambda-IgG, IgA types. Either kappa-LC or lambda-LC type of MM, the serum light chain corresponding to the malignant isotype was in the normal range and uncorresponding to that was decreased, and the corresponding light chain in urine was significantly elevated. Kappa/lambda ratio in serum and urine was all significantly abnormal in IgG, IgA, and LC types of MM. Our data suggest that any quota among kappa light chain > 20 g.L-1 or < 5 g.L-1, lambda light chain > 10 g.L-1 or < 2 g.L-1 in serum and kappa/lambda ratio > 5 or < 0.75 in serum and urine has an important value for diagnosing MM.  相似文献
7.
中人氟安胸腔植入治疗晚期肺癌合并胸水36例   总被引:5,自引:0,他引:5  
李文献  杨军  陈静  杨友谊 《医学争鸣》2005,26(18):1663-1663
0引言2003-01/2004-07河南省南阳医学高等专科学校附属医院胸外科共收治晚期肺癌合并恶性胸水患者75例,对其中的36例采用一定剂量的中人氟安植入胸腔内进行灌注化疗,与同期对照组比较,无论在近期疗效或毒副作用等方面都有显著的临床效果.  相似文献
8.
Intestinal parasites in metropolitan Toronto day-care centres.   总被引:4,自引:0,他引:4       下载免费PDF全文
In 1981, 900 children (aged 3 months to 10 years) and 146 staff attending 22 day-care centres in metropolitan Toronto chosen at random provided a stool specimen in a survey for intestinal parasites. Of the children, 4% to 36% were infected in 20 of 22 centres. Overall, 19% of the children and 14% of the staff had intestinal parasites: 8.6% and 4.0% respectively had Dientamoeba fragilis, and 7.8% and 2.0% respectively had Giardia lamblia. The highest prevalence of dientamebiasis was in the 7- to 10-year-olds, whereas giardiasis was detected most frequently in the 6-year-olds. Infection with intestinal parasites was not correlated with age, sex, duration in the day-care centre, dog ownership, travel history, gastrointestinal symptoms or the proportion of children in the day-care centre who were born in less developed countries. Immigrant children and children of parents born in industrialized countries (including Canada) were more likely to be infected than were children born in Canada of parents from the developing world. Dientamebiasis was associated with cat ownership. Thus, intestinal protozoa--in particular, D. fragilis and G. lamblia--are endemic in Toronto day-care centres.  相似文献
9.
To quantitatively assess risk for lung cancer of metal miners,a historical cohort study was conducted.The cohort consisted of 1113 miners who were employed to underground work for at least 12 months between January 1,1960and December,12,1974,According to the records or dust concentration,a cumulative dust dose of each miner in the cohort was estimated.There wer 162 deaths in total and 45 deaths from lung cancer with a SMR of 2184,The SMR for lung cancer increased from 1019 for those with cumulative dust of less than 500mg-year to 2469 for those with the dose of greater than 4500mg-year.Furthermore,the risk in the highest category of combined cumulative dust dose and cigarette smoking was 46-fold greater than the lowest category of dust dose and smoking.This study showed that there was an exposure-response relationship between metal ore dust and lung cancer,and an interaction of lung cancer between smoking and metal ore dust exposure.  相似文献
10.
目的:比较黄芩甙与甘露醇、地塞米松对感染性脑水肿的治疗作用。为脑水肿的临床治疗探讨新的方法。方法:应用感染性脑水肿模型,将40只SD大鼠随机分为感染性脑水肿(BE)组、甘露醇治疗(MAN)组、地塞米松治疗(DXM)组、黄苷治疗(BC)组及生理盐水对照组(NS)组,观察脑组织含水量、干脑组织钠、钾离子含量、伊文思兰(EB)含量、脑组织病理形态学变化。结果:大鼠脑组织含水量、EB含量、钠离子含量BE组  相似文献
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