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OBJECTIVE: To evaluate the effect of gynostemma pentaphyllum mak (GP) on carcinomatous conversions of leukoplasia of the golden hamster cheek pouch induced by dimethylbenzanthracene (DMBA). METHODS: 284 golden hamsters, ranging from 4 to 8 weeks of age, 80 to 100 grams in weight were randomly divided into three groups: control, model and experimental groups. Control group (8 hamsters) were sacrificed at week 0 and week 12 for control. Model group (123 hamsters) were pasted in bilateral cheek pouches with 0.5% DMBA, 3 times a week for establishment of experimental leukoplasia, and sacrificed at week 2 to week 9 (12-22 hamsters were sacrificed a week). Experimental group (153 hamsters) were divided into three subgroups. Subgroup A underwent simultaneous DMBA pasting and oral taking of GP, and were sacrificed at week 6 and week 9. Subgroup B underwent oral taking of GP for 12 weeks after completion of DMBA pasting. Subgroup C underwent DMBA pasting after completion of oral taking of GP for 12 weeks. RESULTS: The earliest epithelial dysplasia and carcinoma in situ occurred at week 3 and week 6 after DMBA pasting. There were significant differences between subgroup B and model group for 3 weeks' administration of DMBA (P < 0.05), and between subgroup C and model group (P < 0.01), while there was no difference between subgroup B and model group for 6 week's administration of DMBA (P > 0.05). CONCLUSIONS: GP could inhibit and reverse the carcinomatous conversions of leukoplasia of golden hamster cheek pouches, indicating its positive anticarcinogenic effect.  相似文献
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Zhou Y  Li Z  An W  Qi Y  Zhang K  Lu W  Hu Y 《中华医学杂志(英文版)》1999,112(3):214-216
ObjectiveToevaluatethecornealsurfacechangesandvisualqualityafterexcimerphotorefractivekeratectomy(PRK)formyopia.MethodsCornea...  相似文献
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Sheng C  Zhang W  Zhang M  Song Y  Ji H  Zhu J  Yao J  Yu J  Yang S  Zhou Y  Lu J 《第二军医大学学报》2005,26(2):173-173
The crystal structure of 14alpha-sterol demethylase from Mycobacterium tuberculosis (MT_14DM) provides a good template for modeling the three dimensional structure of lanosterol 14alpha-demethylase, which is the target of azole antifungal agents. Homologous 3D models of lanosterol 14alpha-demethylase from Candida albicans (CA_14DM) and Aspergillus fumigatus (AF_14DM) were built on the basis of the crystal coordinates of MT_14DM in complex with 4-phenylimidazole and fluconazole. The reliability of the two models was assessed by Ramachandran plots, Profile-3D analysis, and by analyzing the consistency of the two models with the experimental data on the P450(14DM). The overall structures of the resulting CA_14DM model and AF_14DM model are similar to those of the template structures. The two models remain the core structure characteristic for cytochrome P450s and most of the insertions and deletions expose the molecular surface. The structurally and functionally important residues such as the heme binding residues, the residues lining the substrate access channel, and residues in active site were identified from the model. To explore the binding mode of the substrate with the two models, 24(28)-methylene-24,25-dihydrolanosterol was docked into the active site of the two models and hydrophobic interaction and hydrogen-bonding were found to play an important role in substrate recognition and orientation. These results provided a basis for experiments to probe structure-function relationships in the P450(14DM). Although CA_14DM and AF_14DM shared similar core structural character, the active site of the two models were quite different, thus allowing the rational design of specific inhibitors to the target enzyme and the discovery of novel antifungal agents with broad spectrum.  相似文献
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周应媛  张继明 《重庆医学》2015,(14):1876-1878
目的:探讨磁共振弥散加权成像(DWI)评价慢性乙型肝炎肝纤维化程度和肝炎活动度的价值。方法设置不同的弥散敏感系数b值对102例慢性乙型肝炎患者(肝炎组)和26例健康志愿者(对照组)进行磁共振DWI检查,测定并比较两组肝脏感兴趣区的表观弥散系数(ADC)值。肝炎组进一步分为纤维化组(n=74)和无纤维化组(n=28)。结果设置b值为100和200 s/mm2时,两组ADC值比较差异无统计学意义(P>0.05);b值为400、600和800 s/mm2时,肝炎组ADC值低于对照组,肝纤维化组ADC值低于无纤维化组,差异有统计学意义(P<0.05);b值为600及800 s/mm2时,肝纤维化组S3及S4期ADC值低于S0及S1期,差异有统计学意义(P<0.05);b值为100、200和400 s/mm2时,不同肝纤维化程度分期 ADC值间的差异无统计学意义(P>0.05);b值为800 s/mm2时,不同炎症活动度组G1与G4级的ADC值的差异有统计学意义(P<0.01),其余组间差异无统计学意义(P>0.05)。结论磁共振DWI技术在评价不同分期慢性乙型肝炎肝纤维化程度和活动度方面具有较好的应用价值,设置b值为800 s/mm2时,效果最佳。  相似文献
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半月板损伤的治疗从切除、修复到移植不断发展,但各种治疗方法仍有不足,故研究重点转向半月板重建与替代。组织工程化半月板经过多年发展仍有待解决的疑问,异体半月板移植在降低半月板损伤后骨关节炎发生率等方面取得良好的效果。  相似文献
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